4.7 Review

A Critical View over the Newest Antidiabetic Molecules in Light of Efficacy-A Systematic Review and Meta-Analysis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

An update on peptide-based therapies for type 2 diabetes and obesity

Clifford J. Bailey et al.

Summary: Long-acting analogues of GLP-1 and GLP-1R/GIP-R dual agonists have shown high efficacy in lowering glucose levels and promoting weight loss. These peptide-based therapies provide a promising approach for treating T2D and obesity. Semaglutide, an GLP-1R agonist, has shown particularly high efficacy and is available in oral and injectable formulations. Other pharmacological approaches, such as monoclonal antibodies and agonists targeting different receptors, are also being explored for chronic weight management. However, the high demand for GLP-1R agonists as anti-obesity agents has caused a shortage, leading to their prioritized use in T2D therapy.

PEPTIDES (2023)

Article Environmental Sciences

Multiple Medication Adherence and Related Outcomes in Community-Dwelling Older People on Chronic Polypharmacy: A Retrospective Cohort Study on Administrative Claims Data

Carlotta Franchi et al.

Summary: This study assessed the multiple medication adherence to common drug classes prescribed to older people and its association with clinical outcomes. The findings showed that higher adherence was associated with better clinical outcomes, including improved survival and lower nursing home admissions.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

Review Medicine, General & Internal

The Impact of Novel Anti-Diabetic Medications on CV Outcomes: A New Therapeutic Horizon for Diabetic and Non-Diabetic Cardiac Patients

Israel Mazin et al.

Summary: Over the past two decades, the number of patients diagnosed with diabetes mellitus has doubled. Despite advancements in cardiovascular disease treatment, patients with diabetes are still at a higher risk of dying from cardiovascular causes compared to non-diabetic individuals. However, recent breakthroughs in anti-diabetic therapies have shown cardiovascular benefits and reduced mortality rates.

JOURNAL OF CLINICAL MEDICINE (2022)

Review Cardiac & Cardiovascular Systems

Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction

Michael A. Nauck et al.

Summary: Tirzepatide, the first dual GIP/GLP-1 receptor co-agonist approved for the treatment of type 2 diabetes, has shown to be effective in reducing HbA(1c) and body weight, and has good cardiovascular safety. However, there are still questions regarding its mechanism of action.

CARDIOVASCULAR DIABETOLOGY (2022)

Article Cell Biology

LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept

Tamer Coskun et al.

Summary: With the increasing prevalence of obesity, there is a need for new therapies to improve body weight management and metabolic health. The novel triple agonist peptide LY3437943 shows promising results in reducing body weight and improving glycemic control in obese mice, making it a potential treatment for obesity.

CELL METABOLISM (2022)

Article Medicine, General & Internal

LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial

Shweta Urva et al.

Summary: LY3437943, a multi-receptor agonist for the treatment of type 2 diabetes and obesity, demonstrated acceptable safety, suitable pharmacokinetics for once-weekly dosing, and significant improvements in glucose and bodyweight outcomes in this study.

LANCET (2022)

Review Medicine, General & Internal

Prevalence of polypharmacy and associated adverse health outcomes in adult patients with chronic kidney disease: protocol for a systematic review and meta-analysis

Ikechi G. Okpechi et al.

Summary: This study aims to evaluate the prevalence of polypharmacy among adult patients with chronic kidney disease (CKD) and its potential association with adverse health outcomes. Utilizing observational data, the study will conduct meta-analysis to summarize the findings, shedding light on the potential risks of polypharmacy among CKD patients.

SYSTEMATIC REVIEWS (2021)

Article Endocrinology & Metabolism

Phase III, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of teneligliptin monotherapy in Chinese patients with type 2 diabetes mellitus inadequately controlled with diet and exercise

Linong Ji et al.

Summary: The study found that teneligliptin was effective in reducing glycosylated hemoglobin and fasting blood glucose levels in Chinese patients with type 2 diabetes who were inadequately controlled with diet and exercise. Additionally, the drug was well tolerated with no significant difference in adverse events compared to the placebo group.

