Role of Plant-Derived Compounds in the Molecular Pathways Related to Inflammation

Article Biochemistry & Molecular Biology

Cyanidin-3-O-glucoside protects intestinal epithelial cells from palmitate-induced lipotoxicity

Romina Bashllari et al.

Summary: This study investigated the intracellular mechanisms involved in FFAs modulation of intestinal epithelial lipotoxicity and the protective effects of cyanidin-3-O-glucoside (C3G) in Caco-2 cells using a novel experimental model.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2023)

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Article Multidisciplinary Sciences

Network pharmacology and experimental validation to identify the potential mechanism of Hedyotis diffusa Willd against rheumatoid arthritis

Hui Deng et al.

Summary: In this study, a network pharmacology approach, microarray data analysis, and molecular docking were used to predict the key active ingredients and mechanisms of Hedyotis diffusa Willd (HDW) against rheumatoid arthritis (RA). The results showed that HDW contains 11 active ingredients and 180 potential anti-RA targets. The study also identified stigmasterol, beta-sitosterol, quercetin, kaempferol, and 2-methoxy-3-methyl-9,10-anthraquinone as key components for RA treatment. Pathway analysis revealed that the potential targets were mainly related to inflammatory pathways such as AGE-RAGE, TNF, IL17, and PI3K-Akt signaling pathways. Furthermore, RELA, TNF, IL6, TP53, MAPK1, AKT1, IL10, and ESR1 were identified as hub targets for HDW in treating RA. Molecular docking confirmed the binding of the key components and the hub targets. In vitro experiments demonstrated that HDW inhibits cell proliferation in MH7A cells and affects hub targets through the PI3K/AKT signaling pathway. This study provides evidence for the clinical effect of HDW on RA and lays a foundation for further investigation into its active ingredients and mechanisms against RA.

SCIENTIFIC REPORTS (2023)

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Article Orthopedics

Deciphering the protective effect of Buzhong Yiqi Decoction on osteoporotic fracture through network pharmacology and experimental validation

Zhen Hua et al.

Summary: Using network pharmacology and animal experiments, it was found that the Chinese medicine formula Buzhong Yiqi Decoction (BZYQD) can improve the characteristics of osteoporotic fracture (OPF), reduce inflammation and oxidative stress, and promote fracture repair by suppressing NF-kappa B and activating Nrf2/MAPK signaling pathways.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2023)

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Article Integrative & Complementary Medicine

Exploring the active components and potential mechanisms of Rosa roxburghii Tratt in treating type 2 diabetes mellitus based on UPLC-Q-exactive Orbitrap/MS and network pharmacology

Chenxiao Shen et al.

Summary: This study explored the active components and potential mechanisms of Rosa roxburghii Tratt fruit in the treatment of Type 2 diabetes mellitus (T2DM) using UPLC-Q-Exactive Orbitrap/MS and network pharmacology approaches. The study identified 20 bioactive ingredients in the fruit, including alphitolic acid, quercetin, and ellagic acid, as well as 13 core targets such as AKT1, TNF, SRC, and VEGFA. Rosa roxburghii Tratt fruit may play a therapeutic role in T2DM by regulating signaling pathways such as PI3K/AKT, RAS, and AGE-RAGE.

CHINESE MEDICINE (2023)

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Review Food Science & Technology

Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review

Felipe Tecchio Borsoi et al.

Summary: Chronic Non-Communicable Diseases (NCDs) are a global health problem characterized by multiple factors, lifelong development, and a significant increase in mortality due to environmental factors and lifestyle. The overproduction of reactive species (ROS/RNS) is directly associated with the pathogenesis and worsening of NCDs. Dietary polyphenols are widely recognized for their ability to reduce oxidative stress and inflammation. They have also been found to modulate gene expression and epigenetic alterations, suggesting a crucial role in the prevention and development of NCDs.

FOOD CHEMISTRY: MOLECULAR SCIENCES (2023)

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Article Integrative & Complementary Medicine

Exploring the mechanism of the Fructus Mume and Rhizoma Coptidis herb pair intervention in Ulcerative Colitis from the perspective of inflammation and immunity based on systemic pharmacology

Yatian Yang et al.

Summary: This study evaluated the therapeutic effect of Fructus Mume (FM) and Rhizoma Coptidis (RC) on ulcerative colitis (UC) through network pharmacology-based analyses, molecular docking, and experimental validation. The results showed that FM and RC could alleviate UC by reducing inflammatory indicators and regulating immune response. This study provides a better understanding of the treatment of UC with FM and RC.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2023)

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Article Biochemistry & Molecular Biology

Formononetin inhibits inflammation and promotes gastric mucosal angiogenesis in gastric ulcer rats through regulating NF-κB signaling pathway

Lanjie Yi et al.

Summary: The study found that formononetin has a good therapeutic effect on gastric ulcers in rats, it can improve the condition by inhibiting inflammation and promoting gastric mucosal angiogenesis.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2022)

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Article Chemistry, Multidisciplinary

Verbascoside inhibits paraquate-induced pulmonary toxicity via modulating oxidative stress, inflammation, apoptosis and DNA damage in A549 cell

Nastaran Khorashadizadeh et al.

Summary: Paraquat (PQ) exposure can result in cell death, oxidative stress and inflammatory responses, while verbascoside (VB) can protect A549 cells from PQ-induced injury by modulating antioxidant enzyme activity and anti-inflammatory responses.

DRUG AND CHEMICAL TOXICOLOGY (2022)

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Article Toxicology

Cyanidin-3-glucoside protects against high glucose-induced injury in human nucleus pulposus cells by regulating the Nrf2/HO-1 signaling

Xiaoliang Bai et al.

Summary: This study found that C3G has a protective effect on high glucose-induced damage in human nucleus pulposus cells (HNPCs), which can reduce ROS production through the induction of the Nrf2/HO-1 signaling pathway.

JOURNAL OF APPLIED TOXICOLOGY (2022)

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Article Pharmacology & Pharmacy

Punicalagin Alleviates Psoriasis by Inhibiting NF-κB-Mediated IL-1β Transcription and Caspase-1-Regulated IL-1β Secretion

Lipeng Tang et al.

Summary: Punicalagin (PUN) shows therapeutic potential for psoriasis by inhibiting inflammatory response and cell signaling pathways.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy

Xiaoli Pan et al.

Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Chemistry, Medicinal

D(-)-salicin inhibits RANKL-induced osteoclast differentiation and function in vitro

Yu Xiao et al.

