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Interrelationship between COVID-19 and Coagulopathy: Pathophysiological and Clinical Evidence

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Medicine, General & Internal

Incidence of long COVID-19 in people with previous SARS-Cov2 infection: a systematic review and meta-analysis of 120,970 patients

Francesco Di Gennaro et al.

Summary: This study used a systematic review and meta-analysis of observational studies to determine the incidence of long COVID symptoms. The results showed that patients infected with SARS-CoV-2 may experience long-term COVID symptoms regardless of the severity of the acute illness. There were differences in the prevalence of long COVID symptoms among different genders, age groups, continents, and follow-up lengths.

INTERNAL AND EMERGENCY MEDICINE (2023)

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Article Cardiac & Cardiovascular Systems

Targeted genetic analysis unveils novel associations between ACE I/D and APO T158C polymorphisms with D-dimer levels in severe COVID-19 patients with pulmonary embolism

Giuseppe Fiorentino et al.

Summary: This study evaluated the genotypic distribution related to pulmonary embolism in COVID-19 patients. The findings showed significant associations between certain genotypes and thrombotic risk markers, which could serve as useful biomarkers for predicting clinical outcomes.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2023)

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Article Environmental Sciences

Circulating Peptidome Is Strongly Altered in COVID-19 Patients

Gianluca Baldanzi et al.

Summary: This study used an untargeted peptidomic approach to investigate the alterations of circulating peptides in COVID-19 patients. The results showed that peptide abundance is inversely correlated with disease severity and identified peptides related to inflammation, immune response, and coagulation processes. Additionally, changes in protein degradation patterns may be involved in the progression of the disease.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2023)

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Review Hematology

A Review of FXIa Inhibition as a Novel Target for Anticoagulation

Ioannis Koulas et al.

Summary: The limitations of vitamin K antagonists as chronic oral anticoagulant therapy have been replaced by direct factor IIa and factor Xa inhibitor oral anticoagulants. These new-generation oral anticoagulants offer similar efficacy, a better safety profile, no routine monitoring, and fewer drug-drug interactions compared to warfarin. However, there is still an increased risk of bleeding, especially in fragile patient populations or those requiring dual or triple antithrombotic therapy. Factor XIa inhibitors have shown potential as a safer alternative to existing anticoagulants, based on their ability to prevent thrombosis directly within the intrinsic pathway without affecting hemostatic mechanisms. Different types of factor XIa inhibitors are currently being studied in early phase clinical trials, and ongoing Phase III clinical trials aim to provide definitive answers regarding their safety and efficacy in preventing thromboembolic events in specific patient groups.

HAMOSTASEOLOGIE (2023)

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Article Cardiac & Cardiovascular Systems

Pneumothorax in hospitalized COVID-19 patients with severe respiratory failure: Risk factors and outcome

B. Ragnoli et al.

Summary: PNX is a rare complication in COVID-19 patients, and its clinical significance is still unclear. This study investigated the prevalence, risk predictors, and mortality of PNX in hospitalized COVID-19 patients with severe respiratory failure. The results showed that the prevalence of PNX was 8.1%, and the mortality rate was significantly higher in patients with PNX compared to those without PNX. Risk factors for PNX included a history of cognitive decline, non-invasive ventilation, and low P/F ratio.

RESPIRATORY MEDICINE (2023)

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Editorial Material Infectious Diseases

Rapid evaluation of the safety of COVID-19 vaccines: how well have we done? Comment

Elizabeth Miller

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Article Cardiac & Cardiovascular Systems

Pulmonary embolism in patients with COVID-19 pneumonia on adequate oral anticoagulation

Giuseppe Di Tano et al.

Summary: This report discusses five cases of patients on long-term oral anticoagulation therapy presenting with severe COVID-19 pneumonia associated with segmental acute pulmonary embolism. Despite adherence to therapy and adequate anticoagulant levels, the patients experienced thrombotic complications. Elevated levels of d-dimer, fibrinogen, and markers of inflammation were observed in all cases, supporting the hypothesis that severe viral infection may trigger local vascular damage leading to detected thrombi in the lungs.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2022)

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Review Critical Care Medicine

The Role of Histones and Heparin in Sepsis: A Review

Xiaojuan Zhang et al.

