4.7 Review

Emerging Evidence on Membrane Estrogen Receptors as Novel Therapeutic Targets for Central Nervous System Pathologies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

Improvement of Cardiovascular Function in Aging Females by the Prolonged Activation of G Protein-Coupled Estrogen Receptor

Jipeng Ma et al.

Summary: There is ample evidence suggesting that estrogen replacement therapy has beneficial effects on cardiovascular diseases when initiated close to menopause. However, little is known about the complex interactions between hormone receptors after menopause. This study found that GPER activation can inhibit age-dependent coronary artery dysfunction and cardiac dysfunction only when androgen receptors and classical estrogen receptors are blocked in aged female rats.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2023)

Article Environmental Sciences

TET1 involved in bisphenol A induced TM3 Leydig cell toxicity by regulating Cav3.3 hydroxymethylation

Shi-meng Zhou et al.

Summary: This study revealed the mechanism of BPA-induced toxicity in Leydig cells. Results showed that BPA inhibited cell proliferation and increased apoptosis. TET1 was involved in the toxic response induced by BPA and exerted its function by regulating Cav3.3 DNA hydroxymethylation modification. These findings suggest that TET1 may serve as an epigenetic marker for reproductive toxicity induced by BPA exposure and provide a new direction for research on male reproductive damage.

CHEMOSPHERE (2023)

Article Medicine, Research & Experimental

Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance

Yingfu Jiao et al.

Summary: GPER is a marker for GABAergic ON cells, and it plays a role in the hormonal regulation of pain and analgesia. Activation of GPER facilitates pain while its ablation attenuates pain and enhances morphine analgesia. Therefore, GPER is a promising target for pain treatment and prevention of opioid tolerance.

JOURNAL OF CLINICAL INVESTIGATION (2023)

Article Biochemistry & Molecular Biology

Novel GPER Agonist, CITFA, Increases Neurite Growth in Rat Embryonic (E18) Hippocampal Neurons

Chelsea DeLeon et al.

Summary: This study identified 10 novel compounds with neuroprotective effects, among which one called CIFTA significantly promoted axonal and dendritic growth in neurons. Results from treating E18 hippocampal neurons showed that neurite outgrowth in response to G-1 and CIFTA originated from GPER activation.

ACS CHEMICAL NEUROSCIENCE (2022)

Article Biochemistry & Molecular Biology

G-Protein-Coupled Estrogen Receptor Expression in Rat Uterine Artery Is Increased by Pregnancy and Induces Dilation in a Ca2+ and ERK1/2 Dependent Manner

Teresa Tropea et al.

Summary: Increasing levels of estrogens in pregnancy contribute to the physiological adaptations of maternal vasculature. The GPER receptor plays a role in regulating uteroplacental blood flow through vasorelaxation in the uterine arteries. This study found that GPER expression and vasorelaxation are increased in pregnant rats compared to non-pregnant rats, suggesting the involvement of GPER in the regulation of uteroplacental blood flow during pregnancy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Neurosciences

Estrogen receptors observed at extranuclear neuronal sites and in glia in the nucleus accumbens core and shell of the female rat: Evidence for localization to catecholaminergic and GABAergic neurons

Anne Almey et al.

Summary: This study suggests that the localization of estrogen receptors (ERs) in the nucleus accumbens (NAc) could explain the rapid effects of estrogens in this region. ER α, ER β, and GPER1 are mainly observed at extranuclear sites in the NAc, particularly in axons and axon terminals in the core and shell. Some ER α and GPER1 are found in catecholaminergic terminals, while a larger proportion is localized to GABAergic dendrites and terminals, indicating that estrogens indirectly affect dopamine transmission by altering GABAergic transmission.

JOURNAL OF COMPARATIVE NEUROLOGY (2022)

Article Biochemistry & Molecular Biology

Icaritin inhibits neuroinflammation in a rat cerebral ischemia model by regulating microglial polarization through the GPER-ERK-NF-κB signaling pathway

Zining Yu et al.