Summary: In this study, it was found that D-(-)-salicin (DSA) can inhibit the formation and function of osteoclasts in osteoporosis by suppressing ROS signaling, MAPK, and NF-kappa B cascades.

FITOTERAPIA (2022)

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Article Environmental Sciences

The ameliorative effect of kaempferol against CdCl2-mediated renal damage entails activation of Nrf2 and inhibition of NF-kB

Ali S. Alshehri et al.

Summary: This study demonstrates that kaempferol has a nephroprotective effect against cadmium-induced nephropathy by reducing kidney damage, improving kidney function, and attenuating oxidative stress and inflammation. It achieves these effects by suppressing NF-kappa B p65 and activating Nrf2.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Article Pharmacology & Pharmacy

Urolithin A attenuates RANKL-induced osteoclastogenesis by co-regulating the p38 MAPK and Nrf2 signaling pathway

Wei Wei et al.

Summary: Urolithin A can attenuate RANKL-induced osteoclastogenesis by suppressing inflammation and activating the Nrf2 signaling pathway, thereby alleviating bone loss.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Epigallocatechin Gallate Protects against Hypoxia-Induced Inflammation in Microglia via NF-κB Suppression and Nrf-2/HO-1 Activation

So-Ra Kim et al.

Summary: EGCG protects microglia from hypoxia-induced inflammation and oxidative stress through inhibition of the NF-κB pathway and activation of the Nrf-2/HO-1 pathway.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Urolithin A Inactivation of TLR3/TRIF Signaling to Block the NF-κB/STAT1 Axis Reduces Inflammation and Enhances Antioxidant Defense in Poly(I:C)-Induced RAW264.7 Cells

Wen-Chung Huang et al.

Summary: Urolithin A, an active compound found in gut microbiota-derived metabolites of polyphenol ellagic acid, has been shown to have anti-aging, antioxidative, and anti-inflammatory effects. This study investigated the effects of urolithin A on poly(I:C)-induced inflammation in immune cells. The results demonstrated that urolithin A attenuated the inflammatory response and regulated various signaling pathways involved in inflammation and antioxidation. These findings suggest that urolithin A may have antiviral effects and could potentially be used as a treatment for viral-infection-related diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Plant Sciences

Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway

Ying Zhang et al.

Summary: The study evaluates the renal protective effect of esculetin against the progression of lupus nephritis and finds that esculetin can significantly improve renal function and pathology. It exhibits antioxidant and anti-inflammatory properties and acts on LN through multiple pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Biology

Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-kappa B signaling pathway

Gaoran Ge et al.

Summary: The study revealed that punicalagin could ameliorate pathological inflammation in rheumatoid arthritis by modulating macrophage polarization and inhibiting pyroptosis, suggesting its great potential as a therapeutic treatment for human RA.

SCIENCE CHINA-LIFE SCIENCES (2022)

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Review Cell Biology

A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver Diseases

Devaraj Ezhilarasan et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in the liver, often associated with metabolic syndromes. Oxidative stress plays a significant role in the progression of NAFLD, and various antioxidants have been tested in clinical trials. However, none of these antioxidants have been proven as definitive therapeutic agents for NAFLD patients, and further research with larger populations and multiple endpoints is needed.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Nutrition & Dietetics

The Neuroprotection of Verbascoside in Alzheimer's Disease Mediated through Mitigation of Neuroinflammation via Blocking NF-κB-p65 Signaling

Shanshan Chen et al.

Summary: The neuroprotective mechanism of Verbascoside (VB) was explored in this study. Proteomic analysis and immunological methods revealed that VB exerts its neuroprotective effect by inhibiting neuroinflammation and modulating the NF-kappa B-p65 pathway. These findings suggest that VB could be a potential candidate drug for the prevention and treatment of Alzheimer's disease (AD).

NUTRIENTS (2022)

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Article Nutrition & Dietetics

Potentially Bio-Accessible Metabolites from an Extract of Cornus mas Fruit after Gastrointestinal Digestion In Vitro and Gut Microbiota Ex Vivo Treatment

Agata Oledzka et al.

Summary: The study aimed to investigate the targeting effect of Cornus mas fruit extract on pancreatic lipase and alpha-amylase, as well as the changes in metabolites and kinetics during gastrointestinal digestion. The results showed that the extract inhibited the activity of pancreatic lipase and alpha-amylase, and compounds such as loganic acid, kaempferol hexoside, and phenolic acids were found to be potentially bio-accessible.

NUTRIENTS (2022)

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Review Biochemistry & Molecular Biology

Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases

Jun Liu et al.

Summary: Dysregulation of auto-reactive T cells and autoantibody-producing B cells, as well as excessive inflammation, contribute to the development of autoimmune diseases. Pattern recognition receptors (PRRs) play a significant role in autoimmune diseases and targeting these receptors may be a viable therapeutic strategy. This review summarizes the advancements in PRRs signaling pathways, their association with autoimmune diseases, and the application of inhibitors targeting PRRs.

CELL AND BIOSCIENCE (2022)

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Article Pharmacology & Pharmacy

Isorhamnetin Alleviates Airway Inflammation by Regulating the Nrf2/Keap1 Pathway in a Mouse Model of COPD

Yifan Xu et al.

Summary: This study found that isorhamnetin can significantly alleviate the inflammatory response in COPD mice induced by cigarette smoke, mainly by affecting the Nrf2/Keap1 pathway. It improves lung function without discernible side effects, making it a potential drug candidate for COPD.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Echinacoside Protects Dopaminergic Neurons Through Regulating IL-6/JAK2/STAT3 Pathway in Parkinson's Disease Model

Xueping Yang et al.

Summary: This study found that Echinacoside (ECH) exerts neurotrophic and anti-inflammatory effects by regulating the IL-6/JAK2/STAT3 pathway and the phosphorylation of STAT3, promoting the mutually beneficial influence of the two effects to maximize its neuroprotective function.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Immunology

Echinacoside Induces Mitochondria-Mediated Pyroptosis through Raf/MEK/ERK Signaling in Non-Small Cell Lung Cancer Cells

Ye Shi et al.

Summary: The study found that Ech inhibited the proliferation of NSCLC cells and activated inflammasome, leading to pyroptosis of the cells. Additionally, Ech suppressed the growth of tumors by inhibiting the Raf/MEK/ERK signaling pathway.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Silibinin Protects against H2O2-Induced Oxidative Damage in SH-SY5Y Cells by Improving Mitochondrial Function

Fangfang Tie et al.

