☆ 4.7 Article

Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression

Kazuhiro Nishiyama et al.

Summary: This study identified a mechanism called redox-dependent alternative internalization (REDAI) that promotes the internalization and degradation of the purinergic P2Y(6) receptor (P2Y(6)R). The researchers found that both synthetic and natural compounds containing electrophilic isothiocyanate groups can modify P2Y(6)R and facilitate its internalization and degradation. This mechanism, mediated by cysteine modification, may also play a role in the internalization of other G protein-coupled receptors (GPCRs) and potentially limit the progression of colitis.

SCIENCE SIGNALING (2022)

添加到收藏夹

Article Oncology

The Role of Purinergic P2X7 Receptor in Inflammation and Cancer: Novel Molecular Insights and Clinical Applications

John Charles Rotondo et al.

Summary: This review summarizes the function, activation, and ligands of the purinergic P2X7 receptor (P2X7R), as well as its role in inflammation and cancer. The activation of P2X7R has been found to have both pro- and anti-tumor effects. The article also describes the current therapeutic approaches and clinical trials of P2X7R modulators.

CANCERS (2022)

添加到收藏夹

Article Dermatology

P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by Regulating the YAP and β-Catenin Signaling Pathways

Peng Xu et al.

Summary: P2RY6 plays a promoting role in skin tumorigenesis by modulating the Hippo/YAP and Wnt/β-catenin signaling pathways, affecting keratinocyte proliferation and inflammatory reactions.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

添加到收藏夹

Article Immunology

Inhibition of P2Y6 receptor expression in Kupffer cells alleviates alcoholic steatohepatitis in mice

Fei Yuan et al.

Summary: In this study, the role of P2Y6 in alcoholic steatohepatitis was investigated. P2Y6 levels were found to be elevated in Kupffer cells in mice with alcoholic steatohepatitis and ethanol-induced RAW264.7 cells. Inhibition of P2Y6 showed improvement in steatosis and inflammation, while P2Y6 activation had contrasting results. Furthermore, P2Y6 was found to regulate the activation of the p38 MAPK signaling pathway through mediating calcium influx. Targeting P2Y6 signaling may be a potentially effective strategy for the treatment of alcoholic steatohepatitis.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Heterogeneity of non-alcoholic fatty liver disease (NAFLD): Implication for cardiovascular risk stratification

Francesco Baratta et al.

Summary: NAFLD is the most common liver disease worldwide and is strongly linked to atherosclerotic cardiovascular disease. It is a heterogeneous condition with various sub-phenotypes and outcomes, ranging from cardiovascular complications to liver damage progression. The contribution of environmental, metabolic, and genetic factors underlies this heterogeneity.

ATHEROSCLEROSIS (2022)

添加到收藏夹

Article Oncology

Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD

Chi Ma et al.

Summary: Platelets have been found to play a complex role in tumor growth regulation, as they can inhibit the growth of established liver cancer and activate CD8(+) T cells through P2Y12-dependent CD40L release.

CANCER CELL (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Gut bacteria alleviate smoking-related NASH by degrading gut nicotine

Bo Chen et al.

Summary: Tobacco smoking is positively correlated with non-alcoholic fatty liver disease (NAFLD), but the underlying mechanism is unclear. This study found that nicotine accumulates in the intestine during tobacco smoking and activates intestinal AMPK alpha. The gut bacterium Bacteroides xylanisolvens is identified as an effective nicotine degrader. These findings highlight the role of intestinal nicotine accumulation in NAFLD progression and the presence of an endogenous bacterium in the human intestine that can metabolize nicotine.

NATURE (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Deletion of TRPC3 or TRPC6 Fails to Attenuate the Formation of Inflammation and Fibrosis in Non-alcoholic Steatohepatitis

Kazuhiro Nishiyama et al.

Summary: TRPC3 and TRPC6 may not play a role in liver dysfunction and fibrosis in NASH model mice, as systemic deletion of these proteins failed to attenuate liver steatosis, inflammation, and fibrosis.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Purinergic P2X7 Receptor-NLRP3 Inflammasome Pathway: A New Target in Alcoholic Liver Disease?

Brendan Le Dare et al.

Summary: Alcohol consumption is closely associated with the development and progression of many non-communicable inflammatory diseases, particularly in the liver. Recent research suggests that Kupffer cells play a key role in the pathophysiology of alcoholic liver disease. Therefore, modulating purinergic signaling may represent a new approach for treating alcoholic liver disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Cell Biology

The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration

Mar Puigdellivol et al.

Summary: The P2Y(6) receptor plays a key role in mediating microglial phagocytosis of neurons induced by A beta and tau, leading to neuronal and memory loss. Knockout of this receptor could potentially be beneficial in the treatment of neurodegenerative diseases.