JOURNAL OF DIABETES INVESTIGATION (2021)

Article Cardiac & Cardiovascular Systems

Effect of Empagliflozin on Cardiovascular and Renal Outcomes in Patients With Heart Failure by Baseline Diabetes Status Results From the EMPEROR-Reduced Trial

Stefan D. Anker et al.

Summary: In patients with chronic heart failure with reduced ejection fraction, empagliflozin significantly improved cardiovascular and renal outcomes, regardless of baseline diabetes status, and across the continuum of HbA1c.

CIRCULATION (2021)

Article Medicine, General & Internal

Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease

Deepak L. Bhatt et al.

Summary: The trial involving 10,584 patients with diabetes and chronic kidney disease showed that sotagliflozin resulted in fewer deaths from cardiovascular causes, hospitalizations for heart failure, and urgent visits for heart failure compared to placebo. However, there were adverse events such as diarrhea, mycotic infections, and diabetic ketoacidosis associated with sotagliflozin.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure

Deepak L. Bhatt et al.

Summary: In patients with diabetes and recent worsening heart failure, treatment with sotagliflozin significantly reduced the total number of deaths from cardiovascular causes and hospitalizations and urgent visits for heart failure compared to placebo, regardless of the timing of administration.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Pharmacology & Pharmacy

Drug Induced Liver Injury in Geriatric Patients Detected by a Two-Hospital Prospective Pharmacovigilance Program: A Comprehensive Analysis Using the Roussel Uclaf Causality Assessment Method

Laura Pedraza et al.

Summary: A prospective evaluation of drug-induced liver injury (DILI) in elderly patients over 65 years old showed a higher-than-expected incidence rate, with risk factors including polypharmacy, specific drug use, and patient age.

FRONTIERS IN PHARMACOLOGY (2021)

Review Medicine, General & Internal

The Effect of a Comprehensive, Interdisciplinary Medication Review on Quality of Life and Medication Use in Community Dwelling Older People with Polypharmacy

Donna Bosch-Lenders et al.

Summary: A comprehensive medication review conducted at patients' homes can prevent a decrease in mental health and reduce the number of prescribed medications among patients aged 60 years and older with polypharmacy.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Pharmacology & Pharmacy

Specific features of rational pharmacotherapy in elderly patients

Dmitriy Ermakov et al.

Summary: The study examined trends in prescribing medications for elderly patients and their compliance with rational pharmacotherapy principles. Factors affecting adherence to treatment were also identified. The results showed a high prevalence of polypharmacy among elderly patients, with most patients not adhering to the prescribed drug regimen due to complexity, high costs, lack of disease knowledge, and understanding of drug necessity and efficacy.

EUROPEAN JOURNAL OF HOSPITAL PHARMACY (2021)

Article Geriatrics & Gerontology

Persistent polypharmacy and fall injury risk: the Health, Aging and Body Composition Study

Lingshu Xue et al.

Summary: This study examined the association between persistent polypharmacy and treated fall injuries in community-dwelling older adults, concluding that persistent polypharmacy, especially in combination with medications that increase fall risk, was linked to an increased risk of fall injuries in both inpatient and outpatient settings.

BMC GERIATRICS (2021)

Review Pharmacology & Pharmacy

Polypharmacy Management in the Older Adults: A Scoping Review of Available Interventions

M. Kurczewska-Michalak et al.

Summary: Various approaches to polypharmacy management are recommended in current literature, differing in complexity, applicability, and usability, with no identifiable gold standard. In practice, explicit criteria-based drug reviews appear to be advisable.

FRONTIERS IN PHARMACOLOGY (2021)

Article Endocrinology & Metabolism

Improved postprandial glucose metabolism in type 2 diabetes by the dual glucagon-like peptide-1/glucagon receptor agonist SAR425899 in comparison with liraglutide

Michele Schiavon et al.

Summary: In overweight to obese subjects with T2D, both SAR425899 and liraglutide improved postprandial glucose control, with SAR425899 showing a significantly higher enhancement in beta-cell function.