Summary: This review article summarizes the pathogenic roles of extracellular histones and the therapeutic roles of heparin in sepsis and septic shock management. While heparin has shown life-saving capabilities for septic patients, the potential interaction between heparin and extracellular histones has not been thoroughly investigated.

JOURNAL OF INTENSIVE CARE MEDICINE (2022)

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Article Environmental Sciences

Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Beatrice Ragnoli et al.

Summary: Sleep health is crucial for physical and mental well-being across animal species. Recent research has shown that sleep disturbances can have detrimental effects on immune health, increasing the risk for metabolic syndrome and immune suppression. Sleep disruption and circadian misalignment have been identified as new risk factors for dysregulated metabolic physiology. This review focuses on the relationship between sleep deprivation and immunity against viruses, with a specific interest in SARS-CoV-2 infection.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Review Medicine, General & Internal

The Role of Heparin in COVID-19: An Update after Two Years of Pandemics

Marco Mangiafico et al.

Summary: COVID-19 is associated with an increased risk of VTE and coagulopathy, with endothelial damage being a crucial mechanism. Heparin has multiple biological actions in the treatment of COVID-19.

JOURNAL OF CLINICAL MEDICINE (2022)

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Review Biochemistry & Molecular Biology

The Challenge of Long COVID-19 Management: From Disease Molecular Hallmarks to the Proposal of Exercise as Therapy

Raffaele Scurati et al.

Summary: Long COVID-19 is a novel syndrome that develops a few months after infection by SARS-CoV-2, characterized by clinical symptoms affecting various organs and tissues, and molecular mechanisms related to immune dysregulation, persistent inflammation, epigenetic modifications, and alterations in neurotrophin release. Exercise has the potential to improve the quality of life for long COVID-19 patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Immunology

Immunologic phenotype of patients with long-COVID syndrome of 1-year duration

Javier Garcia-Abellan et al.

Summary: Patients with 1-year duration long-COVID-19 syndrome exhibit a distinct immunologic phenotype that includes a poorer SARS-CoV-2 antibody response, low-degree chronic inflammation that tends to mitigate, and autoimmunity.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Hematology

Coagulation dysfunction in COVID-19: The interplay between inflammation, viral infection and the coagulation system

Maria Grazia Lazzaroni et al.

Summary: COVID-19 is a new pandemic caused by SARS-Cov2 infection, with inflammation and the innate immune system playing key roles in the most severe cases. Abnormalities in coagulation parameters and platelets count have been reported, suggesting a subgroup of patients with poor prognosis. The cytokine storm and virus-specific mechanisms may also contribute to adverse outcomes in COVID-19.

BLOOD REVIEWS (2021)

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Article Cardiac & Cardiovascular Systems

Antithrombotic therapy in patients with COVID-19? -Rationale and Evidence-

Cosmo Godino et al.

Summary: In patients with severe or critical COVID-19 manifestations, anticoagulant therapy may lead to better outcomes and serve as a possible protective mechanism against the prothrombotic state induced by SARS-CoV-2. The use of antiplatelet/anticoagulant therapy should be guided by clinical context and disease severity.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Anticoagulant treatment in COVID-19: a narrative review

Vincenzo Carfora et al.

Summary: The COVID-19 pandemic caused by SARS-CoV-2 often results in endothelial dysfunction, cytokine storm, and complement activation, leading to a pro-coagulative state and microvascular thrombi. The severity of thrombotic risk is directly linked to disease severity and prognosis, highlighting the importance of understanding the underlying mechanisms for effective treatment strategies.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

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Review Cell Biology

The Impact of COVID-19 Disease on Platelets and Coagulation

Geoffrey D. Wool et al.

Summary: COVID-19 infection can lead to a proinflammatory state and abnormalities in the coagulation mechanism, with patients often experiencing thrombosis. Elevated levels of D-dimer are positively correlated with mortality, and patients typically exhibit mild thrombocytopenia.

PATHOBIOLOGY (2021)

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Review Medicine, Research & Experimental

Exosomes in chronic respiratory diseases

Beatrice Purghe et al.

Summary: Exosomes are nano-sized vesicles released by cells, playing a central role in intercellular communication and potentially serving as biomarkers and therapeutic tools for chronic respiratory disorders. However, the exact relationship between different phenotypes and pathophysiological mechanisms of these diseases remains unclear, requiring further studies.