CELL REPORTS (2021)

添加到收藏夹

Article Cell Biology

IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism

Yasu-Taka Azuma et al.

Summary: IL-19, a member of the IL-10 family, plays a crucial role in NAFLD/NASH models by regulating liver metabolism and affecting steatosis and fibrosis. In vitro, IL-19's action can suppress lipid metabolism.

CELLS (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Transcriptomics Identify Thrombospondin-2 as a Biomarker for NASH and Advanced Liver Fibrosis

Kazuhiro Kozumi et al.

Summary: The study conducted global RNA sequencing of liver tissue from 98 NAFLD patients, identifying THBS2 as a potential biomarker for NASH and advanced fibrosis. Serum TSP-2 levels were independent predictors of NASH and advanced fibrosis, stratifying patients based on the risk of hepatic complications.

HEPATOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice

Theodomir Dusabimana et al.

Summary: The study shows that deficiency of P2Y2R can improve NAFLD induced by high-fat diet through various pathways, including enhancing insulin resistance, inhibiting hepatic lipid accumulation and injury, reducing fatty acid synthesis, and increasing fatty acid oxidation. This suggests that P2Y2R may be a promising therapeutic target for NAFLD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Expression of purinergic receptors on microglia in the animal model of choroidal neovascularisation

Lu Li et al.

Summary: The study showed that activated microglia can express P2 receptors after laser treatment, and the P2 receptor inhibitor, PPADS, can significantly affect microglial function and inhibit the formation of choroidal neovascularization.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Review Endocrinology & Metabolism

Purinergic Signaling in Liver Pathophysiology

Shanu Jain et al.

Summary: Research has shown that purinergic receptors play a vital role in regulating liver function and the development of liver diseases, suggesting potential therapeutic strategies by targeting adenosine, P2Y, and P2X receptors.

FRONTIERS IN ENDOCRINOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A single-cell type transcriptomics map of human tissues

Max Karlsson et al.

Summary: Advances in molecular profiling have enabled the creation of high-resolution single-cell type maps of human tissues, combining single-cell transcriptomics analysis with spatial antibody-based protein profiling. This technology allows researchers to explore the expression of human protein-coding genes and determine the number of elevated genes in different cell types, facilitating comparisons with bulk transcriptomics data. The analysis reveals distinct expression clusters corresponding to cell types with similar functions within and between organs.

SCIENCE ADVANCES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis

Shanu Jain et al.

Summary: Obesity is a major factor in the global epidemic of type 2 diabetes, with elevated plasma free fatty acids contributing to insulin resistance; adipocyte P2Y(14)Rs play a crucial role in regulating lipid and glucose homeostasis, with their absence enhancing lipolysis, reducing body weight, and improving glucose tolerance; P2Y(14)R antagonists may hold therapeutic potential for obesity and T2D by inhibiting lipolysis.

JCI INSIGHT (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

Update of P2Y Receptor Pharmacology: IUPHAR Review:27

Kenneth A. Jacobson et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Design and in vivo activity of A3 adenosine receptor agonist prodrugs

R. Rama Suresh et al.

PURINERGIC SIGNALLING (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Modulation of P2Y6R expression exacerbates pressure overload-induced cardiac remodeling in mice

Kakeru Shimoda et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Lack of adipocyte purinergic P2Y6 receptor greatly improves whole body glucose homeostasis

Shanu Jain et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Kazuhiro Nishiyama et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis

Zobair M. Younossi et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

GREIN: An Interactive Web Platform for Re-analyzing GEO RNA-seq Data

Naim Al Mahi et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Exacerbated intestinal inflammation in P2Y6 deficient mice is associated with Th17 activation

Mabrouka Salem et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

添加到收藏夹

Article Cell Biology

Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility

Kazuhiro Nishiyama et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Mice lacking adenosine 2A receptor reveal increased severity of MCD-induced NASH

Jing Zhou et al.

JOURNAL OF ENDOCRINOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH

Ying Lu et al.

PEERJ (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity

Yuli Cai et al.

HEPATOLOGY (2018)

添加到收藏夹

Article Gastroenterology & Hepatology

G alpha(12) overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells

Kyu Min Kim et al.

JOURNAL OF HEPATOLOGY (2018)

添加到收藏夹

Article Medicine, Research & Experimental

Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration

Tae Hyun Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

添加到收藏夹

Article Immunology

Microglia P2Y6 receptor is related to Parkinson's disease through neuroinflammatory process

Xiaodong Yang et al.

JOURNAL OF NEUROINFLAMMATION (2017)

添加到收藏夹

Review Pharmacology & Pharmacy

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

Akiyuki Nishimura et al.

PHARMACOLOGY & THERAPEUTICS (2017)

添加到收藏夹

Article Medical Laboratory Technology

Adenosine A2a receptor stimulation blocks development of nonalcoholic steatohepatitis in mice by multilevel inhibition of signals that cause immunolipotoxicity

Elisa Alchera et al.

