期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms24065954
关键词
HER-2/neu; prostate cancer; survival; IL-8; TGF-beta; CD8+T cell immunity; HER-2((780-788))
This study investigated the prognostic role of HER-2/neu-specific T cell immunity in prostate cancer patients. The results showed that high frequencies of HER-2/neu-specific CD8+ T lymphocytes were associated with better progression-free survival and lower levels of TGF-beta and IL-8 in patients receiving standard treatment.
HER-2/neu is the human epidermal growth factor receptor 2, which is associated with the progression of prostate cancer (PCa). HER-2/neu-specific T cell immunity has been shown to predict immunologic and clinical responses in PCa patients treated with HER-2/neu peptide vaccines. However, its prognostic role in PCa patients receiving conventional treatment is unknown, and this was addressed in this study. The densities of CD8+ T cells specific for the HER-2/neu((780-788)) peptide in the peripheral blood of PCa patients under standard treatments were correlated with TGF-beta/IL-8 levels and clinical outcomes. We demonstrated that PCa patients with high frequencies of HER-2/neu((780-788))-specific CD8+ T lymphocytes had better progression-free survival (PFS) as compared with PCa patients with low frequencies. Increased frequencies of HER-2/neu((780-788))-specific CD8+ T lymphocytes were also associated with lower levels of TGF-beta and IL-8. Our data provide the first evidence of the predictive role of HER-2/neu-specific T cell immunity in PCa.
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