Summary: The present study demonstrated that silibinin attenuated H2O2-induced oxidative stress by regulating Nrf2 signaling and improving mitochondrial function in human neuroblastoma cells. This suggests that silibinin could be a potential candidate for preventing neurodegenerative diseases.

ANTIOXIDANTS (2022)

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Review Biochemistry & Molecular Biology

Role of Phenylpropanoids and Flavonoids in Plant Resistance to Pests and Diseases

Marie-Louisa Ramaroson et al.

Summary: Phenylpropanoids and flavonoids are specialized metabolites involved in plant defense, and their protective action may arise from interference with important cellular machineries and structures. Although there has been progress in understanding their biosynthesis and regulation, there are still many gaps in knowledge that need to be filled.

MOLECULES (2022)

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Article Cell Biology

Urolithin B suppressed osteoclast activation and reduced bone loss of osteoporosis via inhibiting ERK/NF-κB pathway

Yajun Li et al.

Summary: Urolithin B attenuated bone loss in OVX mice by inhibiting the formation and activation of osteoclasts via down-regulation of the ERK/NF-kappa B signaling pathway.

CELL PROLIFERATION (2022)

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Article Immunology

NLRP3 inflammasome: A potential therapeutic target to minimize renal ischemia/reperfusion injury during transplantation

Xiaochen Su et al.

TRANSPLANT IMMUNOLOGY (2022)

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Article Immunology

Echinacoside alleviates osteoarthritis in rats by activating the Nrf2-HO-1 signaling pathway

Zhijun Tan et al.

Summary: In this study, the effect of Ech on osteoarthritis (OA) was investigated. Results showed that Ech enhanced the viability of rat chondrocytes, repressed inflammatory response and extracellular matrix degradation, and alleviated oxidative stress. Mechanically, Ech achieved these effects by activating the Nrf2/HO-1 signaling pathway. Additionally, Ech showed protective effects in vivo in a rat model of OA.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2022)

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Article Cell Biology

Urolithin B suppresses osteoclastogenesis via inhibiting RANKL-induced signalling pathways and attenuating ROS activities

Zechao Qu et al.

Summary: Urolithin B (UB) inhibits RANKL-induced osteoclast differentiation by regulating ROS activity and multiple signaling pathways, thus suppressing osteoporosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Chemistry, Medicinal

Echinacoside Ameliorates Cyclophosphamide-Induced Bladder Damage in Mice

Yunpeng Shao et al.

Summary: Interstitial cystitis (IC) is characterized by apoptosis and chronic inflammation in bladder tissue. This study found that echinacoside (ECH) can improve bladder function, reduce inflammatory damage, and decrease apoptosis in IC models. The protective effect of ECH against IC in the bladder may be mediated through modulation of the PPAR gamma/NF-kappa B pathway.

JOURNAL OF MEDICINAL FOOD (2022)

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Article Oncology

Hyperoside ameliorates TNF-a-induced inflammation, ECM degradation and ER stress-mediated apoptosis via the SIRT1/NF-?B and Nrf2/ARE signaling pathways in vitro

Tian Xie et al.

Summary: This study found that hyperoside can alleviate TNF-alpha-induced apoptosis in intervertebral disc cells, and its mechanism involves the regulation of the SIRT1/NF-kappa B and Nrf2/antioxidant responsive element signaling pathways.

MOLECULAR MEDICINE REPORTS (2022)

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Article Neurosciences

Echinacoside Improves Cognitive Impairment by Inhibiting Aβ Deposition Through the PI3K/AKT/Nrf2/PPARγ Signaling Pathways in APP/PS1 Mice

Hui Qiu et al.

Summary: This study found that ECH can improve cognitive function in AD mice and exert anti-inflammatory and antioxidant effects through multiple signaling pathways.

MOLECULAR NEUROBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide

Marcin Feldo et al.

Summary: This study investigated the effects of diosmin and diosmetin on modulating proinflammatory factor levels in human skin fibroblasts. The results showed that both flavonoids reduced levels of IL-6 and Il-1 beta as well as COX-2 and PGE2, with no impact on IL-10. The compounds were more effective when added prior to LPS stimulation, and diosmetin had a stronger modulating effect.

MOLECULES (2022)

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Article Cell Biology

Vitexin Mitigates Staphylococcus aureus-Induced Mastitis via Regulation of ROS/ER Stress/NF-κB/MAPK Pathway

Yu Chen et al.

Summary: Vitexin has antioxidant and anti-inflammatory functions that can improve Staphylococcus aureus-induced mastitis. By activating PPAR gamma, vitexin blocks the production of ROS, increases the activity of antioxidant enzymes, reduces the production of inflammatory cytokines, and inhibits apoptosis and ER stress. Vitexin also inactivates MAPKs and NF-kappa B signaling pathway, reducing phosphorylation levels and inflammatory response.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Cell Biology

Silibinin Ameliorates Formaldehyde-Induced Cognitive Impairment by Inhibiting Oxidative Stress

Pengsheng Wei et al.

Summary: This study investigated the mechanism of silibinin in improving cognitive impairment and found that silibinin has antioxidative stress, anti-apoptotic, and cognitive-enhancing effects in formaldehyde-induced mice. Silibinin exerts antioxidative stress effects by promoting the nuclear transfer of NRF2 and increasing the expression of HO-1. In addition, silibinin reduces the content of DHE, decreases apoptosis in mature neuron cells, and increases the levels of formaldehyde degrading enzymes. Furthermore, silibinin inhibits GSK-3 beta expression, thereby reducing the phosphorylation of TAU proteins mediated by GSK3 beta.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Immunology

Ellagic acid protects type II collagen induced arthritis in rat via diminution of IKB phosphorylation and suppression IKB-NF-kB complex activation: in vivo and in silico study

Mahmood Ahmad Khan et al.

Summary: The objective of this study was to investigate the anti-inflammatory and anti-arthritic effects of ellagic acid (EA) in collagen-induced arthritis (CIA). The findings demonstrated that EA significantly reduced inflammation and oxidative stress, and inhibited the development of arthritis in rats. These results suggest that EA could serve as a potential new drug for the treatment of arthritis.

INFLAMMOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

(-)-Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-KB signaling

Guijuan Chen et al.

Summary: This study suggests that (-)-epicatechin gallate (ECG) can alleviate hypoxic hyperactivated microglia, reduce neuroinflammation and blood-brain barrier permeability, and prevent high-altitude cerebral edema (HACE) by inhibiting NF -KB signaling pathway.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2022)

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Article Pharmacology & Pharmacy

Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy

Hui Fan et al.

