期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ijms24087614
关键词
cell cycle regulation; chemotherapy; fibrosis; ionizing radiation; radiomitigation; transforming growth factor beta; TGF-beta 3
TGF-beta 3 is a multifunctional cytokine involved in various physiological and pathological processes. It has the potential to mitigate radiation- and chemotherapy-induced toxicity in healthy tissue through cellular signaling pathways, cell cycle regulation, and anti-fibrotic effects.
Transforming growth factor-beta 3 (TGF-beta 3) is a ubiquitously expressed multifunctional cytokine involved in a range of physiological and pathological conditions, including embryogenesis, cell cycle regulation, immunoregulation, and fibrogenesis. The cytotoxic effects of ionizing radiation are employed in cancer radiotherapy, but its actions also influence cellular signaling pathways, including that of TGF-beta 3. Furthermore, the cell cycle regulating and anti-fibrotic effects of TGF-beta 3 have identified it as a potential mitigator of radiation- and chemotherapy-induced toxicity in healthy tissue. This review discusses the radiobiology of TGF-beta 3, its induction in tissue by ionizing radiation, and its potential radioprotective and anti-fibrotic effects..
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