Summary: The study found that ICT can inhibit microglial activation and M1 polarization, promote M2 polarization, and alleviate inflammatory response and achieve neuroprotection by regulating the GPER-ERK-NF-kappa B signaling pathway.

MOLECULAR MEDICINE (2022)

Article Cardiac & Cardiovascular Systems

Sex differences in vascular aging and impact of GPER deletion

Benard O. Ogola et al.

Summary: Indices of vascular aging differ between male and female mice. Sex differences in pulse wave velocity, blood pressure, and large artery stiffness disappear in middle-aged mice, but the female advantage in resistance artery vasodilator function is maintained. GPER deletion abolishes these sex differences and significantly reduces endothelial function in adult female mice. Further studies are needed to characterize sex differences in vascular aging for personalized early detection and treatment of vascular diseases.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

Article Biochemistry & Molecular Biology

Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist

Yi He et al.

Summary: This study found that ovarian cancer stem cells (OCSCs) highly express ER beta, and the ER beta agonist LY500307 can significantly reduce the viability of OCSCs, inhibit sphere formation, self-renewal, and invasion, and promote apoptosis and G2/M cell cycle arrest. Further investigation revealed that LY500307 exerts its effects by modulating pathways related to cell cycle and apoptosis. Additionally, LY500307 treatment attenuated the tumor-initiating capacity of OCSCs in mice. These findings demonstrate that LY500307 is a promising novel therapeutic agent for ovarian cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Effects of Dietary n-3 LCPUFA Supplementation on the Hippocampus of Aging Female Mice: Impact on Memory, Lipid Raft-Associated Glutamatergic Receptors and Neuroinflammation

Lucas Taoro-Gonzalez et al.

Summary: Recent findings suggest that changes in brain lipid composition during aging can affect the integrity and protein signaling of lipid rafts, leading to memory impairment. However, a n-3 LCPUFA-enriched diet has been shown to improve cognitive function and stabilize the lipid composition of hippocampal lipid rafts in aged mice. These findings suggest that n-3 LCPUFA supplementation may have a rejuvenating effect on the microenvironment of lipid rafts, enhancing cognitive performance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Biochemistry & Molecular Biology

Activation of G protein-coupled estrogen receptor fine-tunes age-related decreased vascular activities in the aortae of female and male rats

Xuan Yu et al.

Summary: This study found that GPER activation improves vascular activities in aging female rats in response to ET-1 and ACh stimulation. The aortic contractile and relaxation responses were reduced in middle-aged female rats compared to young adult female rats. This effect was not observed in male rats. Therefore, GPER may be a potential drug target in cardiovascular disease in women.

STEROIDS (2022)

Article Neurosciences

Differential Effects of the G-Protein-Coupled Estrogen Receptor (GPER) on Rat Embryonic (E18) Hippocampal and Cortical Neurons

Kyle Pemberton et al.

Summary: Estrogen plays important roles in nervous system development and function. The activation of GPER has differential effects on rat hippocampal and cortical neurons, with a stronger response observed in hippocampal neurons. The GPER-mediated increase in Ca2+ in hippocampal neurons involves both the release of intracellular Ca2+ stores and the entry of extracellular Ca2+ through Ca2+ channels.

ENEURO (2022)

Article Cell Biology

ESR1 dysfunction triggers neuroinflammation as a critical upstream causative factor of the Alzheimer's disease process

Junying Liu et al.

Summary: Alzheimer's disease is a major cause of dementia worldwide, with advanced age and female sex being significant risk factors. This study investigates the molecular mechanisms underlying the association between estrogen receptor genetic polymorphisms and Alzheimer's disease. Using bioinformatics tools, the study reveals the involvement of axonal guidance and inflammation-related gene markers in Alzheimer's disease pathogenesis. Additionally, the study identifies potential therapeutic targets and natural products for personalized treatment of Alzheimer's disease.

