☆ 4.7 Article

Differentially Expressed Genes and Molecular Susceptibility to Human Age-Related Diseases

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biochemistry & Molecular Biology

Glycogen accumulation and phase separation drives liver tumor initiation

Qingxu Liu et al.

Summary: Glucose consumption is increased in tumor cells to support tumor growth, while glycogen accumulation plays a crucial role in liver malignant transformation. Glycogen accumulation blocks Hippo signaling and enhances tumor incidence in cancer-initiating cells.

CELL (2021)

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Review Biochemistry & Molecular Biology

The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases

Yoshimi Kishimoto et al.

Summary: Sestrin2, an anti-oxidant protein induced by various stresses, plays a protective role against oxidative damage and may serve as a potential therapeutic target for the treatment of atherosclerosis. High blood sestrin2 levels in patients with atherosclerotic diseases may reflect a compensatory response to increased oxidative stress, aiding in the protection against disease progression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biotechnology & Applied Microbiology

PDIA4 Correlates with Poor Prognosis and is a Potential Biomarker in Glioma

Haoyu Li et al.

Summary: This study identified high PDIA4 expression in gliomas associated with poor prognosis. PDIA4 interacted with multiple immunological components to promote an immunosuppressive tumor microenvironment. Knockdown of PDIA4 significantly impaired the proliferation of GBM cells.

ONCOTARGETS AND THERAPY (2021)

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Review Oncology

Autophagy Regulation and Photodynamic Therapy: Insights to Improve Outcomes of Cancer Treatment

Waleska K. Martins et al.

Summary: The article summarizes the importance and challenges of photodynamic therapy in cancer treatment, emphasizing the role of autophagy regulation in the process and exploring the molecular mechanisms that evoke PDT resistance in tumor cells. The study provides insights into how PDT modulates autophagy and highlights this field as a promising strategy for cancer treatment.

FRONTIERS IN ONCOLOGY (2021)

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Article Cell Biology

BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma

Ying Yang et al.

Aging-US (2021)

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Review Cell Biology

Tissue-resident macrophage inflammaging aggravates homeostasis dysregulation in age-related diseases

Ziqi Yue et al.

Summary: Tissue-resident macrophages isolated from aged animals or patients show alterations that are closely associated with age-related diseases, leading to inflammaging and chronic diseases. These defects contribute to a loss of tissue-repair capacity and a senescence-associated secretory phenotype in cells.

CELLULAR IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Phylogeny and evolution of mycophagy in the Zygothrica genus group (Diptera: Drosophilidae)

Yang Zhang et al.

Summary: Through phylogenetic analysis of the family Drosophilidae, the study reveals the evolutionary history of the Zygothrica genus group and the significant role of mycophagy in family evolution. The Zygothrica genus group is shown to be monophyletic, with its relationships within the Drosophilidae subfamilies and the evolution of fungus-feeding habits among different lineages elucidated. This study also provides insights into the origin and diversification of mycophagy within the Drosophilidae family.

MOLECULAR PHYLOGENETICS AND EVOLUTION (2021)

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Article Biochemistry & Molecular Biology

A Bioinformatics Model of Human Diseases on the Basis of Differentially Expressed Genes (of Domestic Versus Wild Animals) That Are Orthologs of Human Genes Associated with Reproductive-Potential Changes

Gennady Vasiliev et al.

Summary: The researchers found a reliable association between changes in gene expression in domestic and wild animals with human reproductive potential and their orthologous genes, while gene expression in wild animals better aligns with the normal state of human reproductive potential.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Virology

African Swine Fever Virus Circulation between Tanzania and Neighboring Countries: A Systematic Review and Meta-Analysis

Jean N. Hakizimana et al.

Summary: The study systematically reviewed the molecular epidemiology of African swine fever (ASF) in Tanzania and its eight neighboring countries, revealing ongoing circulation of ASFV and multiple transboundary spread events between these countries. The findings emphasize the need for further research to enhance understanding of virus transmission dynamics and highlight the importance of a regional approach to control ASFV spread.

VIRUSES-BASEL (2021)

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Review Cell Biology

Obesity and aging: Molecular mechanisms and therapeutic approaches

Ana L. Santos et al.

Summary: Obesity poses a major challenge for health policymakers due to its increased risk of acute and chronic diseases and potential financial burden on healthcare systems. The metabolic dysregulation associated with obesity is similar to that observed in normal aging, suggesting the potential for obesity to accelerate aging. Understanding the molecular and cellular mechanisms underlying obesity and aging could provide insights into the development of chronic health complications.