DIABETES OBESITY & METABOLISM (2021)

Article Medicine, General & Internal

Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2.4 mg for weight management: a randomised, controlled, phase 1b trial

Lone B. Enebo et al.

Summary: The study aimed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the combination of Cagrilintide and Semaglutide for weight management. Results showed that concomitant treatment with Cagrilintide and Semaglutide was well tolerated with an acceptable safety profile. Larger and longer trials are needed to fully assess the efficacy and safety of this treatment combination.

LANCET (2021)

Article Endocrinology & Metabolism

Effects of Cotadutide on Metabolic and Hepatic Parameters in Adults With Overweight or Obesity and Type 2 Diabetes: A 54-Week Randomized Phase 2b Study

Rajaa Nahra et al.

Summary: Cotadutide treatment for 54 weeks improved glycemic control and weight loss in participants with overweight/obesity and type 2 diabetes. Ad hoc analyses demonstrated improvements in hepatic parameters and support further evaluation of cotadutide in NASH.

DIABETES CARE (2021)

Review Pharmacology & Pharmacy

Emerging glucagon-like peptide 1 receptor agonists for the treatment of obesity

Mathies M. Jepsen et al.

Summary: Obesity is a serious public health threat, with over 1.1 billion individuals projected to have obesity in 2030 if current trends continue. There is a strong interest in developing obesity treatments based on GLP-1 agonism, with many novel compounds in clinical development aiming to target the GLP-1 receptor or other hormonal systems involved in energy balance and metabolism. Semaglutide is the most advanced compound in clinical development and may become a benchmark for novel anti-obesity compounds utilizing GLP-1 receptor agonism.

EXPERT OPINION ON EMERGING DRUGS (2021)

Article Medicine, General & Internal

Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

Julio Rosenstock et al.

Summary: Tirzepatide demonstrated significant improvements in glycemic control and body weight without increasing the risk of hypoglycemia. The safety profile was consistent with GLP-1 receptor agonists, suggesting a potential monotherapy use for the treatment of type 2 diabetes.

LANCET (2021)

Article Medicine, General & Internal

Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial

Bernhard Ludvik et al.

Summary: The study aimed to compare the efficacy and safety of tirzepatide versus titrated insulin degludec in the treatment of type 2 diabetes. The results showed that tirzepatide had significant advantages in reducing HbA(1c) and bodyweight, and decreased the risk of hypoglycemia.

LANCET (2021)

Article Biochemistry & Molecular Biology

Danuglipron (PF-06882961) in type 2 diabetes: a randomized, placebo-controlled, multiple ascending-dose phase 1 trial

Aditi R. Saxena et al.

Summary: In this study, danuglipron showed good tolerability in T2D patients, with a safety profile consistent with the mechanism of action of GLP-1R agonism.

NATURE MEDICINE (2021)

Article Medicine, General & Internal

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes

Juan P. Frias et al.

Summary: The study showed that Tirzepatide was both noninferior and superior to Semaglutide in terms of the mean change in glycated hemoglobin levels for patients with type 2 diabetes over 40 weeks. Additionally, reductions in body weight were greater with Tirzepatide compared to Semaglutide, with similar rates of gastrointestinal adverse events reported in both groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Polypharmacy is associated with malnutrition and activities of daily living disability among daycare facility users A cross-sectional study

Tomiyo Nakamura et al.

Summary: Polypharmacy may lead to malnutrition and ADL disability in older individuals, with certain drugs such as proton pump inhibitors, anticonstipation drugs, and antihypertensive drugs being associated with malnutrition, while proton pump inhibitors, anticonstipation drugs, antidyslipidemia drugs, and antidiabetic drugs being associated with ADL disability. Anorexia was related to the loss of pleasure of eating, which in turn was related to psychological stress. Further multicenter prospective studies are needed to confirm these findings.

