4.7 Article

MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

MPEP Attenuates Intrahepatic Fat Accumulation in Obese Mice

Andrea Ferrigno et al.

Summary: In this study, the effects of mGluR5 blockade were evaluated in a mouse model of steatosis. It was found that MPEP can reduce fat accumulation and oxidative stress. This study provides the first in vivo evidence of the beneficial effects of MPEP in a murine model of steatosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Biochemistry & Molecular Biology

Role of hsa_circ_0000280 in regulating vascular smooth muscle cell function and attenuating neointimal hyperplasia via ELAVL1

Zunzhe Wang et al.

Summary: This study reveals that circRNA hsa_circ_0000280 regulates cell proliferation and neointimal hyperplasia by interacting with ELAVL1 and stabilizing CDKN1A mRNA, providing a potential diagnostic or therapeutic strategy for coronary heart disease.

CELLULAR AND MOLECULAR LIFE SCIENCES (2023)

Review Medicine, General & Internal

Inflammatory and fibrotic mechanisms in NAFLD-Implications for new treatment strategies

Youngmin A. Lee et al.

Summary: Non-alcoholic fatty liver disease consists of simple steatosis or a more advanced stage called non-alcoholic steatohepatitis (NASH). NASH is a multifactorial disease and currently there are no approved therapies, but clarification of underlying mechanisms may lead to the development of novel treatment strategies.

JOURNAL OF INTERNAL MEDICINE (2022)

Article Biochemistry & Molecular Biology

Detailed Molecular Mechanisms Involved in Drug-Induced Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: An Update

Laura Giuseppina Di Pasqua et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are global public health challenges. Drug-induced hepatic steatosis (DIHS) is a major cause of NAFLD/NASH, primarily through interfering with mitochondrial activity and inhibiting fatty acid oxidation.

BIOMEDICINES (2022)

Review Pharmacology & Pharmacy

The RNA-binding protein HuR in human cancer: A friend or foe

Xiaoqing Wu et al.

Summary: RNA-binding proteins (RBPs) are crucial transcription factors that interact with specific cis elements in mRNA to regulate stability and translation. HuR, an overexpressed RBP in various human cancers, has been identified as a prognostic factor for poor clinical outcomes. HuR promotes tumorigenesis by interacting with oncogenic mRNAs involved in different cancer hallmarks and therapy resistance. Reducing HuR levels in cancer cells leads to tumor regression in mouse xenograft models. This review summarizes the roles of HuR in cancer and other diseases, the therapeutic potential of HuR inhibition, and the current status of drug discovery targeting HuR.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Article Gastroenterology & Hepatology

The RNA binding protein human antigen R is a gatekeeper of liver homeostasis

Pallavi Subramanian et al.

Summary: The study found that hepatocyte-specific deficiency of HuR led to increased susceptibility to hepatic steatosis and fibrosis, as well as exacerbated inflammation, fibrosis, and HCC development on an NAFLD-inducing diet. The findings suggest that HuR plays a crucial role in maintaining liver homeostasis and preventing NAFLD-related fibrosis and HCC, indicating its potential therapeutic implications.

HEPATOLOGY (2022)

Article Geriatrics & Gerontology

PKCε Activation Restores Loss of PKCε, Manganese Superoxide Dismutase, Vascular Endothelial Growth Factor, and Microvessels in Aged and Alzheimer's Disease Hippocampus

Guetchyn Millien et al.

Summary: Activation of PKC epsilon can rescue a decrease in PKC epsilon, MnSOD, and VEGF via posttranscription regulation and alleviate oxidative stress, thereby preventing microvascular loss during aging and AD.

FRONTIERS IN AGING NEUROSCIENCE (2022)

Article Biochemistry & Molecular Biology

MCD Diet Rat Model Induces Alterations in Zinc and Iron during NAFLD Progression from Steatosis to Steatohepatitis

Giuseppina Palladini et al.