AGEING RESEARCH REVIEWS (2021)

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Article Geriatrics & Gerontology

Production and scavenging of reactive oxygen species both affect reproductive success in male and female Drosophila melanogaster

Biz R. Turnell et al.

Summary: Limiting ROS production and increasing antioxidant production can slow sperm aging; Experiment with fruit flies suggest that reducing ROS production or scavenging ROS can affect reproductive fitness; Female ROS levels may affect aging rates in stored sperm and/or eggs.

BIOGERONTOLOGY (2021)

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Article Biology

Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons

David Sokolov et al.

Summary: This study reveals the previously unrecognized complexity in NMNAT1-associated retinal degeneration, indicating a potential role for NMNAT1 in gene regulation during photoreceptor terminal differentiation. Deletion of nuclear-localized NAD(+) synthase NMNAT1 in developing murine retina leads to early and severe degeneration of photoreceptors and inner retinal neurons, associated with disruptions in central carbon metabolism, purine nucleotide synthesis, and amino acid pathways. Dysregulation of photoreceptor and synapse-specific genes in NMNAT1 knockout retinas is observed prior to detectable morphological or metabolic alterations.

ELIFE (2021)

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Review Biochemistry & Molecular Biology

The aging lung: Physiology, disease, and immunity

Jaime L. Schneider et al.

Summary: Human population is aging faster than ever before in history, requiring a deeper understanding of aging biology and its connection to diseases. Aging lungs face various stresses, increasing the risk of lung diseases, respiratory infections, and lung cancer.

CELL (2021)

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Article Genetics & Heredity

Transcriptomic Analysis of Laying Hens Revealed the Role of Aging-Related Genes during Forced Molting

Tongyu Zhang et al.

Summary: Forced molting in chickens can restart the reproductive function of aged hens by regulating expression levels of genes associated with aging and development. This study provides insights for antiaging research in humans and the conception mechanism in elderly women.

GENES (2021)

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Article Biotechnology & Applied Microbiology

Integral membrane protein 2A enhances sensitivity to chemotherapy via notch signaling pathway in cervical cancer

Yan Li et al.

Summary: ITM2A is downregulated in cervical tumor tissues and associated with poor survival; Overexpression of ITM2A increases the sensitivity of cervical cancer cells to cisplatin; ITM2A may mediate cisplatin-resistant cervical cancer through the Notch signaling pathway.

BIOENGINEERED (2021)

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Article Cell Biology

Disruption of Circadian Rhythms by Ambient Light during Neurodevelopment Leads to Autistic-like Molecular and Behavioral Alterations in Adult Mice

Kun Fang et al.

Summary: A study using the Short Day (SD) mouse model found that chronic disruption of circadian rhythms during neurodevelopment can lead to molecular, cellular, and behavioral changes resembling autistic-like phenotypes. This highlights a critical role for circadian rhythms in neurodevelopment.

CELLS (2021)

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Article Cell Biology

RETSAT Mutation Selected for Hypoxia Adaptation Inhibits Tumor Growth

Xiulin Jiang et al.

Summary: Hypoxia is associated with various natural environments and human pathological conditions, including hypoxic solid tumors. The study identified RETSAT as a novel gene critical for solid tumor growth, with its expression being downregulated in multiple human cancers due to promoter region hypermethylation. Functional studies showed that RETSAT knockdown promotes cell proliferation, while its overexpression inhibits proliferation, indicating its potential role in tumor growth regulation.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Hematology

Abnormal hemoglobin H band in myelodysplastic syndromes (MDS): A case report

Cong Liu et al.

Summary: Myelodysplastic syndrome (MDS) is a heterogeneous disease derived from hematopoietic stem cells, commonly seen in patients over 60 years old, presenting with symptoms such as anemia, infection, and bleeding. Abnormal hematopoiesis can lead to HbH disease, and a small number of patients may have concurrent acute myeloid leukemia.

TRANSFUSION CLINIQUE ET BIOLOGIQUE (2021)

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Article Genetics & Heredity

Skeletal Muscle Gene Expression Profile in Response to Caloric Restriction and Aging: A Role for SirT1

Matthew J. Myers et al.

Summary: The study found that aging affects the role of CR in muscle, with CR restoring global gene expression inhibition caused by aging by upregulating transcriptional and translational process-related pathways. However, CR inhibits pathways related to extracellular matrix and cytoskeletal proteins regardless of aging.