Summary: The study suggests that malvidin is a potential protective agent against LPS-induced acute liver injury (ALI) by up-regulating the Nrf2 signaling pathway, suppressing NLRP3 inflammasome, and inhibiting apoptosis and autophagy.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death

Alayn' Al-marddyah A. Al-khawalde et al.

Summary: This study investigated the effect of punicalagin on methotrexate-induced hepatotoxicity. The results showed that punicalagin can alleviate the damage caused by methotrexate, inhibit oxidative damage, inflammation, and apoptosis, and enhance antioxidant defenses. These findings suggest that punicalagin may have therapeutic potential for the prevention of methotrexate-induced hepatotoxicity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Plant Sciences

Aesculetin exhibited anti-inflammatory activities through inhibiting NF-?B and MAPKs pathway in vitro and in vivo

Shou-Kai Wang et al.

Summary: Aesculetin exhibits potent anti-inflammatory effect both in vitro and in vivo by inhibiting the production of inflammatory mediators and the activation of NF-Kappa B and MAPKs signaling pathways. In a DSS-induced colitis model, aesculetin can alleviate clinical symptoms and reduce the secretion of inflammatory mediators.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Hesperidin Protects SH-SY5Y Neuronal Cells against High Glucose-Induced Apoptosis via Regulation of MAPK Signaling

Chaemoon Lim et al.

Summary: This study found that hesperidin can inhibit high glucose-induced apoptosis and mitigate oxidative stress and endoplasmic reticulum stress. It also promotes cell survival through modulation of the mitogen-activated protein kinase signaling pathway.

ANTIOXIDANTS (2022)

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Article Chemistry, Medicinal

Taxifolin Prevents Cisplatin Nephrotoxicity by Modulating Nrf2/HO-1 Pathway and Mitigating Oxidative Stress and Inflammation in Mice

Abdulkareem A. Alanezi et al.

Summary: This study investigated the protective effect of taxifolin on cisplatin-induced acute kidney injury (AKI). The results showed that taxifolin could mitigate tissue injury, oxidative stress, inflammation, and cell death, and exert its protective effect by upregulating the Nrf2/HO-1 signaling pathway.

PHARMACEUTICALS (2022)

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Review Cardiac & Cardiovascular Systems

The role of CD36 in cardiovascular disease

Hongyang Shu et al.

Summary: CD36 is a multifunctional receptor widely expressed in various organs, and plays a crucial role in the uptake of fatty acids in myocardial tissue. Its regulation and post-translational modifications are closely associated with the progression of cardiovascular diseases, suggesting it as a potential therapeutic target.

CARDIOVASCULAR RESEARCH (2022)

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Article Surgery

Genistein improves mitochondrial function and inflammatory in rats with diabetic nephropathy via inhibiting MAPK/NF-κB pathway

Ying Li et al.

Summary: Genistein alleviated diabetic nephropathy by inhibiting the MAPK/NF-kappa B pathway, improving mitochondrial function, and anti-inflammatory effects.

ACTA CIRURGICA BRASILEIRA (2022)

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Article Anatomy & Morphology

Isorhamnetin attenuates TNF-α-induced inflammation, proliferation, and migration in human bronchial epithelial cells via MAPK and NF-κB pathways

Xiaojie Ren et al.

Summary: Isorhamnetin inhibits inflammation, proliferation, and migration of bronchial epithelial cells by regulating the MAPK and NF-kappa B signaling pathways, making it a potential drug candidate for asthma.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2021)

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Article Plant Sciences

Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study

Kai Sun et al.

Summary: The study demonstrated that Hyperoside (Hyp) can inhibit IL-1 beta-induced apoptosis and inflammatory responses in chondrocytes, while regulating the expression of key proteins, suggesting its potential for the treatment of osteoarthritis.

PHYTOMEDICINE (2021)

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Article Cell Biology

Resveratrol alleviates bleomycin-induced pulmonary fibrosis via suppressing HIF-1α and NF-κB expression

Zaiyan Wang et al.

Aging-US (2021)

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Review Pharmacology & Pharmacy

Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-kappa B to Halt Alzheimer's Disease

Md Sahab Uddin et al.

Summary: Alzheimer's disease is a chronic brain disorder with no exact remedies currently available. Neuroinflammation plays a crucial role in AD pathogenesis, with NF-kappa B showing promise as a candidate for inflammation-based therapy. Phytochemicals, particularly polyphenols, exhibit neuroprotective functions and may interfere with NF-kappa B signaling pathway to potentially combat AD.

CURRENT PHARMACEUTICAL DESIGN (2021)

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Article Pharmacology & Pharmacy

The inhibitory effect of (-)-Epicatechin gallate on the proliferation and migration of vascular smooth muscle cells weakens and stabilizes atherosclerosis

Weifeng Li et al.

Summary: The study found that ECG can inhibit VSMCs proliferation and migration, reduce cholesterol levels and oxidative stress by regulating inflammation, cell cycle, and gene expression pathways, suggesting potential clinical applications in preventing atherosclerosis.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Immunology

The impact of ellagic acid on some apoptotic gene expressions: a new perspective for the regulation of pancreatic Nrf-2/NF-κB and Akt/VEGF signaling in CCl4-induced pancreas damage in rats

Abdullah Aslan et al.

Summary: In this study, ellagic acid (EA) was found to have potential therapeutic effects on pancreatic injury in rats. EA showed increased Nrf-2 and caspase-3 protein expressions, catalase activities, and GSH levels, while reducing TNF-α, NF-κB, Bcl-2, VEGF, and Akt protein expressions and MDA levels in the EA + CCl4 group compared to the CCl4 group. These results suggest that EA may be effective in reducing pancreas tissue injury and could be used as a drug in the future.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2021)

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Article Biochemistry & Molecular Biology

Synergism and Subadditivity of Verbascoside-Lignans and -Iridoids Binary Mixtures Isolated from Castilleja tenuiflora Benth. on NF-κB/AP-1 Inhibition Activity

Luis David Arango-De la Pava et al.

Summary: Pharmacodynamic interactions between plant isolated compounds are crucial for understanding the mode of action of herbal extracts. In this study, eight compounds were isolated from Castilleja tenuiflora, with four new lignans showing potential inhibition of the NF-kappa B/AP-1 pathway. Verbascoside was identified as a key compound for creating synergistic mixtures with other lignans, offering promising applications for treating NF-kappa B/AP-1 related diseases and inflammation.