Summary: This study evaluated the effects of a methionine-choline-deficient diet on zinc and iron levels in the serum and liver, as well as their relationships with matrix metalloproteinases and their modulators, and hepatic fatty acids. The findings showed that the diet led to a decrease in serum and hepatic zinc levels, an increase in serum and hepatic iron levels, and alterations in hepatic matrix metalloproteinases and fatty acids.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Clinical Neurology

Evidence for novel cell defense mechanisms sustained by dimethyl fumarate in multiple sclerosis patients: the HuR/SOD2 cascade

Giulia Mallucci et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

Article Biochemistry & Molecular Biology

HuR-dependent SOD2 protein synthesis is an early adaptation to anchorage-independence

Yeon Soo Kim et al.

Summary: During metastasis, cancer cells need to adapt to loss of anchorage and resistance to anoikis. One important adaptation is the increase in antioxidant capacity and restoration of cellular redox balance. In ovarian cancer cells, an early response to detachment, a critical step in metastasis associated with increased oxidative stress, is the increase in mitochondrial superoxide dismutase SOD2 protein expression. This is achieved through the translational regulatory mechanism involving the cytosolic accumulation of the RNA binding protein HuR/ELAVL1 and the activation of mitogen-activated kinase p38.

REDOX BIOLOGY (2022)

Article Biochemistry & Molecular Biology

RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression

Yanyan Wang et al.

Summary: This study investigated the role of hepatocyte-specific HuR in regulating hepatic lipid metabolism and found that HuR deficiency leads to increased hepatic lipid accumulation, inflammation, disrupted bile acid homeostasis, and enhanced liver fibrosis. Additionally, HuR was identified as a repressor of H19 expression, and the downregulation of H19 alleviated NAFLD in mice with HuR deficiency.

CELL AND BIOSCIENCE (2022)

Article Biochemistry & Molecular Biology

High fat high fructose diet induces mild oxidative stress and reorganizes intermediary metabolism in male mouse liver: Alpha-ketoglutarate effects

Maria M. Bayliak et al.

Summary: This study investigated the effects of a high fat high fructose diet (HFFD) on mouse liver and found that it activated fructolysis and glycolysis, induced inflammation and oxidative stress. Additionally, supplementation with alpha-ketoglutarate (AKG) had weak modulating effects on HFFD-induced oxidative stress and changes in energetics in mouse liver.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2022)

Article Medicine, General & Internal

Genetic variations of three important antioxidative enzymes SOD2, CAT, and GPX1 in nonalcoholic steatohepatitis

Yi-Shin Huang et al.

Summary: The study found that mutations in the SOD2 and CAT genes may increase the risk of developing NASH, which could help identify high-risk NASH patients and provide a potential new avenue for the treatment of NASH.

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION (2021)

Review Biochemistry & Molecular Biology

Targeting the RNA-Binding Protein HuR as Potential Thera-Peutic Approach for Neurological Disorders: Focus on Amyo-Trophic Lateral Sclerosis (ALS), Spinal Muscle Atrophy (SMA) and Multiple Sclerosis

Vittoria Borgonetti et al.

Summary: RNA-binding proteins play a crucial role in regulating RNA functions and cell fate, with ELAV/Hu proteins being key players in the fate of newly transcribed mRNA. HuR, a member of the ELAV/Hu protein family, is important in the development of neurodegenerative disorders, particularly in demyelinating diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver disease by targeting PTEN

Mi Tian et al.

Summary: HuR levels in the liver affect lipid and glucose metabolism, as shown in mouse experiments demonstrating its role in hepatic steatosis and glucose tolerance, targeting PTEN for regulation.

CELL DEATH & DISEASE (2021)

Article Nutrition & Dietetics

High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease

Heather C. Spooner et al.

Summary: The study found that high-fructose, high-fat diets may lead to an increase in total triacylglycerol content in muscle tissue, but a decrease in intramyocellular lipid content and the number of type I (slow oxidative) muscle fibers. Additionally, high-fructose, high-fat diets also induced autophagy and inflammation responses.

