Revealing the Role of Alternariol in the Local Steroidogenesis in Human Prostate Normal and Cancer Cells

The mycotoxin alternariol (AOH) can be found in food products infected by Alternaria spp. and is considered an endocrine-disruptive mycotoxin. The main mechanism of AOH toxicity is associated with DNA damage and modulation of the inflammation process. Still, AOH is considered as one of the emerging mycotoxins. In this study, we have evaluated how AOH might affect the local steroidogenesis process in the prostate, in both normal and cancer cells. We have found that AOH itself modulates the cell cycle, inflammation, and apoptosis, rather than the steroidogenesis process in prostate cancer cells; however, in the presence of another steroidogenic agent, the influence on steroidogenesis is significant. Therefore, this is the first study to report the effect of AOH on local steroidogenesis in normal and prostate cancer cells. We postulate that AOH might modulate the release of the steroid hormones and expression of the key components by interfering with the steroidogenic pathway and might be considered a steroidogenesis-altering agent.

Automated summary

This study evaluates the impact of AOH on the local steroidogenesis process in normal and prostate cancer cells. The findings suggest that while AOH has a significant impact on cell cycle, inflammation, and apoptosis in prostate cancer cells, its influence on steroidogenesis is not significant. However, when combined with another steroidogenic agent, AOH significantly affects steroidogenesis.