Unlocking STING as a Therapeutic Antiviral Strategy

Invading pathogens have developed weapons that subvert physiological conditions to weaken the host and permit the spread of infection. Cells, on their side, have thus developed countermeasures to maintain cellular physiology and counteract pathogenesis. The cyclic GMP-AMP (cGAMP) synthase (cGAS) is a pattern recognition receptor that recognizes viral DNA present in the cytosol, activating the stimulator of interferon genes (STING) protein and leading to the production of type I interferons (IFN-I). Given its role in innate immunity activation, STING is considered an interesting and innovative target for the development of broad-spectrum antivirals. In this review, we discuss the function of STING; its modulation by the cellular stimuli; the molecular mechanisms developed by viruses, through which they escape this defense system; and the therapeutical strategies that have been developed to date to inhibit viral replication restoring STING functionality.

Automated summary

Invading pathogens weaken the host by subverting physiological conditions, while cells have developed countermeasures to maintain cellular physiology and counteract pathogenesis. The cGAS-STING pathway plays a crucial role in innate immunity activation by recognizing viral DNA and producing IFN-I. Targeting STING has the potential for developing broad-spectrum antivirals, and this review explores the function of STING, its modulation, viral evasion mechanisms, and therapeutic strategies to restore its functionality.