Temporal patterns of childhood cancer survival 1991 to 2016: A nationwide register-study based on data from the German Childhood Cancer Registry

Article Oncology

Incidence and survival of childhood central nervous system tumors in Denmark, 1997-2019

Anne Sophie Lind Helligsoe et al.

Summary: Incidence rates of childhood CNS tumors in Denmark remain stable but among the highest in the world. Despite improved survival rates in recent years for children aged 0-4 years, some subtypes still have a poor prognosis.

CANCER MEDICINE (2022)

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Article Oncology

Long-Term Clinical Outcome and Prognostic Factors of Children and Adolescents with Localized Rhabdomyosarcoma Treated on the CWS-2002P Protocol

Ewa Koscielniak et al.

Summary: The CWS-2002P study focused on adapting therapy burden to risk profile in pediatric oncology to achieve optimal outcomes with minimal toxicities. The risk stratification system effectively predicted long-term results, regardless of chemotherapy reduction or intensification. Maintenance therapy appeared to impact prognosis, suggesting the need for further investigation in a well-controlled prospective trial.

CANCERS (2022)

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Article Oncology

Long-term survival and cure fraction estimates for childhood cancer in Europe (EUROCARE-6): results from a population-based study

Laura Botta et al.

Summary: The EUROCARE-6 study analyzed data from 31 European countries and found disparities in childhood cancer survival rates among these countries. While the overall survival rates have improved for most cancer types, there are still differences in survival rates for specific cancers. The study also estimated the cure fraction for different childhood cancers and projected survival rates for the next 15 years.

LANCET ONCOLOGY (2022)

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Letter Hematology

Survival in Children Below the Age of 15 Years With Leukemia: Temporal Patterns in Eastern and Western Germany Since German Reunification

Maike Wellbrock et al.

HEMASPHERE (2022)

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Article Psychiatry

Psychiatric disorders in childhood cancer survivors in Denmark, Finland, and Sweden: a register-based cohort study from the SALiCCS research programme

Line Elmerdahl Frederiksen et al.

Summary: Childhood cancer survivors have a higher long-term risk of psychiatric disorders compared to their siblings and the general population. They are more likely to have recurrent psychiatric hospital contacts and contacts for different psychiatric disorders.

LANCET PSYCHIATRY (2022)

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Article Health Care Sciences & Services

Employment status and occupational positions of childhood cancer survivors from Denmark, Finland and Sweden: A Nordic register-based cohort study from the SALiCCS research programme

Line Elmerdahl Frederiksen et al.

Summary: Childhood cancer survivors experience higher rates of health-related unemployment, especially those diagnosed with central nervous system tumors and those diagnosed before the age of 15. Comprehensive survivorship care and interventions are needed to assist these survivors in obtaining and maintaining suitable employment.

LANCET REGIONAL HEALTH-EUROPE (2022)

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Article Oncology

Childhood cancer: Survival, treatment modalities, late effects and improvements over time

Friederike Erdmann et al.

Summary: Pediatric oncologists have improved in organization and clinical trial participation, with chemotherapy being the main treatment element and high survival rates achieved in most European and North American countries. Survivors of childhood cancer face long-term risks of somatic and mental health issues, as well as social and economic difficulties.

CANCER EPIDEMIOLOGY (2021)

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Review Pediatrics

Advances in the classification and treatment of pediatric brain tumors

Jason Fangusaro et al.

Summary: Recent genetic and molecular findings have significantly impacted the diagnosis and treatment of pediatric central nervous system tumors, including identifying aberrations in the mitogen-activated protein kinase pathway in low-grade gliomas, recurrent histone mutations in certain gliomas, and molecular subgroups in medulloblastoma. These advancements have not only improved diagnostic accuracy, but also paved the way for new targeted therapies with the potential for better patient outcomes.

CURRENT OPINION IN PEDIATRICS (2021)

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Article Oncology

Significant improvement in survival of advanced stage childhood and young adolescent cancer in the Netherlands since the 1990s

Maya Schulpen et al.

Summary: Since the 1990s, significant progress has been made in the prognosis of childhood and young adolescent cancer in the Netherlands, with notable improvements in survival rates, especially for patients with advanced stages. Although the prognosis for some types of cancer remains modest, the overall mortality rates have been decreasing steadily.