GENES (2021)

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Article Geriatrics & Gerontology

The Pathways to Healthy Ageing: Evidence From Longitudinal Studies and Real-Time Data

Terry Y S Lum

Innovation in Aging (2021)

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Article Medicine, General & Internal

Age-related macular degeneration

Monika Fleckenstein et al.

Summary: Age-related macular degeneration (AMD) is the leading cause of legal blindness in the industrialized world, with a complex pathophysiology involving aging, environmental factors, and genetic susceptibility leading to photoreceptor degeneration and drusen formation. Tailoring therapeutics to specific phenotypes and stages may be crucial for preventing irreversible vision loss in the future.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Agriculture, Dairy & Animal Science

Validation of Reference Genes via qRT-PCR in Multiple Conditions in Brandt's Voles, Lasiopodomys brandtii

Lin Tian et al.

Summary: The study validated the stability of nine common candidate reference genes in different tissues, developmental stages, and photoperiods using qRT-PCR. None of the genes were suitable as optimal reference genes across all conditions, highlighting the challenge in selecting reference genes due to their varied expression patterns in different contexts.

ANIMALS (2021)

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Review Pharmacology & Pharmacy

Extracellular vesicles from mesenchymal stromal cells: Therapeutic perspectives for targeting senescence in osteoarthritis

Jeremy Boulestreau et al.

Summary: Osteoarthritis is associated with a high number of senescent cells in joint tissues, which release senescence-associated secretory phenotype (SASP) factors contributing to the disease progression. Targeting senescent cells has shown improvement in OA features in mouse models. MSCs and MSC-EVs are promising treatments for OA, but their functions are affected by aging.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Cell Biology

Senescence in tissue samples of humans with age-related diseases: A systematic review

Camilla S. L. Tuttle et al.

Summary: This systematic review provides an overview of the evidence on senescent cells in age-related disease pathologies in humans, as well as the markers currently used to detect senescence levels. The study found that senescence plays an important role in disease pathologies in different organ systems and age-related diseases, particularly in the heart and respiratory systems. The expression levels of senescence markers also vary in different diseases.

AGEING RESEARCH REVIEWS (2021)

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Article Oncology

Aging of the progenitor cells that initiate prostate cancer

Jack Freeland et al.

Summary: The prostate continues to grow in volume while many other organs experience a loss of tissue mass and decline in regenerative capacity during aging. Research indicates that prostate luminal progenitor cells expand with age, and age-related changes to the microenvironment may influence prostate epithelial cells and the risk of transformation. Addressing questions regarding models of aging and regulators of prostate aging is crucial for understanding mechanisms that promote age-related prostatic disease.

CANCER LETTERS (2021)

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Article Chemistry, Medicinal

Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis

Jinxin Che et al.

Summary: The compound 4 was identified as a WSB1 degrader, inhibiting the migration capacity of WSB1-overexpressing cells and showing promising anticancer metastatic effects in vivo.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Multidisciplinary Sciences

HAI-1 is an independent predictor of lung cancer mortality and is required for M1 macrophage polarization

Stanley Borowicz et al.

Summary: The loss of tumor suppressor gene HAI-1 leads to poor prognosis in NSCLC patients, characterized by increased M2 macrophages in the tumor microenvironment. This mechanism may contribute to an immunosuppressive M2-dominated TME through impaired M1 macrophage polarization. This suggests HAI-1 status could be informative for stratifying patients who may benefit from therapies targeting the HGF pathway, particularly as an adjuvant to ICI-based immunotherapy.

PLOS ONE (2021)

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Review Environmental Sciences

Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds

Andrea Figuer et al.

Summary: Aging is an inevitable, multifactorial process characterized by progressive and irreversible physiological changes. Factors such as oxidative stress, inflammation, cellular senescence, and frailty contribute to human body deterioration in aging.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Endocrinology & Metabolism

The association between age at diagnosis of type 2 diabetes and albuminuria in Chinese adults: A nationwide population study

Shujing Wu et al.

Summary: The study from China shows that being diagnosed with type 2 diabetes at a younger age is associated with a higher risk of albuminuria compared to being diagnosed at an older age. As age at diagnosis increases, the risk of albuminuria decreases in Chinese adults.

JOURNAL OF DIABETES (2021)

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Article Physiology

Molecular Characterization and Elucidation of Pathways to Identify Novel Therapeutic Targets in Pulmonary Arterial Hypertension

Xiaoting Yao et al.