MOLECULES (2021)

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Article Plant Sciences

Suppression of up-regulated LXRα by silybin ameliorates experimental rheumatoid arthritis and abnormal lipid metabolism

Ying Xie et al.

Summary: The study demonstrates that silybin can ameliorate dyslipidemia and arthritis in AIA rats through modulating lipid metabolism and suppressing the up-regulated LXR alpha, highlighting the potential of LXR alpha inhibition as a therapeutic target for rheumatoid arthritis.

PHYTOMEDICINE (2021)

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Article Pharmacology & Pharmacy

Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells

Jinzhi Tong et al.

Summary: The study demonstrated that PGG inhibits the JAK2/STAT3 cascade by activating Nrf2/HO-1 signaling, which in turn suppresses ROS generation and inflammatory cytokines induced by AGE. Moreover, the involvement of Nrf2 in blocking the JAK2/STAT3 cascade by PGG was confirmed using the Nrf2 transcriptional inhibitor ML385.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)

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Article Medicine, Research & Experimental

Punicalagin prevents cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammatory response, and apoptosis in rats

Saleem H. Aladaileh et al.

Summary: This study demonstrated that punicalagin (PUN) can alleviate cisplatin-induced renal oxidative stress, inflammatory response, and cell death, enhance antioxidant defenses, and protect kidney function.

LIFE SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Polyphenols Targeting MAPK Mediated Oxidative Stress and Inflammation in Rheumatoid Arthritis

Tapan Behl et al.

Summary: Rheumatoid arthritis is a chronic autoimmune disorder that causes joint inflammation and limited physical function. Natural extracts with polyphenolic compounds show promise as adjuvant agents in managing RA due to their antioxidant and anti-inflammatory properties.

MOLECULES (2021)

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Article Biochemistry & Molecular Biology

Anti-Inflammatory Effects of Ellagic Acid on Keratinocytes via MAPK and STAT Pathways

Tae-Young Gil et al.

Summary: Atopic dermatitis is a chronic inflammatory skin disease with no fully effective therapeutic agents. Ellagic acid, a natural compound with anti-inflammatory properties, has shown potential as an alternative treatment for atopic dermatitis by regulating inflammatory signaling pathways and improving skin lesions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-κB activated pyroptosis pathways

Huaqiang Tao et al.

Summary: UA administration reduced systemic bone loss in ovariectomized animals by suppressing osteoclast formation through modulation of the inflammatory signal-dependent pyroptosis pathway, indicating its potential as a safe and promising therapeutic strategy for osteoclast-related bone diseases like OP.

PHARMACOLOGICAL RESEARCH (2021)

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Article Plant Sciences

Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation

Zi-Ling Zou et al.

Summary: The study demonstrates that avicularin protects against cartilage extracellular matrix degradation and inflammation by inhibiting the TRAF6/MAPK pathway and targeting TRAF6, making it a potential therapeutic agent for osteoarthritis.

PHYTOMEDICINE (2021)

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Article Medicine, Research & Experimental

Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats

Bolin Li et al.

Summary: The study showed that luteolin significantly reduced colonic damage and inflammation in UC rats, and altered the diversity and composition of gut microbiota. The findings suggest that gut microbiota could serve as promising biomarkers for understanding how luteolin improves UC.

LIFE SCIENCES (2021)

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Article Oncology

Cyanidin-3-O-β-glucoside protects against pulmonary artery hypertension induced by monocrotaline via the TGF-β1/p38 MAPK/CREB signaling pathway

Shao Ouyang et al.

Summary: The study indicated that Cy-3-g could effectively inhibit PAH in rats induced by MCT, as well as suppress inflammation, block oxidative stress, improve vascular endothelial injury, and reduce SMC proliferation. Cy-3-g also blocked the expression of TGF-beta 1/p38 MAPK/CREB axis, suggesting its potential in preventing vascular remodeling in PAH.

MOLECULAR MEDICINE REPORTS (2021)

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Article Oncology

Procyanidin B2 inhibits lipopolysaccharide-induced apoptosis by suppressing the Bcl-2/Bax and NF-κB signalling pathways in human umbilical vein endothelial cells

Da-Qiang Song et al.

Summary: PB2 pretreatment significantly reduced LPS-induced cytotoxicity and apoptosis in HUVECs, and modulated the expression levels of IL-1 beta, IL-6, TNF-alpha, Bax, cleaved caspase-3, cleaved caspase-7, cleaved caspase-9, etc. PB2 may exert its effects through the Bax/Bcl-2 and NF-kappa B signaling pathways, providing potential therapeutic benefits for infectious vascular diseases.

MOLECULAR MEDICINE REPORTS (2021)

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Article Orthopedics

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis

Z. Shao et al.

Summary: In vitro, QUE inhibits SASP factors expression and senescence phenotype in IL-10-treated NPCs. QUE suppresses IL-1 beta induced activation of the NF-kappa B pathway cascades. In vivo, QUE ameliorates the IDD process in the puncture-induced rat model.

OSTEOARTHRITIS AND CARTILAGE (2021)

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Review Microbiology

Nutraceutical Curcumin with Promising Protection against Herpesvirus Infections and Their Associated Inflammation: Mechanisms and Pathways

Miroslava Sudomova et al.

Summary: Curcumin shows potent anti-herpesvirus effects against various herpesviruses, offering promising potential for prevention and treatment of herpesvirus infections and their associated inflammatory diseases.

MICROORGANISMS (2021)

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Article Pharmacology & Pharmacy

Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice

Yuxin Jia et al.

Summary: This study demonstrates the protective effect of Hesperidin (HES) against arsenic trioxide-induced cardiotoxicity by inhibiting oxidative stress, inflammation, and apoptosis processes. The results show that HES acts through the regulation of the p62-Keap1-Nrf2 signaling pathway.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2)/System xc-/glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis

Shujun Xu et al.

Summary: Naringenin (NAR) has shown significant benefits in improving myocardial ischemia-reperfusion injury (MIRI) by regulating the Nrf2/System xc-/GPX4 axis to inhibit ferroptosis, demonstrating its potential as a therapeutic agent for heart injury.

BIOENGINEERED (2021)

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Article Biochemistry & Molecular Biology

Pretreatment with kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs?NF??B signaling pathway and pyroptosis after secondary spinal cord injury

Zhongyuan Liu et al.