AGING-US (2022)

Article Neurosciences

Membrane estrogen receptor ERa activation improves tau clearance via autophagy induction in a tauopathy cell model

Angelica Jardim Costa et al.

Summary: Alzheimer's disease (AD) is a neurodegenerative disease associated with aging, which is more common in women than men. Hormone replacement therapy, particularly estrogen, has been shown to reduce memory loss in menopausal women by inducing autophagy to remove protein aggregates. This study found that 17β-estradiol induces autophagy by activating AMPK, independent of mTOR signals. Furthermore, it was discovered that 17β-estradiol increases LC3-II levels and clears tau protein through autophagy.

BRAIN RESEARCH (2022)

Article Neurosciences

The novel estrogen modulator STX attenuates Amyloid-β neurotoxicity in the 5XFAD mouse model of Alzheimer's disease

Joseph F. Quinn et al.

Summary: This study aims to evaluate the neuroprotective effects of the non-steroidal estrogen receptor modulator STX in a mouse model of Alzheimer's Disease. The results suggest that oral STX treatment can attenuate A beta-associated mitochondrial toxicity and synaptic toxicity, improve spatial memory, and reduce markers for reactive astrocytosis and microgliosis. The neuroprotective effects of STX were more prominent in females.

NEUROBIOLOGY OF DISEASE (2022)

Review Endocrinology & Metabolism

Targeting the non-classical estrogen pathway in neurodegenerative diseases and brain injury disorders

Zsombor Koszegi et al.

Summary: Estrogens can have a significant impact on the biology of various tissues and organs, including the brain. They play a vital role in maintaining homeostasis and have been shown to exert neuroprotective effects, particularly in neurodegenerative diseases and brain injury disorders. While the classical effects of estrogen through intracellular receptors are well-established, the non-classical pathway through membrane receptors and rapid intracellular signaling cascades is still being actively researched. Compounds targeting the non-classical estrogen pathway show promise as potential treatments for neurodegenerative diseases and brain injury disorders.

FRONTIERS IN ENDOCRINOLOGY (2022)

Article Neurosciences

E2-BSA and G1 exert neuroprotective effects and improve behavioral abnormalities following traumatic brain injury: The role of classic and non-classic estrogen receptors

Ladan Amirkhosravi et al.

Summary: This study evaluated the role of classical and non-classical estrogen receptors in mediating the neuroprotective effects of estrogen after traumatic brain injury. The results showed that E2, E2-BSA, and G1 prevented brain edema and cognitive deficiency, while their effects were inhibited by ICI and G15.

BRAIN RESEARCH (2021)

Review Endocrinology & Metabolism

The role of Gα protein signaling in the membrane estrogen receptor-mediated signaling

Shuhui Zheng et al.

Summary: G alpha plays a crucial role in mER-mediated signaling, involving processes such as vascular EC migration, endothelial H2S release, breast cancer cell invasion, neural regulation of energy balance, and osteogenesis.

GYNECOLOGICAL ENDOCRINOLOGY (2021)

Review Biochemistry & Molecular Biology

The Role of Estrogen Receptors and Their Signaling across Psychiatric Disorders

Wu Jeong Hwang et al.

Summary: This review highlights the role of estrogen and estrogen signaling in psychiatric disorders, emphasizing their impact on brain functions and neuroprotection. The potential therapeutic use of estrogen in treating psychiatric disorders is explored, along with disruptions in estrogen signaling and their implications for pathophysiologies in these disorders. Insights from this review suggest potential novel treatment strategies involving estrogen and its signaling pathways.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction

Jaqueline S. da Silva et al.

Summary: Estrogen receptors (ER) have various functions in different systems, with E2 playing a protective role in the heart by regulating vascular and cardiac cells. Research has shown that ER regulates cardiovascular function through genomic or non-genomic pathways, making it a potential target for treating myocardial infarction-induced cardiac dysfunction.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Estrogen Receptors as Molecular Targets of Endocrine Therapy for Glioblastoma

Andrea Magali Gonzalez-Mora et al.

