期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/ijms24076265
关键词
mechanosensing mechanism; thick filament regulation; SRX; dual filament activation
Contraction in striated muscle is traditionally regulated by calcium-mediated structural changes in the thin filaments, but a new paradigm suggests that both the thin and thick filaments must be activated to generate force. There is growing evidence that thick filament activation plays a role in fine regulation of muscle and its impairment is associated with severe pathologies. This review focuses on the mechanosensing mechanism that activates inactive motors based on tension generated by active motors, highlighting the bi-directional feedback on muscle mechanics.
Contraction in striated muscle is classically described as regulated by calcium-mediated structural changes in the actin-containing thin filaments, which release the binding sites for the interaction with myosin motors to produce force. In this view, myosin motors, arranged in the thick filaments, are basically always ready to interact with the thin filaments, which ultimately regulate the contraction. However, a new dual-filament activation paradigm is emerging, where both filaments must be activated to generate force. Growing evidence from the literature shows that the thick filament activation has a role on the striated muscle fine regulation, and its impairment is associated with severe pathologies. This review is focused on the proposed mechanical feedback that activates the inactive motors depending on the level of tension generated by the active ones, the so-called mechanosensing mechanism. Since the main muscle function is to generate mechanical work, the implications on muscle mechanics will be highlighted, showing: (i) how non-mechanical modulation of the thick filament activation influences the contraction, (ii) how the contraction influences the activation of the thick filament and (iii) how muscle, through the mechanical modulation of the thick filament activation, can regulate its own mechanics. This description highlights the crucial role of the emerging bi-directional feedback on muscle mechanical performance.
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