Summary: The study showed that kaempferol improved hindlimb motor function recovery and reduced spinal cord tissue damage in SCI rats. It suppressed microglia activation and oxidative stress, down-regulating ROS dependent MAPKs-NF-?B and pyroptosis signaling pathways to attenuate oxidative stress and inflammation.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Agriculture, Multidisciplinary

Reparative Effects of Ethanol-Induced Intestinal Barrier Injury by Flavonoid Luteolin via MAPK/NF-κB/MLCK and Nrf2 Signaling Pathways

Jinwen Yuan et al.

Summary: The study showed that luteolin could alleviate ethanol-induced intestinal barrier damage by regulating the expression of tight junction proteins and inhibiting key signaling pathways. Additionally, luteolin acted as an indirect antioxidant to relieve oxidative damage and improve tight junction function.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Diosmin Alleviates Doxorubicin-Induced Liver Injury via Modulation of Oxidative Stress-Mediated Hepatic Inflammation and Apoptosis via NfkB and MAPK Pathway: A Preclinical Study

Abdullah F. AlAsmari et al.

Summary: The study showed that diosmin has a protective effect against doxorubicin-induced hepatotoxicity by restoring hepatic antioxidant factors, reducing inflammatory and apoptotic proteins and genes.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Chlorogenic Acid Attenuates Oxidative Stress-Induced Intestinal Epithelium Injury by Co-Regulating the PI3K/Akt and IκBα/NF-κB Signaling

Jiali Chen et al.

Summary: Chlorogenic acid (CGA) is a natural polyphenol compound with antioxidant and anti-inflammatory activities. It can attenuate oxidative stress-induced inflammation and injury in the intestinal epithelium by co-regulating the PI3K/Akt and IκBα/NF-κB signaling pathways.

ANTIOXIDANTS (2021)

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Article Pharmacology & Pharmacy

Chlorogenic acid ameliorates mice clinical endometritis by activating Keap1/Nrf2 and inhibiting NFκB signalling pathway

Feng Gao et al.

Summary: The study successfully established a mouse model of clinical endometritis using five LC uterine perfusions, and confirmed the anti-inflammatory and antioxidant effects of CGA.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

The gut microbiota metabolite urolithin A inhibits NF-κB activation in LPS stimulated BMDMs

Khalid N. M. Abdelazeem et al.

Summary: The research highlights that urolithin A (UA) shows promising therapeutic potential for treating inflammatory diseases by inhibiting pro-inflammatory molecules and NF-kappa B activation, as well as maintaining intracellular calcium and ROS homeostasis.

SCIENTIFIC REPORTS (2021)

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Article Immunology

Punicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-κB Pathway in the Experimental Study of Rheumatoid Arthritis

Mingcheng Huang et al.

Summary: The study demonstrated that punicalagin has anti-inflammatory and anti-bone destruction effects in rheumatoid arthritis by inhibiting the proliferation and migration of FLSs and modulating NF-kappa B pathways.

JOURNAL OF INFLAMMATION RESEARCH (2021)

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Article Environmental Sciences

Gallic acid suppresses inflammation and oxidative stress through modulating Nrf2-HO-1-NF-κB signaling pathways in elastase-induced emphysema in rats

Farzaneh Sohrabi et al.

Summary: This study investigated the protective role of gallic acid in elastase-induced emphysema by analyzing oxidative stress and inflammation markers. Gallic acid was found to preserve antioxidant activity and regulate the Nrf2 signaling pathway, suggesting its potential as a natural antioxidant agent for treating respiratory dysfunction caused by oxidative stress.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Article Chemistry, Medicinal

Xanthohumol alleviated T2DM-induced liver steatosis and fibrosis by mediating the NRF2/RAGE/NF-kappa B signaling pathway

Wei Wang et al.

Summary: Xanthohumol exhibits protective effects against T2DM-induced liver steatosis and fibrosis by mediating NRF2/AGE/RAGE/NF-kappa B signaling pathways.

FUTURE MEDICINAL CHEMISTRY (2021)

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Article Immunology

(-)-Epigallocatechin-3-gallate inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing NF-κB and MAPK signaling pathways

Huanhuan Xu et al.

Summary: EGCG in green tea can inhibit osteoclastogenesis by interfering with the interaction between RANK and RANKL, suppressing the phosphorylation of key regulatory factors, and negatively regulating NF-kappa B and MAPK signaling pathways.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Immunology

Taxifolin ameliorates Benzo[a]pyrene-induced lung injury possibly via stimulating the Nrf2 signalling pathway

Johirul Islam et al.

Summary: The study highlights the protective effect of Taxifolin on Benzo[a]pyrene-induced lung injury in mice, showing that Taxifolin suppresses oxidative stress and inflammation through stimulating the Nrf2 signaling pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Xanthohumol Attenuates Lipopolysaccharide-Induced Depressive Like Behavior in Mice: Involvement of NF-κB/Nrf2 Signaling Pathways

Shafiq Ur Rahman et al.

Summary: This study investigated the protective effects of xanthohumol (Xn) against LPS-induced depressive-like symptoms by examining neuroinflammation and oxidative stress markers in the hippocampus. Xn was found to reverse behavioral impairments, reduce neuroinflammation and oxidative stress, and modulate Nrf2 and NF-kappa B signaling pathways, showing potential as a prophylactic treatment for depression.

NEUROCHEMICAL RESEARCH (2021)

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Article Neurosciences

Formononetin attenuates H2O2-induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK-regulated apoptosis in neuronal SH-SY5Y cells

Mayuko Sugimoto et al.

Summary: Formononetin protects against H2O2-induced neuroblastoma cell death by reducing ROS levels and enhancing antioxidant gene expression through the activation of the PI3K/Akt-Nrf2 signaling pathway. Additionally, formononetin suppresses apoptosis by inhibiting MAPK phosphorylation in SH-SY5Y cells, suggesting its potential as a therapeutic agent for neurodegenerative diseases.

NEUROTOXICOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility

Aga Syed Sameer et al.

Summary: Toll-like receptors (TLRs) play important roles in gut inflammatory pathways and have a significant impact on the risk of colorectal cancer. This review comprehensively discusses the structure, functions, signaling of TLRs, and their role in CRC susceptibility.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Immunology

Protective effect of (+)-catechin against lipopolysaccharide-induced inflammatory response in RAW 264.7 cells through downregulation of NF-κB and p38 MAPK

M. A. Sunil et al.

Summary: The study demonstrated that catechin inhibited several inflammatory mediators in LPS-stimulated RAW 264.7 cells while also up-regulating IL-10 production. Furthermore, catechin down-regulated the mRNA expression of COX-2, iNOS, TNF-α, NF-κB, and p38 MAPK.