Summary: By integrating two microarray datasets, this study identified 38 common DEGs in PAH, highlighting hub genes, TFs, and miRNAs. Protein-drug interactions revealed potential compounds impacting PAH candidate biomolecules, with molecular signatures predominantly localized in extracellular and nuclear areas. These lung tissue-derived molecular signatures could offer novel insights into the mechanisms of PAH and aid in the development of diagnostic and therapeutic strategies.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Immunology

The Role of Hemoglobin Subunit Delta in the Immunopathy of Multiple Sclerosis: Mitochondria Matters

Afshin Derakhshani et al.

Summary: Mitochondrial stress may play a role in the development of multiple sclerosis (MS), with HBD identified as a significantly up-regulated gene in the PBMCs of MS patients. Treatment-naive MS patients showed higher expression of HBD, which was significantly decreased with immunomodulatory therapies. Further investigations are needed to understand the molecular mechanisms of HBD in MS patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Clinical Neurology

High PYGL Expression Predicts Poor Prognosis in Human Gliomas

Chang-yi Zhao et al.

Summary: This study found that high expression of PYGL is positively associated with glioma malignancy and serves as an independent predictor of poor prognosis in patients with glioma. The study used bioinformatics analysis to identify potential mechanisms underlying the predictive value of PYGL in gliomas, with different gene sets related to signaling pathways and angiogenesis enriched in high PYGL expression phenotype. Single-cell sequencing data analysis further confirmed the high expression of PYGL in specific cell groups, including tumor-associated macrophages and malignant cells.

FRONTIERS IN NEUROLOGY (2021)

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Article Genetics & Heredity

Disruptive Selection of Human Immunostimulatory and Immunosuppressive Genes Both Provokes and Prevents Rheumatoid Arthritis, Respectively, as a Self-Domestication Syndrome

Natalya Klimova et al.

Summary: Genome-wide analysis of SNPs in human rheumatoid arthritis-related genes revealed potential SNP markers for both overexpression and underexpression of genes, with different patterns in immunostimulatory and immunosuppressive genes. This suggests that natural selection may play a role in shaping susceptibility to RA.

FRONTIERS IN GENETICS (2021)

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Article Endocrinology & Metabolism

Comprehensive Analysis of the Expression and Prognostic Value of SPINT1/2 in Breast Carcinoma

Qiulin Wu et al.

Summary: The study found that SPINT1/2 were upregulated in breast cancer, associated with HER2 and node positive patients, and significantly correlated with a poorer prognosis. SPINT1/2 were reciprocally correlated and played a role in regulating cell attachment and migration.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Oncology

Immune Microenvironment Signatures as Biomarkers to Predict Early Recurrence of Stage Ia-b Lung Cancer

Qiang Wang et al.

Summary: This study identified immune cell types and immune-related genes associated with tumor early recurrence in stage Ia-b NSCLC patients. The combination of five immune-related genes showed high sensitivity and specificity for predicting early recurrence of lung cancer in the training cohort, with varying performance in the validation cohorts. These findings suggest that immune-related gene expression may serve as robust biomarkers for predicting early recurrence in stage Ia-b NSCLC patients after curative resection.

FRONTIERS IN ONCOLOGY (2021)

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Article Agriculture, Dairy & Animal Science

Domestication Explains Two-Thirds of Differential-Gene-Expression Variance between Domestic and Wild Animals; The Remaining One-Third Reflects Intraspecific and Interspecific Variation

Irina Chadaeva et al.

Summary: Genomic patterns of animal domestication show commonalities across species, with majority of genes exhibiting similar expression changes. Domestic environments alter gene activities akin to human diseases, while natural environments maintain normal gene expression in wild animals. Belyaev's concept of destabilizing selection during domestication has practical applications in commercial breeding and disease modeling.

ANIMALS (2021)

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Review Geriatrics & Gerontology

Role of heat shock proteins in aging and chronic inflammatory diseases

Christian R. Gomez

Summary: Aging is associated with a decrease in response to stress, leading to chronic inflammation and diseases. Heat shock proteins (HSP) play a crucial role in age-related pathology linked to chronic inflammation, offering a potential target for delaying age-related chronic disorders.

GEROSCIENCE (2021)

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Article Biochemistry & Molecular Biology

Neuromedin B modulates phosphate-induced vascular calcification

Hyun-Joo Park et al.

