Endotheliopathy in Acute COVID-19 and Long COVID

The pulmonary endothelium is a highly regulated organ that performs a wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play a direct role in sepsis and acute respiratory distress syndrome, its role in COVID-19 has also been extensively investigated. Indeed, apart from the COVID-19-associated coagulopathy biomarkers, new biomarkers were recognised early during the pandemic, including markers of endothelial cell activation or injury. We systematically searched the literature up to 10 March 2023 for studies examining the association between acute and long COVID-19 severity and outcomes and endothelial biomarkers.

Automated summary

The pulmonary endothelium performs various functions and plays a role in sepsis, acute respiratory distress syndrome, and COVID-19. Studies have examined the association between COVID-19 severity and outcomes and endothelial biomarkers, including markers of endothelial activation or injury. New biomarkers have been identified during the pandemic in addition to coagulopathy markers.