INFLAMMOPHARMACOLOGY (2021)

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Article Neurosciences

Pelargonidin ameliorates MCAO-induced cerebral ischemia/reperfusion injury in rats by the action on the Nrf2/HO-1 pathway

Kong Fu et al.

Summary: This study demonstrated that pelargonidin could effectively reduce cerebral ischemia volume, improve neurological function, and enhance memory and learning ability in MCAO rats. The mechanism of action may be related to the regulation of the Nrf2/HO-1 signaling pathway.

TRANSLATIONAL NEUROSCIENCE (2021)

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Article Nutrition & Dietetics

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo

Marta Cykowiak et al.

Summary: The study found that combinations of phytochemicals can enhance the activation and expression of Nrf2 and NF-κappa B, reduce NF-κappa B activity, and induce apoptosis in HCC cells. In a mouse model, X and PEITC or their combination were observed to reduce tumor burden.

NUTRIENTS (2021)

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Article Biochemistry & Molecular Biology

(-)-Epicatechin gallate blocks the development of atherosclerosis by regulating oxidative stress in vivo and in vitro

Jinjin Yu et al.

Summary: ECG reduces oxidative stress levels, improves lipid disruption, stabilizes atherosclerotic plaques, and may exhibit anti-atherosclerotic potential by inhibiting the NF-κB pathway, reducing inflammatory mediator expression, and decreasing lipid accumulation.

FOOD & FUNCTION (2021)

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Article Biochemistry & Molecular Biology

Rutin prevents inflammation-associated colon damage via inhibiting the p38/MAPKAPK2 and PI3K/Akt/GSK3β/NF-κB signalling axes and enhancing splenic Tregs in DSS-induced murine chronic colitis

Anamika Sharma et al.

Summary: The study shows the potential of rutin in treating chronic colitis by modulating multiple signaling pathways to improve disease symptoms and maintain intestinal health. Rutin not only alleviates tissue damage caused by colitis, but also regulates the expression of inflammatory proteins and controls immune responses.

FOOD & FUNCTION (2021)

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Article Veterinary Sciences

Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NF-κB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation

Mingjiang Liu et al.

Summary: The study revealed that ferulic acid (FA) has a protective effect on lipopolysaccharide (LPS)-induced bovine mammary epithelial cell (BMEC) apoptosis by restoring redox balance, inhibiting mitochondrial dysfunction, reducing oxidative stress, decreasing NF-kappa B activation, enhancing Nrf2 activation, and maintaining cell viability. Treatment with FA alone showed induction of Nrf2 activation before inhibition of NF-kappa B activation, suggesting that FA may prevent BMEC apoptosis by reversing the dominant relationship between NF-kappa B and Nrf2.

VETERINARY RESEARCH (2021)

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Article Plant Sciences

Esculin protects against methionine choline-deficient diet-induced non-alcoholic steatohepatitis by regulating the Sirt1/NF-κB p65 pathway

Xi-Ding Yang et al.

Summary: Esculin has hepatoprotective effects on MCD diet-induced NASH by regulating the Sirt1/ac-NF-κB signaling pathway. It could be employed as a therapy for NASH.

PHARMACEUTICAL BIOLOGY (2021)

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Article Plant Sciences

Taxifolin, a novel food, attenuates acute alcohol-induced liver injury in mice through regulating the NF-κB-mediated inflammation and PI3K/Akt signalling pathways

Chuanbo Ding et al.

Summary: The study demonstrated the hepatoprotective effect of TAX on acute alcohol-induced liver injury, as it could alleviate alcohol-induced hepatocyte necrosis and inflammatory infiltration. Additionally, it provides a potential treatment option for alcoholic liver disease in the future.

PHARMACEUTICAL BIOLOGY (2021)

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Article Pharmacology & Pharmacy

Rutin prevents inflammation induced by lipopolysaccharide in RAW 264.7 cells via conquering the TLR4-MyD88-TRAF6-NF-κB signalling pathway

Chunlian Tian et al.

Summary: The study focused on the anti-inflammatory activity of rutin in lipopolysaccharide-induced RAW 264.7 cells. Rutin was found to decrease iNOS expression, increase I kappa B expression, reduce expression of TLR4, MyD88, TRAF6 and p65, and inhibit phosphorylation of I kappa B and p65 as well as protein expression of TLR4, MyD88 and TRAF6. These results suggest that rutin may be beneficial as an adjuvant treatment for inflammatory diseases.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Ferulic acid alleviates lipopolysaccharide-induced acute lung injury through inhibiting TLR4/NF-κB signaling pathway

Xialei Wu et al.

Summary: The study suggests that ferulic acid can ameliorate LPS-induced acute lung injury by inhibiting the inflammatory response via inactivation of the TLR4/NF-kappa B signaling pathway.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

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Review Peripheral Vascular Disease

Is There a Difference in the Clinical Efficacy of Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disorders? Review of Available Evidence

Michele Cazaubon et al.

Summary: Based on a state-of-the-art literature review, both 600 mg of diosmin and 1000 mg of MPFF showed significant reduction in chronic venous disorder symptoms with similar efficacy, and were well tolerated by patients.

VASCULAR HEALTH AND RISK MANAGEMENT (2021)

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Article Dentistry, Oral Surgery & Medicine

Catechin ameliorates Porphyromonas gingivalis-induced inflammation via the regulation of TLR2/4 and inflammasome signaling

Hyun Ah Lee et al.

JOURNAL OF PERIODONTOLOGY (2020)

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Article Immunology

Apigenin exhibits anti-inflammatory effects in LPS-stimulated BV2 microglia through activating GSK3β/Nrf2 signaling pathway

Pengfei Chen et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2020)

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Article Cell Biology

Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway

Baoxiang Zhang et al.

CELL STRESS & CHAPERONES (2020)

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Review Biochemistry & Molecular Biology

Xanthones, A Promising Anti-Inflammatory Scaffold: Structure, Activity, and Drug Likeness Analysis

Zheling Feng et al.

MOLECULES (2020)

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Article Medicine, Research & Experimental

Osteoarthritis is Prevented in Rats by Verbascoside via Nuclear Factor kappa B (NF-κB) Pathway Downregulation

Hongbing Ma et al.