Summary: The study found that in phosphate-induced vascular smooth muscle cell calcification, the expression of neuromedin B and NMB receptor is upregulated, suggesting the potential therapeutic value of the NMB-NMB receptor axis.

BMB REPORTS (2021)

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Article Oncology

High Expression of RhoBTB3 Predicts Favorable Chemothrapy Outcomes in non-M3 Acute Myeloid Leukemia

Shuang-Hui Yang et al.

Summary: The study identified RhoBTB3 as a prognostic marker for non-M3 AML patients, aiding in treatment options selection between chemotherapy and allo-HCST. Allo-HSCT could improve prognosis in cases of RhoBTB3 downregulation, while high RhoBTB3 mRNA expression served as an independent favorable prognostic factor in chemotherapy patients.

JOURNAL OF CANCER (2021)

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Review Psychology, Multidisciplinary

Ten Years of Research on Automatic Voice and Speech Analysis of People With Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review Article

Israel Martinez-Nicolas et al.

Summary: The field of voice and speech analysis has gained popularity in detecting neurodegenerative diseases like Alzheimer's and mild cognitive impairment. Studies have found that speech analysis is a cost-effective and reliable method with high diagnostic accuracy for distinguishing between healthy aging and cognitive disorders. Researchers have identified specific speech features that can effectively diagnose these conditions.

FRONTIERS IN PSYCHOLOGY (2021)

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Article Clinical Neurology

2021 Alzheimer's disease facts and figures

[Anonymous]

Summary: Alzheimer's disease has a significant impact on individuals and society as a whole, with a large number of patients in the United States and a potential for continued growth in the future. The value of unpaid caregivers has increased despite a decline in their numbers, and healthcare costs are on the rise. Racial and ethnic disparities in healthcare persist, highlighting the need for greater diversity in dementia care workforce and clinical trials.

ALZHEIMERS & DEMENTIA (2021)

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Review Geriatrics & Gerontology

Neuroimaging markers of chronic fatigue in older people: a narrative review

Davide Angioni et al.

Summary: Currently, there is limited research on the associations between fatigue and neuroimaging markers in older adults. Studies suggest that fatigue is linked to changes in the hippocampus, basal ganglia networks, and white matter integrity. Further research is needed to explore these associations in depth.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2021)

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Review Urology & Nephrology

The global burden of urinary bladder cancer: an update

Anke Richters et al.

WORLD JOURNAL OF UROLOGY (2020)

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Article Medicine, Research & Experimental

Normal Aging and Its Role in Cancer Metastasis

Mitchell Fane et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2020)

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Article Neurosciences

Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Akram Zamani et al.

BRAIN RESEARCH BULLETIN (2020)

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Article Allergy

Eczema Herpeticum: Clinical and Pathophysiological Aspects

Alexia Damour et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2020)

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Review Oncology

Acute Myeloid Leukemia: Aging and Epigenetics

Polina Zjablovskaja et al.

CANCERS (2020)

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Review Peripheral Vascular Disease

Mitophagy in Hypertension-Associated Premature Vascular Aging

Zachary J. Schreckenberger et al.

AMERICAN JOURNAL OF HYPERTENSION (2020)

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Article History & Philosophy Of Science

Human domestication and the roles of human agency in human evolution

Lorenzo Del Savio et al.

HISTORY AND PHILOSOPHY OF THE LIFE SCIENCES (2020)

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Article Genetics & Heredity

Phylodynamics of G4P[8] and G2P[4] strains of rotavirus A isolated in Russia in 2017 based on full-genome analyses

Olga V. Morozova et al.

VIRUS GENES (2020)

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Article Multidisciplinary Sciences

CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes

Eric A. Evangelista et al.

SCIENTIFIC REPORTS (2020)

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Article Medicine, General & Internal

Potential mechanisms and serum biomarkers involved in sex differences in pulmonary arterial hypertension

Chan Li et al.

MEDICINE (2020)

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Article Biotechnology & Applied Microbiology

Gene expression within the periaqueductal gray is linked to vocal behavior and early-onset parkinsonism in Pink1 knockout rats

Cynthia A. Kelm-Nelson et al.

BMC GENOMICS (2020)

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Article Anesthesiology

Loss of SLC9A6/NHE6 impairs nociception in a mouse model of Christianson syndrome

Hugues Petitjean et al.

PAIN (2020)

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Article Pharmacology & Pharmacy

Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model

Jian Lu et al.

