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Extracellular Matrix Regulation in Physiology and in Brain Disease

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Summary: In this review, the authors summarize recent studies that have expanded our understanding of microglia's role in brain wiring beyond synapse pruning. They highlight the bidirectional communication between microglia and neurons, regulated by neuronal activity and extracellular matrix remodeling, which influences neuronal numbers and connectivity. The authors also propose an integrative view of microglia as active elements in neural circuits.

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Extracellular matrix and synapse formation

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Summary: The extracellular matrix (ECM) is a complex molecular network that is distributed throughout different tissues and the neuronal system. It plays crucial roles in neuronal maturation, signal transduction, and synapse formation. Various ECM components interact or bind to specific receptors to regulate neurogenesis, neuronal migration, axonal growth, and synaptic stability and plasticity.

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Extracellular matrix and synapse formation

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Summary: The extracellular matrix (ECM) is a complex molecular network that influences various processes in the neuronal system, including neurogenesis, neuron migration, axonal growth, synapse formation, and synaptic plasticity. ECM components play crucial roles in these processes and their abnormalities can lead to neurodevelopmental disorders.

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Microglia-mediated degradation of perineuronal nets promotes pain

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The Synaptic Extracellular Matrix: Long-Lived, Stable, and Still Remarkably Dynamic

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Reorganization of the Brain Extracellular Matrix in Hippocampal Sclerosis

Barbara Sitas et al.

Summary: This study evaluated the ECM profile of HS1 in drug-resistant MTLE patients and found changes in PNNs, ECM proteins, and glycosylation patterns associated with the condition. These findings suggest that ECM molecules and their modulators could be potential targets for developing new therapeutic approaches to drug-resistant epilepsy.

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Mutual antagonism between aryl hydrocarbon receptor and hypoxia-inducible factor-1α (AhR/HIF-1α) signaling: Impact on the aging process

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The Role of Extracellular Matrix in Human Neurodegenerative Diseases

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A glial perspective on the extracellular matrix and perineuronal net remodeling in the central nervous system

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Summary: The extracellular matrix (ECM) and perineuronal nets (PNNs) serve as structural scaffolds in the central nervous system (CNS) with diverse functions, including neurogenesis, cell migration and differentiation, axonal growth, and synaptic stability. Glial cells play a key role in regulating the malleability of ECM and PNNs, impacting their functions in both health and diseases.

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Altered Extracellular Matrix as an Alternative Risk Factor for Epileptogenicity in Brain Tumors

Jody M. de Jong et al.

Summary: Seizures are a common symptom of brain tumors, especially in paediatric-type tumors. The extracellular matrix plays a role in epileptogenesis and tumorigenesis. Understanding the epileptogenic properties of brain tumors is crucial for improving health outcomes and developing novel therapies.

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A guide to the composition and functions of the extracellular matrix

Nikos K. Karamanos et al.

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Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease

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Microglia as hackers of the matrix: sculpting synapses and the extracellular space

Joshua D. Crapser et al.

Summary: Microglia play a crucial role in shaping the synaptic environment in the brain, including modulating the perisynaptic matrix and perineuronal nets (PNNs). Alterations in the extracellular matrix (ECM) surrounding synapses may have implications for synapse dynamics, highlighting the interconnected relationship between microglia, synapses, and the ECM. Further research is needed to understand the mechanisms by which microglial regulation of the ECM impacts normal brain homeostasis and diseases.

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Perineuronal Net Dynamics in the Pathophysiology of Epilepsy

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Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R+/- mouse model of ALSP, which can be rescued via CSF1R inhibitors

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Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice

Luisa Strackeljan et al.

Summary: Microglia play a role in regulating the remodeling of perineuronal nets (PNNs) and perisynaptic extracellular matrix (ECM), as well as the fine structure of PNNs and excitatory terminals in the hippocampus.

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Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons in vitro

David Wegrzyn et al.

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Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

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Matrix metalloproteinase-9 regulates TNF-α and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis

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EXPERIMENTAL NEUROLOGY (2007)

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Review Cell Biology

Matrix metalloproteinases, their production by monocytes and macrophages and their potential role in HIV-related diseases

Nicole L. Webster et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2006)

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Article Immunology

Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1β (IL-1β) in astrocyte cultures

Wandong Zhang et al.

JOURNAL OF NEUROIMMUNOLOGY (2006)

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Article Neurosciences

Focal cerebral ischemia induces changes in both MMP-13 and aggrecan around individual neurons

S Nagel et al.

BRAIN RESEARCH (2005)

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Article Biochemistry & Molecular Biology

Matrikines in the regulation of extracellular matrix degradation

F Maquart et al.

BIOCHIMIE (2005)

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Review Oncology

An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity - Implication in tumor invasion

FX Maquart et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2004)

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Article Clinical Neurology

Sleep disorders in multiple system atrophy: a correlative video-polysomnographic study

R Vetrugno et al.

SLEEP MEDICINE (2004)

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Review Neurosciences

Extracellular matrix molecules and synaptic plasticity

A Dityatev et al.

NATURE REVIEWS NEUROSCIENCE (2003)

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Article Neurosciences

A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration

K Watase et al.

NEURON (2002)

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Review Physiology

Proteoglycans in the developing brain: New conceptual insights for old proteins

CE Bandtlow et al.

PHYSIOLOGICAL REVIEWS (2000)

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