期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 370, 期 -, 页码 145-151出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2016.09.043
关键词
V180I genetic Creutzfeldt-Jakob disease; SPELT; MRI; End-stage
资金
- Research Committee of Prion Disease and Slow Virus infection
- Prion Disease Surveillance [H26, Nanbyo-Shitei 002]
- Ministry of Health, Labour and Welfare of Japan
- Grants-in-Aid for Scientific Research [26305030, 26460861] Funding Source: KAKEN
Creutzfeldt-Jakob disease (CJD) with a causative point mutation of valine to isoleucine at codon 180 (V180I) is one of the major types of genetic CJD (gCJD) in Japan. V180I gCJD is rarely accompanied by a family history, and its clinical characteristics include late-onset, long disease duration, and edematous cortical hyperintensity in diffusion, fluid attenuate inversion and T2-weighted MRI. We performed serial imaging with single-photon emission computed tomography (SPELT) and MRI in three V180I gCJD cases over long-term observation. All cases were characterized by progressive dementia, parkinsonism, and the absence of cerebellar signs or cortical visual dysfunction in their clinical courses. Moreover, during the end-stage, SPECT findings showed preserved regional cerebral blood flow (rCBF) in the occipital cortices, brainstem, and cerebellum. Similarly, no apparent atrophy or increased signal intensities were observed in MRI images of the occipital and cerebellar regions. In conclusion, we report a decrease in rCBF predominantly in the frontal and temporal cortices during the early stage, which became more widespread as the disease progressed. Importantly, rCBF was preserved in the occipital cortices, brainstem, and cerebellar regions until the end-stage, which may be distinct to V180I gCJD cases. (C) 2016 Elsevier B.V. All rights reserved.
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