Summary: Hormonal factors, specifically estrogen receptors (ERs), may play a role in the development and treatment of glioblastoma. Understanding the function of ERs could lead to the development of more effective therapies for this aggressive brain tumor.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Prenatal Exposure to Triclocarban Impairs ESR1 Signaling and Disrupts Epigenetic Status in Sex-Specific Ways as Well as Dysregulates the Expression of Neurogenesis- and Neurotransmitter-Related Genes in the Postnatal Mouse Brain

Agnieszka Wnuk et al.

Summary: Triclocarban is identified as a neurodevelopmental risk factor that targets ESR1, affects apoptosis and autophagy in a sex-specific manner, and disrupts the epigenetic status of brain tissue while dysregulating the postnatal expression of neurogenesis- and neurotransmitter-related genes.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Neurosciences

Endolysosome Localization of ERa Is Involved in the Protective Effect of 17α-Estradiol against HIV-1 gp120-Induced Neuronal Injury

Gaurav Datta et al.

Summary: Neurotoxic HIV-1 viral proteins contribute to the development of HIV-associated neurocognitive disorder (HAND), with estrogen, particularly 17a-estradiol (17aE2), shown to offer neuroprotection through an endolysosome-dependent pathway. These findings suggest potential for novel therapeutic strategies against HAND.

JOURNAL OF NEUROSCIENCE (2021)

Review Biochemistry & Molecular Biology

Estrogenic hormones receptors in Alzheimer's disease

Angeles C. Tecalco-Cruz et al.

Summary: The reduction of estrogen receptors in women during aging appears to facilitate the progression of Alzheimer's disease.

MOLECULAR BIOLOGY REPORTS (2021)

Article Neurosciences

Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1

A. Wnuk et al.

Summary: The study demonstrates that PaPE-1 can inhibit hypoxia/ischemia-induced neuronal death in a delayed posttreatment, with a reduction in neurotoxicity and neurodegeneration. The neuroprotective effect is achieved through reducing ROS formation and restoring cellular metabolic activity.

NEUROTOXICITY RESEARCH (2021)

Article Medical Laboratory Technology

Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems

Alan R. Gintzler et al.

Summary: This study examines the pliability of nociception and opioid antinociception in females over the reproductive cycle. The findings suggest that spinal estrogenic signaling plays a crucial role in coordinating functionality between pronociception and antinociception. Additionally, the pharmacological manipulation of intrinsic opioid analgesic/anti-allodynic systems has translational relevance in pain management strategies.

TRANSLATIONAL RESEARCH (2021)

Review Neurosciences

The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?

Felipe A. Bustamante-Barrientos et al.

Summary: Estrogens and estrogen-like molecules have a significant impact on the biology of various cell types, with estrogen receptors playing a crucial role in modulating cell proliferation, differentiation, and survival, particularly in the central nervous system. Estrogens can exert neuroprotective roles, regulate the balance between proliferation and differentiation of neural stem/progenitor cells, and influence neurogenesis through multiple mechanisms.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Article Multidisciplinary Sciences

H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions

Yichao Cai et al.

Summary: The removal of components in H3K27me3-rich regions by CRISPR leads to upregulation of target genes in interaction, along with changes in chromatin interactions. Cells lacking H3K27me3-rich regions show altered phenotype associated with cell identity, and changes in xenograft tumor growth.

NATURE COMMUNICATIONS (2021)

Article Nutrition & Dietetics

Pathway Preferential Estrogens Prevent Hepatosteatosis Due to Ovariectomy and High-Fat Diets

Qianying Zuo et al.

Summary: The novel estrogen receptor ligand PaPE-1 has been shown to have beneficial effects on metabolic tissues, decreasing the risk of fatty liver disease in postmenopausal women without increasing reproductive cancer risk. This suggests that PaPE-1 may serve as a safer alternative to hormone replacement therapy for improving postmenopausal metabolic health.

