ESGO/ESTRO quality indicators for radiation therapy of cervical cancer

Article Oncology

Set-Up Errors, Organ Motion, Tumour Regression and its Implications on Internal Target Volume-Planning Target Volume During Cervical Cancer Radiotherapy: Results From a Prospective Study

U. Mahantshetty et al.

Summary: This study investigated the influence of uterocervical motions and organ filling on setup margins during cervical cancer radiotherapy. The results suggest the need for anisotropic margins for the cervix and uterine fundus.

CLINICAL ONCOLOGY (2022)

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Article Oncology

Impact of Vaginal Symptoms and Hormonal Replacement Therapy on Sexual Outcomes After Definitive Chemoradiotherapy in Patients With Locally Advanced Cervical Cancer: Results from the EMBRACE-I Study

Kathrin Kirchheiner et al.

Summary: This study evaluates the sexual outcomes of patients with locally advanced cervical cancer after chemoradiation therapy and image-guided adaptive brachytherapy. The results show that vaginal functioning problems are associated with pain and compromised sexual enjoyment. Further efforts for prevention and rehabilitation are needed.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

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Article Oncology

Severity and Persistency of Late Gastrointestinal Morbidity in Locally Advanced Cervical Cancer: Lessons Learned From EMBRACE-I and Implications for the Future

Sofia Spampinato et al.

Summary: This study aimed to evaluate the risk factors for gastrointestinal symptoms in patients with locally advanced cervical cancer after radiotherapy and image guided adaptive brachytherapy. The results showed that both treatment-related factors and patient-related factors were associated with GI symptoms.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

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Article Oncology

Dose-effect relationship between vaginal dose points and vaginal stenosis in cervical cancer: An EMBRACE-I sub-study

Henrike Westerveld et al.

Summary: This study evaluated the relationship between vaginal dose points and vaginal stenosis in patients with locally advanced cervical cancer. The results showed that higher doses to specific vaginal dose points were significantly associated with G >= 2 vaginal stenosis. Other risk factors included vaginal involvement, older age, shorter vaginal reference length, and the use of a specific applicator.

RADIOTHERAPY AND ONCOLOGY (2022)

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Article Oncology

Persistence of Late Substantial Patient-Reported Symptoms (LAPERS) After Radiochemotherapy Including Image Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer: A Report From the EMBRACE Study

Anders S. Vittrup et al.

Summary: This report describes the persistence of late substantial treatment-related patient-reported symptoms in survivors of locally advanced cervical cancer. A subgroup of patients with persistent symptoms was identified, emphasizing the importance of distinguishing between transient and persisting symptoms in the aftercare of LACC survivors. The majority of LAPERS events occurred in patients without corresponding severe physician-assessed morbidity.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Article Oncology

Dose-Volume Effects and Risk Factors for Late Diarrhea in Cervix Cancer Patients After Radiochemotherapy With Image Guided Adaptive Brachytherapy in the EMBRACE I Study

Nina B. K. Jensen et al.

Summary: The study evaluated patient- and treatment-related risk factors associated with late diarrhea after radiochemotherapy and image guided adaptive brachytherapy in locally advanced cervical cancer. Dose and volume effects were established for late diarrhea, with the importance of EBRT volumes as determinants of late toxicity emphasized.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Article Oncology

Importance of the ICRU bladder point dose on incidence and persistence of urinary frequency and incontinence in locally advanced cervical cancer: An EMBRACE analysis

Sofia Spampinato et al.

Summary: The study on locally advanced cervical cancer patients revealed that baseline morbidity and overweight/obesity are risk factors for urinary frequency and incontinence. Additionally, elderly patients are more prone to incontinence, while patients receiving conformal-radiotherapy are more likely to experience frequency.

RADIOTHERAPY AND ONCOLOGY (2021)

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News Item Oncology

WHO launches strategy to accelerate elimination of cervical cancer

Manjulika Das

LANCET ONCOLOGY (2021)

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Article Oncology

The European cancer burden in 2020: Incidence and mortality estimates for 40 countries and 25 major cancers

Tadeusz Dyba et al.