NUTRIENTS (2021)

Review Medicine, General & Internal

Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini Review

Anna Pia Delli Bovi et al.

Summary: This article discusses the interplay between oxidative stress and other pathogenic factors in non-alcoholic fatty liver disease (NAFLD), emphasizing the importance of reactive oxygen species (ROS) in NAFLD progression. It also points out the effectiveness of healthy diet and physical activity in NAFLD treatment, but lack of compliance, and the potential of precision medicine in selecting the best treatment for specific patients.

FRONTIERS IN MEDICINE (2021)

Article Integrative & Complementary Medicine

Hepatoprotective effect of Qushihuayu formula on non-alcoholic steatohepatitis induced by MCD diet in rat

Qingping Lan et al.

Summary: In this study, the hepatoprotective effect of QSHY formula against NASH was investigated in a rat model. The results showed that QSHY formula depressed MAPK pathways phosphorylation, reinforced PPAR-gamma and p-p65 translocating into nucleus, and enhanced HSCs reprogramming, suggesting its potential in treating steatosis and fibrosis.

CHINESE MEDICINE (2021)

Review Microbiology

Gut Microbiota and NAFLD: Pathogenetic Mechanisms, Microbiota Signatures, and Therapeutic Interventions

Tomas Hrncir et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, highly associated with metabolic syndrome. Dysbiosis of gut microbiota and disruption of intestinal permeability may play a role in its development. Therapeutic strategies include fecal microbiota transplantation, probiotics, prebiotics, and other approaches.

MICROORGANISMS (2021)

Review Endocrinology & Metabolism

Endoplasmic Reticulum Stress and Autophagy in the Pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD): Current Evidence and Perspectives

Christina-Maria Flessa et al.

Summary: The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) are closely related to endoplasmic reticulum (ER) stress and autophagy processes, which have emerged as promising targets for therapeutic interventions. Current research focuses on finding natural/chemical compounds and drugs that can modulate these pathways to attenuate NAFLD progression. Further investigation into the interaction between ER stress, autophagy, inflammatory responses, and apoptotic mechanisms may lead to the development of more effective therapeutic options for NAFLD.

CURRENT OBESITY REPORTS (2021)

Article Biochemistry & Molecular Biology

Long-term cold storage preservation does not affect fatty livers from rats fed with a methionine and choline deficient diet

Laura Giuseppina Di Pasqua et al.

Summary: This study investigated the effects of different lipidomic profiles on the outcome of fatty livers during long-term cold storage preservation. The findings suggest that the quality of lipid constituents may influence liver injury during cold storage, with a particular focus on the role of saturated fatty acids in reducing deleterious effects under cold ischemia.

LIPIDS IN HEALTH AND DISEASE (2021)

Review Biochemistry & Molecular Biology

The Role of Oxidative Stress in NAFLD-NASH-HCC Transition-Focus on NADPH Oxidases

Daniela Gabbia et al.

Summary: Oxidative stress plays a significant role in the progression of non-alcoholic fatty liver disease (NAFLD) to more severe complications including non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). NADPH oxidases (NOXs) are enzymes that produce reactive oxygen species (ROS) and their abundance in liver cells is closely related to inflammation and immune responses. The differential effects of NOX isoforms, such as NOX1, NOX2, and NOX4, on liver disease progression and HCC prognosis require further investigation.

BIOMEDICINES (2021)

Article Respiratory System

HuR drives lung fibroblast differentiation but not metabolic reprogramming in response to TGF-β and hypoxia

Joshua Trivlidis et al.

Summary: Pulmonary fibrosis is believed to be driven by alveolar epithelial injury, leading to fibroblast differentiation and extracellular matrix deposition. Transforming growth factor beta-1 (TGF-beta 1) and the RNA binding protein HuR play key roles in this process. Hypoxia, in conjunction with TGF-beta 1, affects gene and protein expression in HLFs, with HuR controlling myofibroblast differentiation but not glycolysis.