TRANSLATIONAL RESEARCH (2017)

添加到收藏夹

Article Multidisciplinary Sciences

P2Y6-deficiency increases micturition frequency and attenuates sustained contractility of the urinary bladder in mice

Satoru Kira et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Aldehyde Detection in Electronic Cigarette Aerosols

Mumiye A. Ogunwale et al.

ACS OMEGA (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Molecular Pathogenesis of NASH

Alessandra Caligiuri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

添加到收藏夹

Review Neurosciences

Pharmacology and structure of P2Y receptors

Ivar von Kuegelgen et al.

NEUROPHARMACOLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Akiyuki Nishimura et al.

SCIENCE SIGNALING (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Akiyuki Nishimura et al.

SCIENCE SIGNALING (2016)

添加到收藏夹

Article Endocrinology & Metabolism

A2B Adenosine Receptors Prevent Insulin Resistance by Inhibiting Adipose Tissue Inflammation via Maintaining Alternative Macrophage Activation

Balazs Csoka et al.

DIABETES (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis

Suvarthi Das et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)

添加到收藏夹

Article Pathology

An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis

Masahiko Matsumoto et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

Akinobu Takaki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

A2b Adenosine Receptor Regulates Hyperlipidemia and Atherosclerosis

Milka Koupenova et al.

CIRCULATION (2012)

添加到收藏夹

Article Medicine, Research & Experimental

Adenosine A2a receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats

Chiara Imarisio et al.

CLINICAL SCIENCE (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice

Saurabh Chatterjee et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

添加到收藏夹

Article Multidisciplinary Sciences

The A2b Adenosine Receptor Modulates Glucose Homeostasis and Obesity

Hillary Johnston-Cox et al.

PLOS ONE (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Links Between Insulin Resistance, Adenosine A2B Receptors, and Inflammatory Markers in Mice and Humans

Robert A. Figler et al.

DIABETES (2011)

添加到收藏夹

Article Immunology

P2Y6 Agonist Uridine 5′-Diphosphate Promotes Host Defense against Bacterial Infection via Monocyte Chemoattractant Protein-1-Mediated Monocytes/Macrophages Recruitment

Zhi Zhang et al.

JOURNAL OF IMMUNOLOGY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepatitis IMPACT ON MITOCHONDRIAL S-ADENOSYL-L-METHIONINE AND GLUTATHIONE

Francisco Caballero et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

添加到收藏夹

Article Medicine, Research & Experimental

Adenosine signaling contributes to ethanol-induced fatty liver in mice

Zhongsheng Peng et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

P2Y6 receptor-Gα12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis

Motohiro Nishida et al.

EMBO JOURNAL (2008)

添加到收藏夹

Article Pharmacology & Pharmacy

Knockout mice reveal a role for P2Y6 receptor in macrophages, endothelial cells, and vascular smooth muscle cells

Isabelle Bar et al.

MOLECULAR PHARMACOLOGY (2008)

添加到收藏夹

Article Pharmacology & Pharmacy

The current state of serum biomarkers of hepatotoxicity

Josef Ozer et al.

TOXICOLOGY (2008)

添加到收藏夹

Article Pathology

Diabetes-induced alterations of adenosine receptors expression level in rat liver

Marzena Grden et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2007)

添加到收藏夹

Article Multidisciplinary Sciences

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Schuichi Koizumi et al.

NATURE (2007)

添加到收藏夹

Article Medicine, General & Internal

Smoking and inflammatory bowel disease: A meta-analysis

Suhal S. Mahid et al.

MAYO CLINIC PROCEEDINGS (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1

Gizem Rizki et al.

JOURNAL OF LIPID RESEARCH (2006)

添加到收藏夹

Article Gastroenterology & Hepatology

Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2

John Willy Haukeland et al.

JOURNAL OF HEPATOLOGY (2006)

添加到收藏夹

Article Physiology

Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy

AS Awad et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)

添加到收藏夹

Article Gastroenterology & Hepatology

Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease

M Odashima et al.

GASTROENTEROLOGY (2005)

添加到收藏夹

Article Gastroenterology & Hepatology

Lack of peroxisome proliferator-activated receptor α in mice enhances methionine and choline deficient diet-induced steatohepatitis

PV Kashireddy et al.

HEPATOLOGY RESEARCH (2004)

添加到收藏夹

Article Gastroenterology & Hepatology

Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells

JA Dranoff et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2004)

添加到收藏夹

Article Immunology

Cutting edge: Physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo

D Lukashev et al.

JOURNAL OF IMMUNOLOGY (2004)

添加到收藏夹

Article Endocrinology & Metabolism

Increase in adenosine A1 receptor gene expression in the liver of streptozotocin-induced diabetic rats

IM Liu et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.