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Prognostic value of interleukin-18 and its association with other inflammatory markers and disease severity in COVID-19

Hasan Satis et al.

Summary: This study investigated the association of IL-18 with other inflammatory markers in COVID-19 patients, finding that serum IL-18 levels correlate with disease severity and higher levels are associated with worse outcomes.

CYTOKINE (2021)

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Neurological features and outcome in COVID-19: dementia can predict severe disease

Mehran Ghaffari et al.

Summary: Neurological symptoms are common in patients with COVID-19, including headaches and loss of smell. Dementia may increase the risk of severe COVID-19. Patients with neurological complications have a higher mortality rate and require more intensive care.

JOURNAL OF NEUROVIROLOGY (2021)

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Heparin in COVID-19 Patients Is Associated with Reduced In-Hospital Mortality: the Multicenter Italian CORIST Study *

Augusto Di Castelnuovo et al.

Summary: This study evaluated the impact of heparin administration on survival in a large cohort of Italian COVID-19 patients and found that in-hospital heparin treatment was associated with a lower mortality rate, especially in severely ill patients and those with strong coagulation activation. Further results from randomized clinical trials are needed to provide clear recommendations.

THROMBOSIS AND HAEMOSTASIS (2021)

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Article Medicine, General & Internal

ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role

Cecilia Calabrese et al.

Summary: Recent studies suggest a high risk of thromboembolism in patients with severe COVID-19 pneumonia, with a potential link to ACE gene polymorphisms. In this pilot study, researchers found a significant difference in ACE I/D polymorphisms between COVID-19 patients with and without pulmonary embolism, indicating a possible genetic susceptibility to thromboembolism in COVID-19.

FRONTIERS IN MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

Thrombosis and Coagulopathy in COVID-19

Juan Esteban Gomez-Mesa et al.

Summary: Since the outbreak of COVID-19 in Wuhan in December 2019, the virus has spread globally, leading to a pandemic declaration by the World Health Organization. Hospitalized patients with severe COVID-19 who have comorbidities and abnormal coagulation function are at higher risk of poor prognosis, while early anticoagulant treatment with low molecular weight heparin has been shown to significantly reduce mortality rates.

CURRENT PROBLEMS IN CARDIOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Renin-Angiotensin System: A Key Role in SARS-CoV-2-Induced COVID-19

George El-Arif et al.

Summary: COVID-19 caused by SARS-CoV-2 is a global pandemic, with RAS playing a crucial role in its pathogenesis. Host genetic polymorphisms and other related factors are important in influencing the severity and outcomes of the disease.

MOLECULES (2021)

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Article Cardiac & Cardiovascular Systems

Clinical outcome with different doses of low-molecular-weight heparin in patients hospitalized for COVID-19

Marco G. Mennuni et al.

Summary: In patients hospitalized for COVID-19, the use of prophylactic dose of enoxaparin appears to be associated with similar in-hospital overall mortality compared to higher doses, but significantly lower incidence of adverse events such as cardiovascular death, venous thromboembolism, new-onset ARDS, and mechanical intubation. These findings need to be confirmed in a randomized, controlled study.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2021)

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Review Medicine, General & Internal

The effect of coagulation factors in 2019 novel coronavirus patients A systematic review and meta-analysis

Guiling Xiang et al.

Summary: Analysis of 16 observational studies suggests a correlation between coagulation dysfunction in COVID-19 patients, disease severity, and mortality rates.

MEDICINE (2021)

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Article Medicine, General & Internal

Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study

Christopher T. Rentsch et al.

Summary: The study found that early initiation of prophylactic anticoagulation was associated with decreased risk of 30 day mortality among patients hospitalized with covid-19 in the United States, without increasing the risk of serious bleeding events.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Review Pharmacology & Pharmacy

Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence

Sayeeda Rahman et al.

Summary: The COVID-19 pandemic has caused a public health crisis, infecting millions and leading to numerous deaths. The virus spreads rapidly through direct person-to-person respiratory transmission. With no proven treatments, current clinical management focuses on symptom control, infection prevention, supportive care, and ICU support for severe cases. Developing an effective vaccine is a top priority, with some already approved for prevention.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2021)

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Review Hematology

Diagnosis and Management of Vaccine-Related Thrombosis following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH

Johannes Oldenburg et al.