EUROPEAN JOURNAL OF CANCER (2021)

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Article Pediatrics

Risk factors for cancer in childhood and adolescence

M. Stanulla et al.

Summary: The causes of cancer in childhood and adolescence are largely unknown, with known risk factors explaining only a small proportion of cases. Genetic analyses offer promising approaches to understanding the etiology, identifying rare germline variants associated with increased cancer risk in this age group.

MONATSSCHRIFT KINDERHEILKUNDE (2021)

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Article Pediatrics

Doubling Recruitment of Pediatric Low-grade Glioma within Two Decades does not change Outcome - Report from the German LGG Studies

Astrid Katharina Gnekow et al.

KLINISCHE PADIATRIE (2021)

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Article Oncology

Epidemiology of cancer in children and adolescents

Maike Wellbrock et al.

Summary: Childhood and adolescent cancer is rare, with incidence rates varying across age groups and higher in boys. Leukaemia is the most common type, with diverse causes including known factors like radiation exposure and genetic syndromes, as well as other potential factors such as environmental pollutants and lifestyle choices.

ONKOLOGE (2021)

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Article Oncology

Neuroblastoma Screening at 1 Year of Age: The Final Results of a Controlled Trial

Frank Berthold et al.

Summary: The study investigated the outcomes of neuroblastoma screening 20 years after cessation of the program, showing that the screening did not reduce stage 4 disease incidence or mortality and was affected by overdiagnosis. Screening-detected stage 4 cases had better biological characteristics but did not change the recommendation to close the catecholamine-based neuroblastoma screening program.

JNCI CANCER SPECTRUM (2021)

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Article Oncology

Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results of the AML SCT-BFM 2007 trial

Martin G. Sauer et al.

LEUKEMIA (2020)

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Article Oncology

Childhood cancer incidence and survival trends in Estonia (1970-2016): a nationwide population-based study

Keiu Paapsi et al.

BMC CANCER (2020)

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Letter Oncology

Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial

Andishe Attarbaschi et al.

LEUKEMIA (2020)

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Article Oncology

Childhood cancer mortality trends in Europe, 1990-2017, with focus on geographic differences

Paola Bertuccio et al.

CANCER EPIDEMIOLOGY (2020)

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Article Oncology

The world cancer patient population (WCPP): An updated standard for international comparisons of population-based survival

Adalberto Miranda-Filho et al.

CANCER EPIDEMIOLOGY (2020)

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Review Oncology

Surviving childhood cancer: a systematic review of studies on risk and determinants of adverse socioeconomic outcomes

Line Elmerdahl Frederiksen et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Article Oncology

Outcome and Patterns of Relapse in Childhood Parameningeal Rhabdomyosarcoma Treated With Proton Beam Therapy

Jerome Doyen et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2019)

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Article Hematology

Results of CoALL 07-03 study childhood ALL based on combined risk assessment by in vivo and in vitro pharmacosensitivity

Franziska Schramm et al.

BLOOD ADVANCES (2019)

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Article Oncology

Long-term outcomes of the GPOH NB97 trial for children with high-risk neuroblastoma comparing high-dose chemotherapy with autologous stem cell transplantation and oral chemotherapy as consolidation

Frank Berthold et al.

BRITISH JOURNAL OF CANCER (2018)

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Article Oncology

Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012

Mareike Rasche et al.

LEUKEMIA (2018)

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Article Oncology

Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991-2010 (Automated Childhood Cancer Information System): a population-based study

Eva Steliarova-Foucher et al.

LANCET ONCOLOGY (2018)

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Review Oncology

Survival After Childhood Cancer-Social Inequalities in High-Income Countries

Hanna Mogensen et al.

FRONTIERS IN ONCOLOGY (2018)

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Article Oncology

Childhood cancer survival in Switzerland (1976-2013): Time-trends and predictors

Matthias Schindler et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

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Article Oncology

International incidence of childhood cancer, 2001-10: a population-based registry study

Eva Steliarova-Foucher et al.

LANCET ONCOLOGY (2017)

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Article Pediatrics

Incidence, Survival, and Treatment of Localized and Metastatic Neuroblastoma in Germany 1979-2015

Frank Berthold et al.

PEDIATRIC DRUGS (2017)

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Article Hematology

Worldwide comparison of survival from childhood leukaemia for 1995-2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries

Audrey Bonaventure et al.