DRUG METABOLISM AND DISPOSITION (2020)

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Article Evolutionary Biology

Brain Transcriptomics of Wild and Domestic Rabbits Suggests That Changes in Dopamine Signaling and Ciliary Function Contributed to Evolution of Tameness

Daiki X. Sato et al.

GENOME BIOLOGY AND EVOLUTION (2020)

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Article Clinical Neurology

Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer's dementia

Elin Byman et al.

ALZHEIMERS RESEARCH & THERAPY (2020)

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Review Peripheral Vascular Disease

Origins of Primary Hypertension in Children Early Vascular or Biological Aging?

Mieczyslaw Litwin et al.

HYPERTENSION (2020)

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Article Ecology

Changes in pituitary gene expression may underlie multiple domesticated traits in chickens

Amir Fallahshahroudi et al.

HEREDITY (2019)

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Article Geriatrics & Gerontology

The Rat Prefrontal-Cortex Transcriptome: Effects of Aging and Sporadic Alzheimers DiseaseLike Pathology

Natalia A. Stefanova et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)

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Article Biochemical Research Methods

A new version of the ANDSystem tool for automatic extraction of knowledge from scientific publications with expanded functionality for reconstruction of associative gene networks by considering tissue-specific gene expression

Vladimir A. Ivanisenko et al.

BMC BIOINFORMATICS (2019)

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Article Biotechnology & Applied Microbiology

The differences in brain stem transcriptional profiling in hypertensive ISIAH and normotensive WAG rats

Larisa A. Fedoseeva et al.

BMC GENOMICS (2019)

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Article Biochemistry & Molecular Biology

The effects of endothelium-specific CYP2J2 overexpression on the attenuation of retinal ganglion cell apoptosis in a glaucoma rat model

Jingqiu Huang et al.

FASEB JOURNAL (2019)

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Article Endocrinology & Metabolism

Changes in Musculoskeletal System and Metabolism in Osteoporotic Rats Treated With Urocortin

Dominik Saul et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Article Cell Biology

Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction

Cefan Zhou et al.

CELL COMMUNICATION AND SIGNALING (2019)

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Review Medicine, General & Internal

Colorectal cancer

Evelien Dekker et al.

LANCET (2019)

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Article Biochemistry & Molecular Biology

Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome

Robert S. Stearman et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

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Article Genetics & Heredity

Phylostratigraphic Analysis Shows the Earliest Origination of the Abiotic Stress Associated Genes in A. thaliana

Zakhar S. Mustafin et al.

GENES (2019)

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Article Cell Biology

Genetical modification on adipose-derived stem cells facilitates facial nerve regeneration

Jian Tan et al.

AGING-US (2019)

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Article Medicine, General & Internal

Increased Reactive Oxygen Species Generation Contributes to the Atherogenic Activity of the B2 Bradykinin Receptor

Alexander Perhal et al.

FRONTIERS IN MEDICINE (2019)

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Review Oncology

Aging, Cancer and Immunity

Hong Hong et al.

JOURNAL OF CANCER (2019)

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Article Cell Biology

Sex differences in transcriptomic profiles in aged kidney cells of renin lineage

Yuliang Wang et al.

AGING-US (2018)

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Article Agriculture, Dairy & Animal Science

Comparative analysis of the blood transcriptomes between wolves and dogs

X. Yang et al.

ANIMAL GENETICS (2018)

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Article Agriculture, Dairy & Animal Science

Transcriptome differences in frontal cortex between wild boar and domesticated pig

Keren Long et al.

ANIMAL SCIENCE JOURNAL (2018)

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Article Biochemistry & Molecular Biology

Glycogen at the Crossroad of Stress Resistance, Energy Maintenance, and Pathophysiology of Aging

Ivan Gusarov et al.

BIOESSAYS (2018)

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Article Biotechnology & Applied Microbiology

Association of cerebrovascular dysfunction with the development of Alzheimer's disease-like pathology in OXYS rats

Natalia A. Stefanova et al.

BMC GENOMICS (2018)

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Article Biochemistry & Molecular Biology

Age-Specific Association of CCL5 Gene Polymorphism with Pulmonary Tuberculosis: A Case-Control Study

Alexander Varzari et al.

GENETIC TESTING AND MOLECULAR BIOMARKERS (2018)

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Article Oncology

CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia

Jinghua Wang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Article Multidisciplinary Sciences

Normal aging induces A1-like astrocyte reactivity

Laura E. Clarke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Multidisciplinary Sciences

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control

Jin-Yu Yang et al.