NUTRIENTS (2021)

Article Neurosciences

Ginsenoside Rg1 Prevents Cognitive Impairment and Hippocampal Neuronal Apoptosis in Experimental Vascular Dementia Mice by Promoting GPR30 Expression

Fengming Shen et al.

Summary: This study demonstrates that ginsenoside Rg1 prevents cognitive impairment and hippocampal neuronal apoptosis in VD mice by promoting GPR30 expression, providing important implications for the application of Rg1 in the treatment of VD.

NEURAL PLASTICITY (2021)

Review Cell Biology

G Protein-Coupled Estrogen Receptor in Cancer and Stromal Cells: Functions and Novel Therapeutic Perspectives

Richard A. Pepermans et al.

Summary: Estrogen plays crucial roles in various cancers, metabolism, and immune regulation. The G protein-coupled estrogen receptor (GPER) has been found to contribute to endocrine therapy resistance in breast cancer and has potential therapeutic value in targeting other diseases such as obesity and diabetes. Ongoing clinical trials are exploring the use of GPER-selective agonists like G-1 in combination with immune checkpoint inhibition for cancer treatment.
Article Neurosciences

G protein-coupled estrogen receptor in the rostral ventromedial medulla contributes to the chronification of postoperative pain

Jia-Jia Xu et al.

Summary: The study revealed the crucial role of GPER in the RVM in the chronification of postoperative pain, possibly involving the MOR phosphorylation pathway.

CNS NEUROSCIENCE & THERAPEUTICS (2021)

Review Biochemistry & Molecular Biology

From Menopause to Neurodegeneration-Molecular Basis and Potential Therapy

Yu-Jung Cheng et al.

Summary: The impacts of menopause on neurodegenerative diseases, especially the changes in steroid hormones, have been described in cell, animal, and human models. The therapeutic effects of hormone replacement therapy on postmenopausal women with neurodegenerative diseases remain controversial due to the complex response of signaling pathways to aging and hormone treatments. Estrogen, progesterone, and IGF-1 play important roles in neuroprotection and their decreased levels during menopause are associated with disease progression, particularly Alzheimer's disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

ER-alpha 36 Promotes the Malignant Progression of Cervical Cancer Mediated by Estrogen via HMGA2

Chunyan Wang et al.

Summary: Estrogen receptor alfa 36 (ER-alpha 36) is over-expressed in cervical cancer tissues and associated with poor prognosis in patients. High expression of ER-alpha 36 promotes proliferation, invasion, and metastasis of cervical cancer cells, with HMGA2 identified as a downstream target. Knockdown of HMGA2 attenuates the oncogenic effects of ER-alpha 36. High expression of ER-alpha 36 may serve as a prognostic biomarker and treatment target in cervical cancer.

FRONTIERS IN ONCOLOGY (2021)

Article Neurosciences

Role for the membrane estrogen receptor alpha in the sexual differentiation of the brain

Badr Khbouz et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2020)

Article Cell Biology

Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

Geetanjali Sharma et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Review Biology

Diabetes as a risk factor for Alzheimer's disease in the Middle East and its shared pathological mediators

Richard L. Jayaraj et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2020)

Article Endocrinology & Metabolism

17β-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERα signaling

Kaifan Yu et al.

MOLECULAR METABOLISM (2020)

Review Endocrinology & Metabolism

A Role for Estrogen Receptor alpha36 in Cancer Progression

Maria Teresa Pagano et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Endocrinology & Metabolism

Rapid membrane effect of estrogens on stimulation of corticotropin-releasing hormone

Yang-Jian Qi et al.

PSYCHONEUROENDOCRINOLOGY (2020)

Review Biochemistry & Molecular Biology

Structure and Dynamics of GPCRs in Lipid Membranes: Physical Principles and Experimental Approaches

Andrew J. Y. Jones et al.