HAMOSTASEOLOGIE (2021)

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Article Health Care Sciences & Services

Death from COVID-19: management of breathlessness: a retrospective multicentre study

Colette Reid et al.

Summary: This study assessed the management of breathlessness in patients dying from COVID-19. The results showed that less than a third of episodes of breathlessness were palliated with anticipatory medicines.

BMJ SUPPORTIVE & PALLIATIVE CARE (2021)

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Article Biology

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

Florence W. J. Chioh et al.

Summary: The impact of COVID-19 on vascular health of recovered patients is significant, with elevated levels of circulating endothelial cells indicating vascular injury. The presence of proinflammatory and activated T lymphocyte-associated cytokines suggests cytokine-driven endothelial dysfunction. Effector T cells were more frequent in COVID-19 convalescents, pointing to a possible cytotoxic effector cell targeting of activated endothelial cells.

ELIFE (2021)

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Article Medicine, General & Internal

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

Ewan C. Goligher et al.

Summary: In critically ill patients with Covid-19, initial therapeutic-dose anticoagulation did not result in improved survival rates or fewer days requiring cardiovascular or respiratory organ support compared to usual-care pharmacologic thromboprophylaxis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Pharmacology & Pharmacy

Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

Ekta Shirbhate et al.

Summary: ACE and ACE2 are linked to hypertension and cardiovascular disorders. COVID-19 exploits ACE2 receptors to enter human cells, leading to novel theories on their role in pathophysiology. Studies are raising questions about the significance of ACE proteins and genetic variants in response to SARS-CoV-2 infection.

PHARMACOLOGICAL REPORTS (2021)

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Review Cell Biology

Thrombosis in Covid-19 and non-Covid-19 pneumonia: role of platelets

Francesco Violi et al.

Summary: This review compares the type of vascular diseases complicating CAP and Covid-19, evaluates the different roles of platelets in both diseases, and discusses the potential usefulness of antiplatelet treatment in improving clinical outcomes. Until now, antiplatelet treatment has not been widely considered for Covid-19, but interventional trials are ongoing to explore this issue.

PLATELETS (2021)

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Comorbid Insomnia and Obstructive Sleep Apnea (COMISA): Current Concepts of Patient Management

Beatrice Ragnoli et al.

Summary: OSA and insomnia are the two most common sleep disorders among the general population, with a high prevalence of insomnia symptoms in OSA patients leading to the identification of the new disorder COMISA. Combined treatment of PAP and CBTi has shown better patient outcomes, and a patient-centered approach considering individual characteristics and treatment preferences is recommended for optimal clinical management of COMISA patients. Further research is needed to fully understand the impact of these therapies on outcomes for OSA patients with comorbidity.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Review Pharmacology & Pharmacy

The Impact of the Renin-Angiotensin-Aldosterone System on Inflammation, Coagulation, and Atherothrombotic Complications, and to Aggravated COVID-19

M. Ekholm et al.

Summary: Atherosclerosis is a disease caused by chronic inflammation and endothelial dysfunction, with up-regulated mediators of inflammation in affected individuals. Oxidative stress, imbalance between antioxidants and oxidants, leads to tissue damage. The renin-angiotensin-aldosterone system plays a vital role in vascular disease pathobiology, with angiotensin II causing hypertension and reactive oxygen species production. Blocking this system could potentially reduce inflammatory and thrombotic complications.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Medicine, General & Internal

Serum Metabolic Profile in Patients With Long-Covid (PASC) Syndrome: Clinical Implications

Evasio Pasini et al.

Summary: Patients with long-Covid syndrome exhibit abnormalities in blood markers related to coagulation, protein disarrangement, and inflammation, indicating ongoing metabolic alterations contributing to the persistence of PASC. Long-term elevated D-Dimer levels suggest potential risks for thromboembolic disease.

FRONTIERS IN MEDICINE (2021)

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Article Medicine, General & Internal

The Angiotensin Converting Enzyme Deletion/Deletion Genotype Is a Risk Factor for Severe COVID-19: Implication and Utility for Patients Admitted to Emergency Department

Anna Annunziata et al.