Summary: This article presents the incidence and mortality estimates for 25 major cancers across 40 individual countries within European areas and the EU-27 for the year 2020. The most common cancers are breast, colorectal, lung, and prostate cancers, which account for half the overall cancer burden in Europe. The estimates provide a basis for setting priorities in cancer-control measures across Europe.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Obstetrics & Gynecology

Cancer of the cervix uteri: 2021 update

Neerja Bhatla et al.

Summary: Since the publication of the 2018 FIGO Cancer Report, significant progress has been made in reducing the burden of cervical cancer globally, with initiatives such as the WHO's global strategy for cervical cancer elimination, HPV vaccination programs, and wider implementation of HPV testing. While these interventions will take time to show their impact, over half a million new cases of cervical cancer are still added each year.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2021)

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Article Oncology

Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: An EMBRACE analysis

Max Peters et al.

Summary: In the EMBRACE I study, risk factors for nodal failure in locally advanced cervical cancer patients were examined, with tumor width, nodal risk groups, local failure, and lower Hb-nadir identified as influencing factors. Elective PAO-irradiation was associated with decreased risk of PAO nodal failure.

RADIOTHERAPY AND ONCOLOGY (2021)

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Article Oncology

Risk factors and dose-effects for bladder fistula, bleeding and cystitis after radiotherapy with imaged-guided adaptive brachytherapy for cervical cancer: An EMBRACE analysis

Sofia Spampinato et al.

Summary: This study aimed to identify patient- and treatment-related risk factors for complications in locally advanced cervical cancer patients receiving radiotherapy and IGABT. The results showed that baseline urinary morbidity and overweight/obesity were significant risk factors for most endpoints, and a dose-effect was established with bladder D-2cm3 for fistula, bleeding, and cystitis.

RADIOTHERAPY AND ONCOLOGY (2021)

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Article Oncology

Nomogram Predicting Overall Survival in Patients With Locally Advanced Cervical Cancer Treated With Radiochemotherapy Including Image-Guided Brachytherapy: A Retro-EMBRACE Study

Alina Emiliana Sturdza et al.

Summary: This study developed a nomogram for predicting overall survival in patients with locally advanced cervical cancer based on data from 720 patients. The nomogram included factors such as age, tumor characteristics, and treatment regimens, and showed promising calibration and discrimination in predicting 60-month survival.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

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Article Oncology

MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study

Richard Pötter et al.

LANCET ONCOLOGY (2021)

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Article Oncology

Late Toxicity After Adjuvant Conventional Radiation Versus Image-Guided Intensity-Modulated Radiotherapy for Cervical Cancer (PARCER): A Randomized Controlled Trial

Supriya Chopra et al.

Summary: The PARCER study compared late toxicity after IG-IMRT with 3D-CRT in cervical cancer patients undergoing postoperative radiation, finding that IG-IMRT resulted in reduced gastrointestinal toxicity and improved patients' quality of life. However, there was no significant difference in disease outcomes between the two treatment methods.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Oncology

Comparison of Library of Plans with two daily adaptive strategies for whole bladder radiotherapy

Duncan den Boer et al.

Summary: This study compared the effectiveness of using LoP with two MRgRT strategies for whole bladder treatments. The results showed that MRgRT(15min) performed better than LoP and MRgRT(30min), indicating the need for a 15 min daily adaptive radiotherapy workflow to potentially benefit from replanning.

PHYSICS & IMAGING IN RADIATION ONCOLOGY (2021)

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Article Oncology

Quantitative and qualitative application of clinical drawings for image-guided brachytherapy in cervical cancer patients

Umesh Mahantshetty et al.

Summary: This study aimed to use modified clinical drawings to understand patterns of tumor regression in cervical cancer patients, as well as the correlation between initial GTVD and final CTV-T-HR. Meticulous mapping of tumor volumes can provide useful insights for CTV-T-HR volume during brachytherapy.

