Antioxidant potentialities and gastroprotective effect of Reichardia picroides extracts on Ethanol/HCl induced gastric ulcer rats

The goal of this study was to determine for the first time the polyphenol content, antioxidant, and gastroprotective properties of the roots and leaves of Reichardia picroides. TPC considerably varied as a function of organs and solvent nature and ranged from 50 to 284.80 mg GAE/g DW. Leaves exhibited the highest amount of phenolics by using acetone 70%, the same tendency was observed for antioxidant activity. Besides, in vivo gastro-protective effects following HCl/EtOH-induced ulcer models displayed that roots extract at a high dose (500 mg) seemed to be the best performing extract with a decrease of ulceration index (UI) and an increase in the percentage of protection (PP), SOD, CAT, and GPX activities. All these data have been proved with principal component analysis (PCA). Overall, the results indicated that R. picroides could be considered a valuable source of natural compounds, which are beneficial for human health.

Automated summary

The aim of this study was to assess the polyphenol content, antioxidant, and gastroprotective properties of Reichardia picroides roots and leaves. The total polyphenol content varied significantly depending on the organ and solvent used, ranging from 50 to 284.80 mg GAE/g DW. The leaves showed the highest phenolic content when extracted with 70% acetone, which also correlated with the highest antioxidant activity. Moreover, in vivo experiments using HCl/EtOH-induced ulcer models demonstrated that the root extract at a high dose (500 mg) exhibited the best gastroprotective effects, reducing the ulceration index (UI) and increasing the percentage of protection (PP), SOD, CAT, and GPX activities. These findings were further supported by principal component analysis (PCA). Overall, the results highlight Reichardia picroides as a valuable natural source of compounds with potential benefits for human health.