LANCET HAEMATOLOGY (2017)

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Article Oncology

Complete surgical resection improves outcome in INRG high-risk patients with localized neuroblastoma older than 18 months

Janina Fischer et al.

BMC CANCER (2017)

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Review Medicine, Research & Experimental

Environmental Exposure and Risk of Childhood Leukemia: An Overview

Joachim Schuz et al.

ARCHIVES OF MEDICAL RESEARCH (2016)

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Article Oncology

Trends in incidence, survival and mortality of childhood and adolescent cancer in Austria, 1994-2011

Henrike E. Karim-Kos et al.

CANCER EPIDEMIOLOGY (2016)

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Review Oncology

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration

Ching-Hon Pui et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

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Article Pediatrics

Remaining Challenges in Childhood Cancer and Newer Targeted Therapeutics

Malcolm A. Smith et al.

PEDIATRIC CLINICS OF NORTH AMERICA (2015)

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Article Pediatrics

Genetic and Nongenetic Risk Factors for Childhood Cancer

Logan G. Spector et al.

PEDIATRIC CLINICS OF NORTH AMERICA (2015)

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Editorial Material Oncology

Declining Childhood and Adolescent Cancer Mortality Great Progress but Still Much to Be Done

Kathy Pritchard-Jones et al.

CANCER (2014)

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Article Oncology

Childhood cancer survival in France, 2000-2008

Brigitte Lacour et al.

EUROPEAN JOURNAL OF CANCER PREVENTION (2014)

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Article Oncology

Childhood cancer survival in Finland (1953-2010): A nation-wide population-based study

M. Madanat-Harjuoja et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

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Article Oncology

Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5-a population-based study

Gemma Gatta et al.

LANCET ONCOLOGY (2014)

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Article Oncology

Management of Bone Tumours in Paediatric Oncology

T. Boelling et al.

CLINICAL ONCOLOGY (2013)

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Article Pediatrics

Development of a Curative Treatment within the AML-BFM Studies

U. Creutzig et al.

KLINISCHE PADIATRIE (2013)

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Article Medicine, General & Internal

Health services for children in western Europe

Ingrid Wolfe et al.

LANCET (2013)

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Article Oncology

Effective childhood cancer treatment: The impact of large scale clinical trials in Germany and Austria

C. Rossig et al.

PEDIATRIC BLOOD & CANCER (2013)

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Article Oncology

Survival from childhood acute lymphoblastic leukaemia: the impact of social inequality in the United Kingdom

T. J. Lightfoot et al.

EUROPEAN JOURNAL OF CANCER (2012)

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Article Oncology

Survival from childhood cancer in northern England, 1968-2005

N. O. Basta et al.

BRITISH JOURNAL OF CANCER (2011)

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Review Oncology

Disparities in Cancer Outcomes: Lessons Learned From Children With Cancer

Smita Bhatia

PEDIATRIC BLOOD & CANCER (2011)

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Article Oncology

Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia

K. Schmiegelow et al.

LEUKEMIA (2010)

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Article Oncology

Consequent and intensified relapse therapy improved survival in pediatric AML: results of relapse treatment in 379 patients of three consecutive AML-BFM trials

A. Sander et al.

LEUKEMIA (2010)

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Article Hematology

Methods for Equivalence and Noninferiority Testing

Gisela Tunes da Silva et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2009)

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Article Oncology

Survival of European children and young adults with cancer diagnosed 1995-2002

Gemma Gatta et al.

EUROPEAN JOURNAL OF CANCER (2009)

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Article Hematology

Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival:: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95

Anja Moericke et al.

BLOOD (2008)

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Review Oncology

Childhood cancer survival in France, 1990-1999

Emmanuel Desandes et al.

EUROPEAN JOURNAL OF CANCER (2008)

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Article Hematology

History of the treatment of childhood ALL: A paradigm for cancer cure

JV Simone

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2006)

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Article Medicine, General & Internal

Treatment of early childhood medulloblastoma by postoperative chemotherapy alone

S Rutkowski et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Article Hematology

The impact of the methotrexate administration schedule and dose in the treatment of children and adolescents with B-cell neoplasms: a report of the BFM Group Study NHL-BFM95

W Woessmann et al.

BLOOD (2005)

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Temporal patterns of childhood cancer survival 1991 to 2016: A nationwide register-study based on data from the German Childhood Cancer Registry

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