MEDICINE (2021)

Review Pharmacology & Pharmacy

Addressing the Challenge of Polypharmacy

Alpana Mair et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 60 (2020)

Review Medicine, General & Internal

Impact of Glucose-Lowering Medications on Cardiovascular and Metabolic Risk in Type 2 Diabetes

Angelo Maria Patti et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Medicine, General & Internal

Population ageing and mortality during 1990-2017: A global decomposition analysis

Xunjie Cheng et al.

PLOS MEDICINE (2020)

Article Medicine, General & Internal

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure

Milton Packer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Dapagliflozin in Patients with Chronic Kidney Disease

Hiddo J. L. Heerspink et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

George L. Bakris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes

Christopher P. Cannon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Pharmacology & Pharmacy

Novel Antidiabetic Agents: Cardiovascular and Safety Outcomes

Gerasimos Siasos et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

Article Cardiac & Cardiovascular Systems

Polypharmacy Is Associated With Accelerated Deterioration of Renal Function in Cardiovascular Outpatients

Jun-ichi Sakamoto et al.

CARDIOLOGY RESEARCH (2020)

Article Health Care Sciences & Services

Associations Between Polypharmacy, Symptom Burden, and Quality of Life in Patients with Advanced, Life-Limiting Illness

Yael Schenker et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2019)

Review Endocrinology & Metabolism

Dipeptidyl peptidase-4 inhibitors and cardiovascular and renal disease in type 2 diabetes: What have we learned from the CARMELINA trial?

Nordin M. J. Hanssen et al.

DIABETES & VASCULAR DISEASE RESEARCH (2019)

Review Endocrinology & Metabolism

SGLT2 Inhibitors: Cardiovascular Benefits Beyond HbA1c-Translating Evidence into Practice

Amar Ali et al.

DIABETES THERAPY (2019)

Article Medicine, General & Internal

Polypharmacy in Type 2 Diabetes Mellitus: Insights from an Internal Medicine Department

Elena-Codruta Dobrica et al.

MEDICINA-LITHUANIA (2019)

Review Environmental Sciences

SGLT2 Inhibitors: A Review of Their Antidiabetic and Cardioprotective Effects

Anastasios Tentolouris et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2019)

Article Endocrinology & Metabolism

Implications of the recent CVOTs in type 2 diabetes: The right place for DPP-IV inhibitors today

Zachary T. Bloomgarden

DIABETES RESEARCH AND CLINICAL PRACTICE (2019)

Article Medicine, General & Internal

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes

S. D. Wiviott et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Pharmacology & Pharmacy

A comparative safety review between GLP-1 receptor agonists and SGLT2 inhibitors for diabetes treatment

Agostino Consoli et al.

EXPERT OPINION ON DRUG SAFETY (2018)

Article Pharmacology & Pharmacy

Polypharmacy in Assisted Living and Impact on Clinical Outcomes

Barbara Resnick et al.

CONSULTANT PHARMACIST (2018)

Review Geriatrics & Gerontology

What is polypharmacy? A systematic review of definitions

Nashwa Masnoon et al.

BMC GERIATRICS (2017)

Editorial Material Medicine, General & Internal

The epidemiology of polypharmacy

Rupert A. Payne

CLINICAL MEDICINE (2016)

Article Geriatrics & Gerontology

Antidiabetic Medications and Polypharmacy

Emily P. Peron et al.

CLINICS IN GERIATRIC MEDICINE (2015)

Article Medicine, General & Internal

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

Jennifer B. Green et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Editorial Material Biochemistry & Molecular Biology

Living too long

Guy C. Brown

EMBO REPORTS (2015)

Article Medicine, General & Internal

Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement

David Moher et al.

SYSTEMATIC REVIEWS (2015)

Article Urology & Nephrology

Safety and efficacy of teneligliptin: a novel DPP-4 inhibitor for hemodialysis patients with type 2 diabetes

Hideo Otsuki et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2014)

Article Public, Environmental & Occupational Health

Multimorbidity in Older Adults

Marcel E. Salive

EPIDEMIOLOGIC REVIEWS (2013)

Article Medicine, General & Internal

Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus

Benjamin M. Scirica et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)