NATURE COMMUNICATIONS (2018)

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Review Cell Biology

Transmembrane domain dependent inhibitory function of FcRIIB

Junyi Wang et al.

PROTEIN & CELL (2018)

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Article Cell Biology

WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation

Jung Jin Kim et al.

CELL RESEARCH (2017)

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Article Biochemistry & Molecular Biology

MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search

Noa Rappaport et al.

NUCLEIC ACIDS RESEARCH (2017)

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Review Veterinary Sciences

Natural mortality and cause of death analysis of the captive chimpanzee (Pan troglodytes): A 35-year review

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Article Cell Biology

Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes

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MOLECULAR AND CELLULAR ENDOCRINOLOGY (2017)

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Article Biochemistry & Molecular Biology

Global gene expression changes in the prefrontal cortex of rabbits with hypercholesterolemia and/or hypertension

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NEUROCHEMISTRY INTERNATIONAL (2017)

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Self-domestication in Homo sapiens: Insights from comparative genomics

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PLOS ONE (2017)

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Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis

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NATURE COMMUNICATIONS (2017)

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RNA-seq analysis of the kidneys of broiler chickens fed diets containing different concentrations of calcium

Woncheoul Park et al.

SCIENTIFIC REPORTS (2017)

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Article Oncology

Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients

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MOLECULAR AND CLINICAL ONCOLOGY (2017)

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Review Pathology

Composite intestinal adenoma-microcarcinoid in the colon and rectum: a case series and historical review

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DIAGNOSTIC PATHOLOGY (2017)

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Review Cell Biology

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AGEING RESEARCH REVIEWS (2017)

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Orthoscape: a cytoscape application for grouping and visualization KEGG based gene networks by taxonomy and homology principles

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BMC BIOINFORMATICS (2017)

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EMX2 gene expression predicts liver metastasis and survival in colorectal cancer

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BMC CANCER (2017)

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The gene-expression profile of renal medulla in ISIAH rats with inherited stress-induced arterial hypertension

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BMC GENETICS (2016)

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Article Genetics & Heredity

Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension

Leonid O. Klimov et al.

BMC GENETICS (2016)

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Article Genetics & Heredity

Comparative transcriptional profiling of renal cortex in rats with inherited stress-induced arterial hypertension and normotensive Wistar Albino Glaxo rats

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BMC GENETICS (2016)

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Article Biotechnology & Applied Microbiology

Molecular determinants of the adrenal gland functioning related to stress-sensitive hypertension in ISIAH rats

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BMC GENOMICS (2016)

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Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer

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JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Review Urology & Nephrology

Autophagy in kidney disease and aging: lessons from rodent models

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KIDNEY INTERNATIONAL (2016)

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Review Immunology

Tissue biology perspective on macrophages

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NATURE IMMUNOLOGY (2016)

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AP1 transcription factors are required to maintain the peripheral taste system

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CELL DEATH & DISEASE (2016)

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Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis

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ONCOTARGET (2016)

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CompGO: an R package for comparing and visualizing Gene Ontology enrichment differences between DNA binding experiments

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Reversible induction of translational isoforms of p53 in glucose deprivation

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WORLD JOURNAL OF GASTROENTEROLOGY (2015)

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CURRENT ONCOLOGY REPORTS (2015)

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Exome Sequencing in an Admixed Isolated Population Indicates NFXL1 Variants Confer a Risk for Specific Language Impairment

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PLOS GENETICS (2015)

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Article Biotechnology & Applied Microbiology

How to Use SNP_TATA_Comparator to Find a Significant Change in Gene Expression Caused by the Regulatory SNP of This Gene's Promoter via a Change in Affinity of the TATA-Binding Protein for This Promoter

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BIOMED RESEARCH INTERNATIONAL (2015)

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HTSeq-a Python framework to work with high-throughput sequencing data

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Domesticated animals and human infectious diseases of zoonotic origins: Domestication time matters

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INFECTION GENETICS AND EVOLUTION (2014)

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Deficiency of slow skeletal muscle troponin T causes atrophy of type I slow fibres and decreases tolerance to fatigue

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JOURNAL OF PHYSIOLOGY-LONDON (2014)

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RUSSIAN JOURNAL OF GENETICS (2014)

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EPMA JOURNAL (2014)

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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

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Phosphotriesterase-related protein sensed albuminuria and conferred renal tubular cell activation in membranous nephropathy

