期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 238, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.124114
关键词
Longan polysaccharide; Structural characterization; Simulated digestion; Dendritic cells; Immunomodulation
An active polysaccharide (LP) from longan was purified and characterized. LP consists of galactose and glucose in a molar ratio of 1.5:98.5, with a molecular weight of 4.67 x 107 g/mol. The main backbone of LP is T-alpha-D-Glcp-[(1-* 6)-alpha-D-Glcp-(1-* 6)-alpha-D-Glcp]n. After simulated gastrointestinal digestion, the molecular weight distribution, monosaccharide composition, and major glycosidic bonds of LP were not significantly changed. LP and digested LP (DLP) reduced phagocytosis and promoted IL-10 and IL-12 secretion of dendritic cells. Additionally, there was no significant difference in the effects of LP and DLP on activating dendritic cells. This study helps to illuminate the potential mode of immunomodulatory action of longan polysaccharides in vivo.
An active polysaccharide (LP) from longan was purified and characterized. LP consisted of galactose and glucose in a molar ratio of 1.5: 98.5, with a molecular weight of 4.67 x 107 g/mol. The main backbone of LP was T-alpha-D-Glcp-[(1-* 6)-alpha-D-Glcp-(1-* 6)-alpha-D-Glcp]n. After simulated gastrointestinal digestion, the molecular weight distribution, monosaccharide composition, and major glycosidic bonds of LP were not significantly changed. LP and digested LP (DLP) reduced phagocytosis and promoted IL-10 and IL-12 secretion of dendritic cells. In addition, the effects of LP and DLP on activating dendritic cells showed no significant difference. This study helps to illuminate the potential mode of immunomodulatory action of longan polysaccharides in vivo.
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