RESPIRATORY RESEARCH (2021)

Review Gastroenterology & Hepatology

Mitochondrial dysfunction in nonalcoholic fatty liver disease and alcohol related liver disease

Pankaj Prasun et al.

Summary: Fatty liver disease encompasses a range of liver diseases, with NAFLD being a global epidemic linked to modern dietary habits and lifestyle. ALD and NAFLD are the two main etiologies, with common themes in progression despite differing triggers for steatosis onset. Understanding the role of mitochondrial dysfunction in the pathogenesis of these diseases is crucial for more effective interventions.

TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

Mechanisms of Fibrosis Development in NASH

Robert F. Schwabe et al.

GASTROENTEROLOGY (2020)

Article Biotechnology & Applied Microbiology

Heme Oxygenase-1 Suppresses Wnt Signaling Pathway in Nonalcoholic Steatohepatitis-Related Liver Fibrosis

Jinghua Du et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Article Clinical Neurology

Unraveling a new player in multiple sclerosis pathogenesis: The RNA-binding protein HuR

Cristiana Pistono et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Article Multidisciplinary Sciences

Hepatic HuR modulates lipid homeostasis in response to high-fat diet

Zhuojun Zhang et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: Current Issues and Future Perspectives in Preclinical and Clinical Research

Clarissa Berardo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Pharmacology & Pharmacy

Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments

Cheng Peng et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Adipose HuR protects against diet-induced obesity and insulin resistance

Jingyuan Li et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Liver Graft Susceptibility during Static Cold Storage and Dynamic Machine Perfusion: DCD versus Fatty Livers

Andrea Ferrigno et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Selective Blockade of the Metabotropic Glutamate Receptor mGluR5 Protects Mouse Livers in In Vitro and Ex Vivo Models of Ischemia Reperfusion Injury

Andrea Ferrigno et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Gastroenterology & Hepatology

Genetics and epigenetics of NAFLD and NASH: Clinical impact

Mohammed Eslam et al.

JOURNAL OF HEPATOLOGY (2018)

Article Gastroenterology & Hepatology

Malondialdehyde Epitopes Are Sterile Mediators of Hepatic Inflammation in Hypercholesterolemic Mice

Clara Jana-Lui Busch et al.

HEPATOLOGY (2017)

Article Gastroenterology & Hepatology

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Auvro R. Mridha et al.

JOURNAL OF HEPATOLOGY (2017)

Article Biochemistry & Molecular Biology

NAD(P)H and Flavin Autofluorescence Correlation with ATP in Rat Livers with Different Metabolic Steady-State Conditions

Anna C. Croce et al.

PHOTOCHEMISTRY AND PHOTOBIOLOGY (2017)

Article Biochemistry & Molecular Biology

Autofluorescence discrimination of metabolic fingerprint in nutritional and genetic fatty liver models

Anna C. Croce et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2016)

Article Endocrinology & Metabolism

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Elena Buzzetti et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

Review Biotechnology & Applied Microbiology

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

Giovanni Musso et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

Article Neurosciences

Involvement of ELAV RNA-binding proteins in the post-transcriptional regulation of HO-1

Marialaura Amadio et al.

Frontiers in Cellular Neuroscience (2015)

Article Biochemistry & Molecular Biology

Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

Svetlana Lebedeva et al.

MOLECULAR CELL (2011)

Review Biochemistry & Molecular Biology

Redox Control of Liver Function in Health and Disease

Montserrat Mari et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Review Biochemistry & Molecular Biology

Phosphatidylcholine and choline homeostasis

Zhaoyu Li et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Substance Abuse

Mutation of mitochondrial DNA in livers from patients with alcoholic hepatitis and nonalcoholic steatohepatitis

Hiromu Kawahara et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2007)

Article Gastroenterology & Hepatology

Hepatic cytochrome p450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis

N Chalasani et al.

HEPATOLOGY (2003)