Summary: The study indicates a potential association between the high prevalence of ACE D/D polymorphism and severe COVID-19 in patients. Observing patients who test positive for the ACE D/D genotype without other risk factors for VTE could have a predictive role in identifying individuals more susceptible to developing severe COVID-19.

MEDICINA-LITHUANIA (2021)

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Review Primary Health Care

Rationales and uncertainties for aspirin use in COVID-19: a narrative review

Hazem A. Sayed Ahmed et al.

Summary: The review highlights the potential beneficial effects of aspirin in COVID-19 patients, particularly in reducing the risk of ICU admission and mechanical ventilation. However, further randomized controlled trials are needed to establish the causal relationship between aspirin and its protective roles in COVID-19.

FAMILY MEDICINE AND COMMUNITY HEALTH (2021)

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Review Hematology

COVID-19-associated coagulopathy and disseminated intravascular coagulation

Hidesaku Asakura et al.

Summary: The pathology of COVID-19 is exacerbated by thrombosis, DIC, and cytokine storms. D-dimer levels are commonly elevated in COVID-19, but relying solely on this marker has limitations. Treatment should be individualized based on disease severity and stage, with potential for combination therapy using heparin and nafamostat in the future. Further research is needed on fibrinolytic therapy and adsorption therapy.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2021)

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Ethnic Prevalence of Angiotensin-Converting Enzyme Deletion (D) Polymorphism and COVID-19 Risk: Rationale for Use of Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers

Rangaprasad Sarangarajan et al.

Summary: The study suggests a correlation between ACE insertion/deletion polymorphism and COVID-19 infections and comorbidities, with higher frequency of ACE D allele in European, Asian, African, and American populations. ACE DD polymorphism may lead to inflammation, organ damage, and increased risk of COVID-19 infection.

JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES (2021)

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Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

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Dominic Wichmann et al.

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Changes in blood coagulation in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis

Xiong Mi et al.

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Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study

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Incidence of venous thromboembolism in hospitalized patients with COVID-19

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ISTH interim guidance on recognition and management of coagulopathy in COVID-19

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Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

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Letter Immunology

ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia

Felice Rivellese et al.

AUTOIMMUNITY REVIEWS (2020)

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Review Immunology

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

Bingwen Liu et al.

JOURNAL OF AUTOIMMUNITY (2020)

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Review Medicine, General & Internal

COVID-19 and Obesity: Dangerous Liaisons

Grazia Caci et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Medicine, Research & Experimental

Longitudinal COVID-19 profiling associates IL-1RA and IL-10 with disease severity and RANTES with mild disease

Yan Zhao et al.

JCI INSIGHT (2020)

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Article Virology

Coagulation disorders in coronavirus infected patients: COVID-19, SARS- CoV-1, MERS-CoV and lessons from the past

Dimitrios Giannis et al.

JOURNAL OF CLINICAL VIROLOGY (2020)

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Letter Medicine, General & Internal

Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 (COVID-19)

Julien Nahum et al.

JAMA NETWORK OPEN (2020)

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Review Infectious Diseases

The pathogenesis and treatment of the 'Cytokine Storm' in COVID-19

Qing Ye et al.

JOURNAL OF INFECTION (2020)

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Review Cardiac & Cardiovascular Systems

Potential Therapeutic Roles for Direct Factor Xa Inhibitors in Coronavirus Infections

Rami A. Al-Horani

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS (2020)

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Review Hematology

Coagulopathy in COVID-19

Toshiaki Iba et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Review Cardiac & Cardiovascular Systems

Venous thromboembolism in critically ill COVID-19 patients receiving prophylactic or therapeutic anticoagulation: a systematic review and meta-analysis

Syed Shahzad Hasan et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

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Article Oncology

Hematological features of persons with COVID-19

Qiubai Li et al.

LEUKEMIA (2020)

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Article Medicine, Research & Experimental

The Potential of Low Molecular Weight Heparin to Mitigate Cytokine Storm in Severe COVID-19 Patients: A Retrospective Cohort Study

Chen Shi et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2020)

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Review Critical Care Medicine

POTENTIAL IMMUNOTHERAPEUTIC TARGETS FOR HYPOXIA DUE TO COVI-FLU

Yan Leyfman et al.