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Review Immunology

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Rat retinal transcriptome Effects of aging and AMD-like retinopathy

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CELL CYCLE (2013)

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GENETICS AND MOLECULAR RESEARCH (2013)

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Human -Defensin 2 Is a Novel Opener of Ca2+-Activated Potassium Channels and Induces Vasodilation and Hypotension in Monkeys

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HYPERTENSION (2013)

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Knockdown of Prodynorphin Gene Prevents Cognitive Decline, Reduces Anxiety, and Rescues Loss of Group 1 Metabotropic Glutamate Receptor Function in Aging

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JOURNAL OF NEUROSCIENCE (2013)

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M-Protein Is Down-Regulated in Cardiac Hypertrophy Driven by Thyroid Hormone in Rats

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MOLECULAR ENDOCRINOLOGY (2013)

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NCBI GEO: archive for functional genomics data sets-update

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NUCLEIC ACIDS RESEARCH (2013)

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Article Biotechnology & Applied Microbiology

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

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Review Hematology

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Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases

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BRAIN RESEARCH (2012)

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Review Cardiac & Cardiovascular Systems

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A Comparison of Brain Gene Expression Levels in Domesticated and Wild Animals

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PLOS GENETICS (2012)

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Medical Management of Frontotemporal Dementias: The Importance of the Caregiver in Symptom Assessment and Guidance of Treatment Strategies

Gregory A. Jicha

JOURNAL OF MOLECULAR NEUROSCIENCE (2011)

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Oral melanotic macule and primary oral malignant melanoma: Epidemiology, location involved, and clinical implications

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ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY (2011)

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Review Mathematical & Computational Biology

PubMed and beyond: a survey of web tools for searching biomedical literature

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DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2011)

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Human Nephrosclerosis Triggers a Hypoxia-Related Glomerulopathy

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AMERICAN JOURNAL OF PATHOLOGY (2010)

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Editorial Material Genetics & Heredity

dbSNP in the Detail and Copy Number Complexities

Ian N. M. Day

HUMAN MUTATION (2010)

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Transcriptome profiling and network analysis of genetically hypertensive mice identifies potential pharmacological targets of hypertension

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PHYSIOLOGICAL GENOMICS (2010)

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A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Biotechnology & Applied Microbiology

Differential expression analysis for sequence count data

Simon Anders et al.

GENOME BIOLOGY (2010)

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Editorial Material Clinical Neurology

β-thalassemia Trait as a Protective Factor Against Alzheimer Disease

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ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2009)

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The TATA-Binding Protein Core Domain in Solution Variably Bends TATA Sequences via a Three-Step Binding Mechanism

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BIOCHEMISTRY (2009)

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Article Biochemical Research Methods

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BIOINFORMATICS (2009)

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The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

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CLINICAL CHEMISTRY (2009)

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Retinol saturase promotes adipogenesis and is downregulated in obesity

Michael Schupp et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Biochemistry & Molecular Biology

A step-by-step model of TBP/TATA box binding allows predicting human hereditary diseases by single nucleotide polymorphism

P. M. Ponomarenko et al.

DOKLADY BIOCHEMISTRY AND BIOPHYSICS (2008)

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Article Microbiology

Triosephosphate isomerase genes in two trophic modes of euglenoids (Euglenophyceae) and their phylogenetic analysis

Gui-Ling Sun et al.

JOURNAL OF EUKARYOTIC MICROBIOLOGY (2008)

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Article Immunology

A validation of 10 feline reference genes for gene expression measurements in snap-frozen tissues

Louis C. Penning et al.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2007)

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Resistance Exercise Reverses Aging in Human Skeletal Muscle

Simon Melov et al.

PLOS ONE (2007)

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Article Biochemistry & Molecular Biology

Genetics of human longevity with emphasis on the relevance of HSP70 as candidate genes

Ripudaman Singh et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2007)

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Membranous nephropathy in the older adult - Epidemiology, diagnosis and management

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DRUGS & AGING (2007)

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Review Neurosciences

Enhanced Purkinje cell survival but compromised cerebellar function in targeted anti-apoptotic protein transgenic mice

J Goswami et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2005)

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Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells

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CANCER LETTERS (2004)

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Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo

CS Samuel et al.

ENDOCRINOLOGY (2004)

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Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

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The bioperl toolkit:: Perl modules for the life sciences

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GENOME RESEARCH (2002)

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Urocortin

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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2002)

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