FNAIT pathogenesis determined by serial analysis of three subsequent pregnancies of a woman with severe fetal and neonatal alloimmune thrombocytopenia (FNAIT) with anti-HPA-4b and anti-HPA-5b alloantibodies in the first sibling

Review Hematology

Anti-human platelet antigen-5b antibodies and fetal and neonatal alloimmune thrombocytopenia; incidental association or cause and effect?

Julia Alm et al.

Summary: Most cases of FNAIT are caused by maternal anti-HPA-1a antibodies, while anti-HPA-5b antibodies are the second most common antibodies. However, there is no evidence supporting the idea that anti-HPA-5b antibodies cause severe thrombocytopenia or bleeding complications.

BRITISH JOURNAL OF HAEMATOLOGY (2022)

添加到收藏夹

Article Hematology

Clinical characteristics of human platelet antigen (HPA)-1a and HPA-5b alloimmunised pregnancies and the association between platelet HPA-5b antibodies and symptomatic fetal neonatal alloimmune thrombocytopenia

Thijs W. de Vos et al.

Summary: Fetal neonatal alloimmune thrombocytopenia (FNAIT) is a condition caused by maternal alloantibodies targeting human platelet antigens, which can result in severe bleeding in the unborn child. While anti-HPA-1a-mediated FNAIT tends to have a more severe clinical outcome, anti-HPA-5b may also be associated with severe neonatal bleeding symptoms. Further research, including a prospective study, is needed to fully understand the natural history of anti-HPA-5b mediated FNAIT.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

添加到收藏夹

Article Hematology