Ergotamine Stimulates Human 5-HT4-Serotonin Receptors and Human H2-Histamine Receptors in the Heart

Article Clinical Neurology

Trends in utilization and costs of migraine medications, 2017-2020

Jennifer L. Nguyen et al.

Summary: This study provides insights into the changes in utilization and costs trends associated with migraine medications. The increased utilization of CGRP mABs has significantly contributed to the increased costs.

JOURNAL OF HEADACHE AND PAIN (2022)

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Article Pharmacology & Pharmacy

Functional interaction of H-2-receptors and 5HT(4)-receptors in atrial tissues isolated from double transgenic mice and from human patients

Joachim Neumann et al.

Summary: The study revealed a functional interaction between histamine and serotonin in the heart of double transgenic mice, leading to an impact on cardiac muscle contraction due to the joint overexpression of receptors. Additionally, a similar interaction was found in the muscle fibers of the human right atrium.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Amitriptyline functionally antagonizes cardiac H2 histamine receptors in transgenic mice and human atria

Joachim Neumann et al.

Summary: The study demonstrated that amitriptyline acts as an antagonist of contractility at H(2)Rs in H2R-TG mouse hearts and in the human heart. This finding may help explain the side effects of amitriptyline.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H2-histamine-receptor activation in isolated atria of transgenic mice

Joachim Neumann et al.

Summary: Histamine exerts cAMP-dependent positive inotropic effects (PIE) on the left and right atria of transgenic mice which overexpress the human H-2-receptor, with PDE 3 and PDE 4 regulating the effects on inotropic response, while PDE 2 and PDE 4 play a role in regulating the positive chronotropic effects on heart beat rate.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions

Joachim Neumann et al.

Summary: This review discusses the pharmacological, structural, and functional relationships between H-2-histamine receptors and H-1-histamine receptors in the mammalian heart, focusing on their role in regulating heart force and rhythm, potential clinical applications in cardiac diseases, and the effects on cardiac arrhythmias. It also highlights novel findings, limitations in current understanding, and suggests future research directions, including the possible development of cardiomyocyte-specific H-2-histamine receptor agonists and antagonists.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Histamine can be Formed and Degraded in the Human and Mouse Heart

Joachim Neumann et al.

Summary: This study explores the physiological role of histamine in the mouse and human heart, and demonstrates that inhibiting histamine-metabolizing enzymes can alter the beating rate and force of the human heart.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Cardiac Effects of Novel Histamine H2 Receptor Agonists

Ulrich Gergs et al.

Summary: The three newly developed H-2 receptor agonists demonstrated increased cardiac effects in H-2-TG mice, but not in WT mice. These effects were antagonized by the H-2 receptor antagonist famotidine. The agonists also increased left ventricular ejection fraction in H-2-TG mice, suggesting potential therapeutic benefits for neurological disorders and congestive heart failure.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2021)

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Article Food Science & Technology

A Targeted UHPLC-MS/MS Method Validated for the Quantification of Ergot Alkaloids in Cereal-Based Baby Food from the Belgian Market

Bart Huybrechts et al.

Summary: A new UHPLC-MS/MS method has been developed for quantifying ergot alkaloids in dry cereal-based baby food, which is important for compliance with the new legislation in the European Union. The method showed good sensitivity, accuracy, and precision, and has been applied to samples from the Belgian market with promising results.

TOXINS (2021)

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Review Chemistry, Multidisciplinary

Biosynthesis and synthetic biology of psychoactive natural products

Cooper S. Jamieson et al.

Summary: Psychoactive natural products play a critical role in the modern world, with their complex structures having significant medicinal value. Efforts over the past two centuries have been focused on elucidating the biosynthetic pathways of these molecules, and recent advancements in genomics and molecular biology have greatly contributed to this research progress.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Pharmacology & Pharmacy