SHOCK (2020)

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Article Hematology

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

F. A. Klok et al.

THROMBOSIS RESEARCH (2020)

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Article Hematology

Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy

Corrado Lodigiani et al.

THROMBOSIS RESEARCH (2020)

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Review Cell Biology

The coagulopathy, endotheliopathy, and vasculitis of COVID-19

Toshiaki Iba et al.

INFLAMMATION RESEARCH (2020)

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Article Multidisciplinary Sciences

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

Jinsung Yang et al.

NATURE COMMUNICATIONS (2020)

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Article Immunology

Anti-Phospholipid Antibodies in COVID-19 Are Different From Those Detectable in the Anti-Phospholipid Syndrome

Maria Orietta Borghi et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Letter Hematology

SARS-CoV-2 Transmission and Outcome in Neuro-rehabilitation Patients Hospitalized at Neuroscience Hospital in Italy

Francesco Di Gennaro et al.

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES (2020)

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Article Cell Biology

Coagulopathy in patients with COVID-19: A systematic review and meta-analysis

Xiaolin Zhang et al.

Aging-US (2020)

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Article Pharmacology & Pharmacy

Treatment for COVID-19: An overview

Cristina Stasi et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Genetics & Heredity

Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome

Juan Gomez et al.

GENE (2020)

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Review Respiratory System

ACE2: The Major Cell Entry Receptor for SARS-CoV-2

Filippo Scialo et al.

LUNG (2020)

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Review Hematology

COVID-19 and Hypercoagulability: A Review

Asim Kichloo et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2020)

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Article Critical Care Medicine

Thrombotic and haemorrhagic complications in critically ill patients with COVID-19: a multicentre observational study

Akshay Shah et al.

CRITICAL CARE (2020)

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Review Rheumatology

Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia

Dennis McGonagle et al.

LANCET RHEUMATOLOGY (2020)

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Letter Critical Care Medicine

Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study

Megan Fraisse et al.

CRITICAL CARE (2020)

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Article Hematology

The contact activation system as a potential therapeutic target in patients with COVID-19

Joseph J. Shatzel et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2020)

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Review Critical Care Medicine

Blocking IL-1 to prevent respiratory failure in COVID-19

Frank L. van de Veerdonk et al.

CRITICAL CARE (2020)

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Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Editorial Material Cardiac & Cardiovascular Systems

Acute pulmonary embolism and COVID-19 pneumonia: a random association?

Gian Battista Danzi et al.

EUROPEAN HEART JOURNAL (2020)

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Review Hematology

The stimulation of thrombosis by hypoxia

Neha Gupta et al.

THROMBOSIS RESEARCH (2019)

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Article Peripheral Vascular Disease

Association of ACE2 genetic polymorphisms with hypertension-related target organ damages in south Xinjiang

Yi Luo et al.

HYPERTENSION RESEARCH (2019)

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Article Surgery

Empirical systemic anticoagulation is associated with decreased venous thromboembolism in critically ill influenza A H1N1 acute respiratory distress syndrome patients

Andrea T. Obi et al.

JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS (2019)

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Article Hematology

Inhibition of contact-mediated activation of factor XI protects baboons against S aureus-induced organ damage and death

Robert Silasi et al.

BLOOD ADVANCES (2019)

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Review Pediatrics

The Role of Inflammation in Venous Thromboembolism

Brian R. Branchford et al.

FRONTIERS IN PEDIATRICS (2018)

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Review Hematology

Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies

Chrysoula Papageorgiou et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2018)

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Review Hematology

Human blood platelets and viruses: defense mechanism and role in the removal of viral pathogens

Masresha Seyoum et al.

THROMBOSIS JOURNAL (2018)

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Review Hematology

Coagulation and sepsis

Marcel Levi et al.

THROMBOSIS RESEARCH (2017)

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Review Hematology

The potential role of endothelial dysfunction and platelet activation in the development of thrombotic risk in COPD patients

Mario Malerba et al.

EXPERT REVIEW OF HEMATOLOGY (2017)

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Article Pharmacology & Pharmacy

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells

Silvia Ghezzi et al.