MOLECULES (2020)

Review Endocrinology & Metabolism

GPER as a Receptor for Endocrine-Disrupting Chemicals (EDCs)

Severine Perian et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy

Nobuaki Fukuma et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2020)

Review Neurosciences

Dendritic Spine Plasticity: Function and Mechanisms

Karen Runge et al.

FRONTIERS IN SYNAPTIC NEUROSCIENCE (2020)

Article Biochemistry & Molecular Biology

Membrane-initiated estrogen signaling via Gq-coupled GPCR in the central nervous system

Gwyndolin Vail et al.

STEROIDS (2019)

Article Endocrinology & Metabolism

ERαΔ4, an ERα splice variant missing exon4, interacts with caveolin-3 and mGluR2/3

Angela M. Wong et al.

JOURNAL OF NEUROENDOCRINOLOGY (2019)

Review Endocrinology & Metabolism

The role of G protein-coupled estrogen receptor 1 on neurological disorders

C. Roque et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2019)

Article Biochemistry & Molecular Biology

17?-Estradiol nongenomically induces vascular endothelial H2S release by promoting phosphorylation of cystathionine ?-lyase

Xingyan Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Endocrine disruption through membrane estrogen receptors and novel pathways leading to rapid toxicological and epigenetic effects

Cheryl S. Rosenfeld et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

Article Medicine, Research & Experimental

Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer

Cai-xia Zhu et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2018)

Article Biochemistry & Molecular Biology

Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons

Agnieszka Wnuk et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

Review Biochemistry & Molecular Biology

GPER1/GPR30 in the brain: Crosstalk with classical estrogen receptors and implications for behavior

Maria M. Hadjimarkou et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

Article Behavioral Sciences

GPR30 activation improves memory and facilitates DHPG-induced LTD in the hippocampal CA3 of middle-aged mice

Wen Xu et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2018)

Article Biochemistry & Molecular Biology

Membrane estrogen receptors signal to determine transcription factor function

Ellis R. Levin

STEROIDS (2018)

Article Biochemistry & Molecular Biology

N-terminal truncations in sex steroid receptors and rapid steroid actions

Derek A. Schreihofer et al.

STEROIDS (2018)

Article Neurosciences

Memory-Related Synaptic Plasticity Is Sexually Dimorphic in Rodent Hippocampus

Weisheng Wang et al.

JOURNAL OF NEUROSCIENCE (2018)

Review Behavioral Sciences

Sex differences and the effects of estradiol on striatal function

John Meitzen et al.

CURRENT OPINION IN BEHAVIORAL SCIENCES (2018)

Review Biochemistry & Molecular Biology

Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System

Agnieszka Wnuk et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Biochemistry & Molecular Biology

Activation of G-protein coupled estrogen receptor 1 improves early-onset cognitive impairment via PI3K/Akt pathway in rats with traumatic brain injury

Ze-Fen Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Medicine, General & Internal

Diabetes and Stroke: Epidemiology, Pathophysiology, Pharmaceuticals and Outcomes

Rong Chen et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2016)

Article Neurosciences

STX, a Novel Membrane Estrogen Receptor Ligand, Protects Against Amyloid-β Toxicity

Nora E. Gray et al.

JOURNAL OF ALZHEIMERS DISEASE (2016)

Article Multidisciplinary Sciences

The role of membrane ERα signaling in bone and other major estrogen responsive tissues

K. L. Gustafsson et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Neuroprotective action of raloxifene against hypoxia-induced damage in mouse hippocampal cells depends on ERα but not ERβ or GPR30 signalling

J. Rzemieniec et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Review Neurosciences

Update on the Neuroprotective Effect of Estrogen Receptor Alpha Against Alzheimer's Disease

Yu-Long Lan et al.

JOURNAL OF ALZHEIMERS DISEASE (2015)

Article Biochemistry & Molecular Biology

Recent insights into non-nuclear actions of estrogen receptor alpha

Subhashis Banerjee et al.