MEDICAL SCIENCE MONITOR (2020)

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Article Pharmacology & Pharmacy

Kaempferol Improves Lung Ischemia-Reperfusion Injury via Antiinflammation and Antioxidative Stress Regulated by SIRT1/HMGB1/NF-κB Axis

Chunli Yang et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Cell Biology

Esculetin Ameliorates Lipopolysaccharide-Induced Acute Lung Injury in Mice Via Modulation of the AKT/ERK/NF-κB and RORγt/IL-17 Pathways

Hung-Chen Lee et al.

INFLAMMATION (2020)

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Article Biochemistry & Molecular Biology

Inhibitory effect of diosmetin on inflammation and lipolysis in coculture of adipocytes and macrophages

Hana Lee et al.

JOURNAL OF FOOD BIOCHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis

Shuyun Wang et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2020)

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Article Biochemistry & Molecular Biology

Cyanidin Chloride Induces Apoptosis by Inhibiting NF-kappa B Signaling through Activation of Nrf2 in Colorectal Cancer Cells

Da-Young Lee et al.

ANTIOXIDANTS (2020)

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Review Allergy

Quercetin with the potential effect on allergic diseases

Morteza Jafarinia et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role

Dan Zhou et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Biochemistry & Molecular Biology

NRF2, a Transcription Factor for Stress Response and Beyond

Feng He et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Spiraeoside protects human cardiomyocytes against high glucose-induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway

Hongyang Liu et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2020)

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Review Cell Biology

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

Danping Zheng et al.

CELL DISCOVERY (2020)

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Article Cell Biology

Ellagic acid protects dopamine neurons from rotenone-induced neurotoxicity via activation of Nrf2 signalling

Yi-zheng Wei et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Cell Biology

Protection of procyanidin B2 on mitochondrial dynamics in sepsis associated acute kidney injury via promoting Nrf2 nuclear translocation

Jian-Xing Liu et al.

Aging-US (2020)

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Article Oncology

Echinacoside promotes the proliferation of human renal tubular epithelial cells by blocking the HBX/TREM2-mediated NF-κB signalling pathway

Yufan Zhang et al.

MOLECULAR MEDICINE REPORTS (2020)

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Article Biochemistry & Molecular Biology

Taxifolin ameliorates iron overload-induced hepatocellular injury: Modulating PI3K/AKT and p38 MAPK signaling, inflammatory response, and hepatocellular regeneration

Samir A. Salama et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

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Article Pharmacology & Pharmacy

Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways

Zhanjun Ma et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases

Toufic Kassouf et al.

BIOMOLECULES (2020)

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Article Pharmacology & Pharmacy

Vitexin restores pancreatic β-cell function and insulin signaling through Nrf2 and NF-κB signaling pathways

Kumar Ganesan et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

Natural Xanthones and Skin Inflammatory Diseases: Multitargeting Mechanisms of Action and Potential Application

Natalie Vivien Gunter et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

A study on the protective effects of taxifolin on human umbilical vein endothelial cells and THP-1 cells damaged by hexavalent chromium: a probable mechanism for preventing cardiovascular disease induced by heavy metals

Xiangyu Cao et al.

FOOD & FUNCTION (2020)

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Article Multidisciplinary Sciences

Modulation of Nrf2 by quercetin in doxorubicin-treated rats

Anish Sharma et al.

HELIYON (2020)

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Article Biochemistry & Molecular Biology

Variability of sinapic acid derivatives during germination and their contribution to antioxidant and anti-inflammatory effects of broccoli sprouts on human plasma and human peripheral blood mononuclear cells

Monika Anna Olszewska et al.

FOOD & FUNCTION (2020)

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Article Food Science & Technology

Traditional and modern uses of onion bulb (Allium cepa L.): a systematic review

Joaheer D. Teshika et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

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Article Immunology

Rosmarinic acid protects mice from lipopolysaccharide/D-galactosamine-induced acute liver injury by inhibiting MAPKs/NF-κB and activating Nrf2/HO-1 signaling pathways

Zheng Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Article Cell Biology

Tiliroside is a new potential therapeutic drug for osteoporosis in mice

Kai Li et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Medicine, Research & Experimental

Diosmetin Suppresses Neuronal Apoptosis and Inflammation by Modulating the Phosphoinositide 3-Kinase (PI3K)/AKT/Nuclear Factor-κB (NF-κB) Signaling Pathway in a Rat Model of Pneumococcal Meningitis

Yan Zhang et al.

MEDICAL SCIENCE MONITOR (2019)

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Review Pharmacology & Pharmacy

Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment

Runzhi Zhang et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Cell Biology

Caffeic Acid Prevented LPS-Induced Injury of Primary Bovine Mammary Epithelial Cells through Inhibiting NF-B and MAPK Activation

Mingjiang Liu et al.

MEDIATORS OF INFLAMMATION (2019)

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Article Biochemistry & Molecular Biology

Silibinin Downregulates the NF-B Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia

Mariana Leticia Matias et al.

MOLECULES (2019)

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Article Biotechnology & Applied Microbiology

Salicin inhirits AGE-induced degradation of type II collagen and aggrecan in human SW1353 chondrocytes: therapeutic potential in osteoarthritis

Feng Gao et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Vascular protection of salicin on IL-1β-induced endothelial inflammatory response and damages in retinal endothelial cells

Yu Song et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway

Wenyan Gao et al.

BIOMED RESEARCH INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

Protective effects of delphinidin against H2O2-induced oxidative injuries in human retinal pigment epithelial cells

Timin Ni et al.

BIOSCIENCE REPORTS (2019)

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Article Integrative & Complementary Medicine

ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress

Sung-Yong Yang et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Eriodictyol alleviates lipopolysaccharide-triggered oxidative stress and synaptic dysfunctions in BV-2 microglial cells and mouse brain

Pandi He et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Multidisciplinary Sciences

Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway

Xinyu Lin et al.

PLOS ONE (2019)

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Article Pharmacology & Pharmacy

Aesculin protects against DSS-Induced colitis though activating PPARγ and inhibiting NF-κB pathway

Xinlei Tiana et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Article Veterinary Sciences

Ferulic acid inhibits bovine endometrial epithelial cells against LPS-induced inflammation via suppressing NK-κB and MAPK pathway

Peng Yin et al.

RESEARCH IN VETERINARY SCIENCE (2019)

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Review Nutrition & Dietetics

Isoflavone Supplements for Menopausal Women: A Systematic Review

Li-Ru Chen et al.

NUTRIENTS (2019)

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Article Multidisciplinary Sciences

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