JOURNAL OF CONTEMPORARY BRACHYTHERAPY (2021)

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Article Oncology

Late, Persistent, Substantial, Treatment-Related Symptoms After Radiation Therapy (LAPERS): A New Method for Longitudinal Analysis of Late Morbidity-Applied in the EMBRACE Study

Kathrin Kirchheiner et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

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Article Oncology

A Phase II Trial of Stereotactic Ablative Radiation Therapy as a Boost for Locally Advanced Cervical Cancer

Kevin Albuquerque et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

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Article Oncology

European Society of Gynaecological Oncology quality indicators for surgical treatment of cervical cancer

David Cibula et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2020)

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Article Oncology

Ring Versus Ovoids and Intracavitary Versus Intracavitary-Interstitial Applicators in Cervical Cancer Brachytherapy: Results From the EMBRACE I Study

Monica Serban et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

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Article Oncology

Improvement in Patient-Reported Outcomes With Intensity-Modulated Radiotherapy (RT) Compared With Standard RT: A Report From the NRG Oncology RTOG 1203 Study

Anamaria R. Yeung et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Oncology

Hypnosedation for endocavitary uterovaginal applications: A pilot study

Manon Kissel et al.

BRACHYTHERAPY (2020)

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Article Oncology

Comprehensive analysis of patient outcome after local recurrence of locally advanced cervical cancer treated with concomitant chemoradiation and image-guided adaptive brachytherapy

F. Mignot et al.

GYNECOLOGIC ONCOLOGY (2020)

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Article Public, Environmental & Occupational Health

Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis

Marc Arbyn et al.

LANCET GLOBAL HEALTH (2020)

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Article Medicine, General & Internal

Interaction between the Number of Chemotherapy Cycles and Brachytherapy Dose/Volume Parameters in Locally Advanced Cervical Cancer Patients

Alexandre Escande et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Oncology

Education and training for image-guided adaptive brachytherapy for cervix cancer-The (GEC)-ESTRO/EMBRACE perspective

Li-Tee Tan et al.

BRACHYTHERAPY (2020)

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Article Oncology

Implementing an online radiotherapy quality assurance programme with supporting continuous medical education - report from the EMBRACE-II evaluation of cervix cancer IMRT contouring

Simon L. Duke et al.

RADIOTHERAPY AND ONCOLOGY (2020)

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Article Oncology

Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer

Kari Tanderup et al.

SEMINARS IN RADIATION ONCOLOGY (2020)

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Article Oncology

Surgical versus clinical staging prior to primary chemoradiation in patients with cervical cancer FIGO stages IIB-IVA: oncologic results of a prospective randomized international multicenter (Uterus-11) intergroup study

Simone Marnitz et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2020)

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Article Medicine, General & Internal

Prognostic Significance of Tumor Regression Rate during Concurrent Chemoradiotherapy in Locally Advanced Cervix Cancer: Analysis by Radiation Phase and Histologic Type

Jun-Hyeok Kang et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Letter Oncology

Brachytherapy Issues and Priorities in the Context of the Coronavirus Disease 2019 (COVID-19) Outbreak

Cyrus Chargari et al.

ADVANCES IN RADIATION ONCOLOGY (2020)

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Article Oncology

Importance of Technique, Target Selection, Contouring, Dose Prescription, and Dose-Planning in External Beam Radiation Therapy for Cervical Cancer: Evolution of Practice From EMBRACE-I to II

Thomas Berger et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2019)

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Meeting Abstract Oncology

Results from neoadjuvant chemotherapy followed by surgery compared to chemoradiation for stage Ib2-IIb cervical cancer, EORTC 55994.

Gemma Kenter et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Oncology

Importance of training in external beam treatment planning for locally advanced cervix cancer: Report from the EMBRACE II dummy run

Yvette Seppenwoolde et al.

RADIOTHERAPY AND ONCOLOGY (2019)

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Article Oncology

Brachytherapy: An overview for clinicians

Cyrus Chargari et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2019)

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Article Multidisciplinary Sciences

Effect of time interval from diagnosis to treatment for cervical cancer on survival: A nationwide cohort study

Chao-Ping Chen et al.

PLOS ONE (2019)

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Article Oncology

Vienna-II ring applicator for distal parametrial/pelvic wall disease in cervical cancer brachytherapy: An experience from two institutions: Clinical feasibility and outcome

Umesh Mahantshetty et al.

RADIOTHERAPY AND ONCOLOGY (2019)

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Article Oncology

Brachytherapy: A critical component of primary radiation therapy for cervical cancer: From the Society of Gynecologic Oncology (SGO) and the American Brachytherapy Society (ABS)

Christine H. Holschneider et al.

BRACHYTHERAPY (2019)

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Review Oncology

Quality indicators for the management of endometrial, cervical and ovarian cancer

Anne-Sophie Bonte et al.

