期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 233, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.123489
关键词
Nisin; Tannic acid; Loaded chitosan particle
This study investigated the effect of adding tannic acid to chitosan matrices encapsulating nisin. Composite materials were prepared using a mild procedure, and the particles were characterized by various methods. The addition of tannic acid enhanced the release of nisin and provided antioxidant activity to the composites. Furthermore, the composites showed synergistic effects against bacteria, especially gram-negative species.
This study investigates the effect of addition of tannic acid on nisin encapsulated in chitosan matrices. Composite materials were prepared using a mild, environmentally friendly procedure, ionotropic gelation of chitosan by sodium tripolyphosphate in the presence of nisin (N) at different concentrations. In two parallel sets of prepa-rations, tannic acid (TA) was added at 10:1 and 5:1 N:TA, respectively. The obtained particles were characterized by FTIR, SEM, size, zeta potential, encapsulation efficiency, loading capacity, and ratio of residual free amino groups. The kinetics of nisin release from the particles was studied to assess the role of TA as a potential modulator thereof. Its addition resulted in enhanced release, higher at lower N:TA ratio. An additional benefit was that TA, a strong antioxidant, imparted antioxidant activity to the composites. Antimicrobial turbidimetric tests were performed against one gram-positive bacterium (Staphylococcus aureus) and two gram-negative bac-teria (Escherichia coli and Pseudomonas aeruginosa), all relevant for the food, pharmaceutical, and cosmetic in-dustries. All the composites showed synergistic effects against all the bacteria tested. The positive coaction was stronger against the gram-negative species. This is remarkable since nisin by itself has not known activity against them.
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