ANTIVIRAL RESEARCH (2017)

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Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Review Chemistry, Medicinal

Heparin: Past, Present, and Future

Eziafa I. Oduah et al.

PHARMACEUTICALS (2016)

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Review Immunology

Human platelets and their capacity of binding viruses: meaning and challenges?

Adrien Chabert et al.

BMC IMMUNOLOGY (2015)

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Article Medicine, General & Internal

Thromboembolic events in patients with severe pandemic influenza A/H1N1

Lone Solling Avnon et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2015)

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Review Immunology

Platelets and infection - an emerging role of platelets in viral infection

Alice Assinger

FRONTIERS IN IMMUNOLOGY (2014)

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Article Medicine, General & Internal

Effect of acute exacerbations on circulating endothelial, clotting and fibrinolytic markers in COPD patients

Riccardo Polosa et al.

INTERNAL AND EMERGENCY MEDICINE (2013)

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Article Medicine, Research & Experimental

Type 2 alveolar cells are stem cells in adult lung

Christina E. Barkauskas et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Article Microbiology

Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

Lisa E. Gralinski et al.

MBIO (2013)

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Review Hematology

Platelet activation as a novel mechanism of atherothrombotic risk in chronic obstructive pulmonary disease

Mario Malerba et al.

EXPERT REVIEW OF HEMATOLOGY (2013)

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Article Peripheral Vascular Disease

Association of ACE2 Genetic Variants With Blood Pressure, Left Ventricular Mass, and Cardiac Function in Caucasians With Type 2 Diabetes

Sheila K. Patel et al.

AMERICAN JOURNAL OF HYPERTENSION (2012)

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Review Cardiac & Cardiovascular Systems

Three key proteases - angiotensin-l-converting enzyme (ACE), ACE2 and renin - within and beyond the renin-angiotensin system

Cuie Guang et al.

ARCHIVES OF CARDIOVASCULAR DISEASES (2012)

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Article Hematology

Neutrophil Extracellular Trap (NET) Impact on Deep Vein ThrombosisTobias

Tobias A. Fuchs et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

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Article Critical Care Medicine

Prevention of VTE in Nonsurgical Patients Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Susan R. Kahn et al.

CHEST (2012)

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Review Virology

Review: Viral infections and mechanisms of thrombosis and bleeding

M. Goeijenbier et al.

JOURNAL OF MEDICAL VIROLOGY (2012)

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Review Immunology

Systemic versus localized coagulation activation contributing to organ failure in critically ill patients

Marcel Levi et al.

SEMINARS IN IMMUNOPATHOLOGY (2012)

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Article Hematology

Infection and Inflammation as Risk Factors for Thrombosis and Atherosclerosis

Marcel Levi et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2012)

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Article Urology & Nephrology

The Presence of PAI-1 4G/5G and ACE DD Genotypes Increases the Risk of Early-Stage AVF Thrombosis in Hemodialysis Patients

Yahya Gungor et al.

RENAL FAILURE (2011)

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Article Biochemistry & Molecular Biology

Extracellular histones are major mediators of death in sepsis

Jun Xu et al.

NATURE MEDICINE (2009)

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Article Medicine, General & Internal

Association between cytomegalovirus infection and venous thromboembolism

Zvi G. Fridlender et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2007)

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Letter Hematology

Analysis of thrombotic factors in severe acute respiratory syndrome (SARS) patients

Ya Ping Wu et al.

THROMBOSIS AND HAEMOSTASIS (2006)

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Article Hematology

Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation

A Reheman et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)

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Review Hematology

Thrombocytopenia in patients with severe acute respiratory syndrome (review)

M Yang et al.

HEMATOLOGY (2005)

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Review Pharmacology & Pharmacy

The pulmonary renin-angiotensin system

RP Marshall

CURRENT PHARMACEUTICAL DESIGN (2003)

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Article Cardiac & Cardiovascular Systems

ACE/DD genotype is associated with hemostasis balance disturbances reflecting hypercoagulability and endothelial dysfunction in patients with untreated hypertension

TK Makris et al.

AMERICAN HEART JOURNAL (2000)

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Article Hematology

Platelets release thrombopoietin (Tpo) upon activation: another regulatory loop in thrombocytopoiesis?

CC Folman et al.

THROMBOSIS AND HAEMOSTASIS (2000)

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