EJSO (2019)

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Article Medicine, General & Internal

Total Reference Air Kerma is Associated with Late Bowel Morbidity in Locally Advanced Cervical Cancer Patients Treated with Image-Guided Adaptive Brachytherapy

Sophie Bockel et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Article Oncology

Efficacy and Toxicity of IMRT-Based Simultaneous Integrated Boost for the Definitive Management of Positive Lymph Nodes in Patients with Cervical Cancer

Yun-Zhi Dang et al.

JOURNAL OF CANCER (2019)

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Article Oncology

Dose-volume effects in pathologic lymph nodes in locally advanced cervical cancer

Warren Bacorro et al.

GYNECOLOGIC ONCOLOGY (2018)

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Article Oncology

The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology Guidelines for the Management of Patients With Cervical Cancer

David Cibula et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2018)

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Article Oncology

Risk of Late Urinary Complications Following Image Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer: Refining Bladder Dose-Volume Parameters

Elena Manea et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2018)

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Article Oncology

Tumor Shrinkage During Chemoradiation in Locally Advanced Cervical Cancer Patients: Prognostic Significance, and Impact for Image-Guided Adaptive Brachytherapy

Antoine Schernberg et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2018)

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Article Oncology

Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Concomitant Chemotherapy and Radiotherapy in Patients With Stage IB2, IIA, or IIB Squamous Cervical Cancer: A Randomized Controlled Trial

Sudeep Gupta et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Oncology

Patient-Reported Toxicity During Pelvic Intensity-Modulated Radiation Therapy: NRG Oncology-RTOG 1203

Ann H. Klopp et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

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Article Oncology

Quality indicators for cervical cancer care in Japan

Tomone Watanabe et al.

JOURNAL OF GYNECOLOGIC ONCOLOGY (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

CBCT-guided evolutive library for cervical adaptive IMRT

Bastien Rigaud et al.

MEDICAL PHYSICS (2018)

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Article Oncology

The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology guidelines for the management of patients with cervical cancer

David Cibula et al.

RADIOTHERAPY AND ONCOLOGY (2018)

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Article Oncology

Bowel morbidity following radiochemotherapy and image-guided adaptive brachytherapy for cervical cancer: Physician- and patient reported outcome from the EMBRACE study

Nina Boje Kibsgaard Jensen et al.

RADIOTHERAPY AND ONCOLOGY (2018)

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Article Pathology

The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology Guidelines for the Management of Patients with Cervical Cancer

David Cibula et al.

VIRCHOWS ARCHIV (2018)

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Review Oncology

The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies

Richard Potter et al.

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY (2018)

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Review Oncology

Concurrent chemoradiotherapy vs. radiotherapy alone in locally advanced cervix cancer: A systematic review and meta-analysis

Niloy Ranjan Datta et al.

GYNECOLOGIC ONCOLOGY (2017)

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Article Oncology

Contribution of image-guided adaptive brachytherapy to pelvic nodes treatment in locally advanced cervical cancer

Warren Bacorro et al.

BRACHYTHERAPY (2017)

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Article Oncology

Tumor dose-volume response in image-guided adaptive brachytherapy for cervical cancer: A meta-regression analysis

Renaud Mazeron et al.

BRACHYTHERAPY (2016)

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Article Oncology

Image-guided adaptive brachytherapy in cervical cancer: Patterns of relapse by brachytherapy planning parameters

Cyrus Chargari et al.

BRACHYTHERAPY (2016)

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Article Oncology

Combining transrectal ultrasound and CT for image-guided adaptive brachytherapy of cervical cancer: Proof of concept

Nicole Nesvacil et al.

BRACHYTHERAPY (2016)

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Article Oncology

45 or 50 Gy, Which is the Optimal Radiotherapy Pelvic Dose in Locally Advanced Cervical Cancer in the Perspective of Reaching Magnetic Resonance Image-guided Adaptive Brachytherapy Planning Aims?

R. Mazeron et al.

CLINICAL ONCOLOGY (2016)

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Article Oncology

Health-Related Quality of Life in Locally Advanced Cervical Cancer Patients After Definitive Chemoradiation Therapy Including Image Guided Adaptive Brachytherapy: An Analysis From the EMBRACE Study

Kathrin Kirchheiner et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2016)

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Article Oncology