期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 361, 期 -, 页码 213-219出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2016.01.013
关键词
Multiple sclerosis; Epstein-Barr virus; Human endogenous retroviruses; B-cell; CD20
资金
- Basque Country Foundation for Health Innovation and Research
- Bayer-Schering
- Biogen Idec
- Merck Seron
- Novartis
- UCB
- Almirall
- Teva
Multiple sclerosis is caused by a complex interaction between genetic predisposition and environmental factors. Epstein Barr virus (EBV) is an environmental risk factor that is strongly related to multiple sclerosis (MS), since EBV seropositivity is linked to a significant risk of developing MS. EBV may be involved in the pathogenesis of the disease and it is possibly a prerequisite for the development of MS. EBV infection persists in B-cells during the lifetime of the host and can modulate their function. In addition, MS patients might have a deficient capacity to eliminate latent EBV infection in the central nervous system and this would promote the accumulation of infected B cells. Several mechanisms of pathogenesis, including a direct and indirect function of infected B cells, have been postulated in inflammation and neurodegeneration. A relationship between EBV and human endogenous retroviruses in the pathogenesis of MS has also been reported. If EBV is important in the pathogenesis of MS, different therapeutic strategies seem possible for MS treatment. (C) 2016 Elsevier B.V. All rights reserved.
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