STEROIDS (2014)

Article Multidisciplinary Sciences

G Protein-coupled Estrogen Receptor Protects from Atherosclerosis

Matthias R. Meyer et al.

SCIENTIFIC REPORTS (2014)

Review Biotechnology & Applied Microbiology

Estrogen Deficiency and the Origin of Obesity during Menopause

Fernando Lizcano et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Biochemistry & Molecular Biology

Stroke Increases G Protein-Coupled Estrogen Receptor Expression in the Brain of Male but Not Female Mice

Brad R. S. Broughton et al.

NEUROSIGNALS (2013)

Article Clinical Neurology

The Effects of Estrogen in Ischemic Stroke

Edward C. Koellhoffer et al.

TRANSLATIONAL STROKE RESEARCH (2013)

Article Endocrinology & Metabolism

CAV1 siRNA Reduces Membrane Estrogen Receptor-α Levels and Attenuates Sexual Receptivity

Amy Christensen et al.

ENDOCRINOLOGY (2012)

Review Endocrinology & Metabolism

Convergence of Multiple Mechanisms of Steroid Hormone Action

S. K. Mani et al.

HORMONE AND METABOLIC RESEARCH (2012)

Article Biochemistry & Molecular Biology

Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells

Robert X. -D. Song et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Role of estrogen receptors, PKC and Src in ERK2 and p38 MAPK signaling triggered by 17β-estradiol in skeletal muscle cells

Ana C. Ronda et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)

Article Endocrinology & Metabolism

Xenoestrogen-Induced Regulation of EZH2 and Histone Methylation via Estrogen Receptor Signaling to PI3K/AKT

Tiffany G. Bredfeldt et al.

MOLECULAR ENDOCRINOLOGY (2010)

Article Multidisciplinary Sciences

Estradiol inhibits ongoing autoimmune neuroinflammation and NFκB-dependent CCL2 expression in reactive astrocytes

Sebastien N. Giraud et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Oncology

GPR30 predicts poor survival for ovarian cancer

Harriet O. Smith et al.

GYNECOLOGIC ONCOLOGY (2009)

Article Biochemistry & Molecular Biology

Role of estrogen receptor α in membrane-initiated signaling in neural cells: Interaction with IGF-1 receptor

Raquel Marin et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2009)

Review Cell Biology

Mechanisms of estrogen signaling and gene expression via GPR30

Eric R. Prossnitz et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2009)

Article Neurosciences

VDAC and ERα interaction in caveolae from human cortex is altered in Alzheimer's disease

Cristina M. Ramirez et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2009)

Article Endocrinology & Metabolism

Involvement of G Protein-Coupled Receptor 30 (GPR30) in Rapid Action of Estrogen in Primate LHRH Neurons

Sekoni D. Noel et al.

MOLECULAR ENDOCRINOLOGY (2009)

Review Biochemistry & Molecular Biology

Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER

Eric R. Prossnitz et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2009)

Review Endocrinology & Metabolism

Plasma membrane estrogen receptors

Ellis R. Levin

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2009)

Article Neurosciences

Caveolin proteins are essential for distinct effects of membrane estrogen receptors in neurons

Marissa I. Boulware et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Endocrinology & Metabolism

The risk of venous thromboembolism is markedly elevated in patients with diabetes

V Petrauskiene et al.

DIABETOLOGIA (2005)

Article Biochemistry & Molecular Biology

S-palmitoylation modulates human estrogen receptor-α functions

F Acconcia et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Endocrinology & Metabolism

A membrane estrogen receptor mediates intracellular calcium release in astrocytes

VV Chaban et al.

ENDOCRINOLOGY (2004)

Article Endocrinology & Metabolism

Plasma membrane estrogen receptors exist and functions as dimers

M Razandi et al.

MOLECULAR ENDOCRINOLOGY (2004)