The transcription factor RUNX1 affects the maturation of porcine oocytes via the BMP15/TGF-? signaling pathway

Article Veterinary Sciences

In vitro maturation using αMEM with reduced NaCl enhances maturation and developmental competence of pig oocytes after somatic cell nuclear transfer

Yongjin Lee et al.

Summary: Using a medium with reduced NaCl enhances cytoplasmic maturation and embryonic development of pig oocytes.

JOURNAL OF VETERINARY SCIENCE (2022)

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Article Endocrinology & Metabolism

Novel bone morphogenetic protein 15 (BMP15) gene variants implicated in premature ovarian insufficiency

Fatemeh Afkhami et al.

Summary: This study identified two BMP15 gene mutations associated with idiopathic premature ovarian insufficiency and conducted bioinformatics analysis to investigate their effects on protein function. The findings contribute to a better understanding of the disease pathogenesis.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2022)

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Article Genetics & Heredity

Supplementation of EGF, IGF-1, and Connexin 37 in IVM Medium Significantly Improved the Maturation of Bovine Oocytes and Vitrification of Their IVF Blastocysts

Sha Yang et al.

Summary: The addition of EGF, IGF-1, and Cx37 in the in vitro maturation (IVM) of bovine oocytes significantly improves their quality and developmental ability by increasing transzonal projection (TZP), mitochondrial function, and glutathione (GSH) level.

GENES (2022)

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Review Cell Biology

TGF-β Superfamily Signaling in the Eye: Implications for Ocular Pathologies

Soumaya Hachana et al.

Summary: The TGF-beta signaling pathway plays a crucial role in eye development and pathology. Defective TGF-beta signaling has been associated with eye pathologies, and modulating this pathway has potential as a treatment option for eye diseases.

CELLS (2022)

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Article Toxicology

Bovine In Vitro Oocyte Maturation and Embryo Production Used as a Model for Testing Endocrine Disrupting Chemicals Eliciting Female Reproductive Toxicity With Diethylstilbestrol as a Showcase Compound

K. Asimaki et al.

Summary: Endocrine disrupting chemicals (EDCs) can have adverse effects on women's reproductive health. Current screening methods lack tests to assess the effects of EDCs on oocyte maturation and embryo development. This study describes a screening method using bovine models to evaluate the impact of EDCs on oocyte maturation and early embryo development.

FRONTIERS IN TOXICOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Genome-wide identification of enhancers and transcription factors regulating the myogenic differentiation of bovine satellite cells

Pengcheng Lyu et al.

Summary: Tens of thousands of H3K27ac-marked active enhancers have been identified from bovine satellite cells before or during differentiation. These enhancers contain binding sites not only for transcription factors whose role in satellite cell differentiation is well known but also for transcription factors whose role in satellite cell differentiation is unknown. These enhancers and transcription factors are valuable resources for understanding the complex mechanism that mediates gene expression during satellite cell differentiation.

BMC GENOMICS (2021)

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Article Biochemistry & Molecular Biology

The Role of MAPK3/1 and AKT in the Acquisition of High Meiotic and Developmental Competence of Porcine Oocytes Cultured In Vitro in FLI Medium

Radek Prochazka et al.

Summary: Culturing porcine oocytes in a medium containing FGF2, LIF and IGF1 (FLI) significantly enhances their developmental potential. Analyzing the time course of MAPK3/1 and AKT activation, as well as gene expression controlled by these kinases, suggests that both MAPK3/1 and AKT play crucial roles in improving oocyte quality in FLI medium.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Immunology

RUNX1 Regulates a Transcription Program That Affects the Dynamics of Cell Cycle Entry of Naive Resting B Cells

Inesa Thomsen et al.

Summary: RUNX1 regulates a gene expression program in mouse B cells, affecting cell cycle dynamics in response to BCR stimulation. It interacts with SRCAP to recruit it to the promoter and enhancer regions of the Ccnd2 gene. Knockout of Runx1 leads to increased binding of BRG1 at the Ccnd2 and Rbpj promoters after BCR stimulation, resulting in hyperresponsiveness of B cells and potential involvement in regulating B cell tolerance.

JOURNAL OF IMMUNOLOGY (2021)

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Article Agriculture, Dairy & Animal Science

Expression Profiles of the Progesterone Receptor, Cyclooxygenase-2, Growth Differentiation Factor 9, and Bone Morphogenetic Protein 15 Transcripts in the Canine Oviducts during the Oestrous Cycle

Jaime Palomino et al.

Summary: The gene expression in canine oviductal cells is influenced by the oestrous cycle, with key genes showing differential expression at different stages, highlighting the importance of oestrous cycle regulation for successful reproduction in dogs.

ANIMALS (2021)

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Article Food Science & Technology

Grape Seed Proanthocyanidin Ameliorates FB1-Induced Meiotic Defects in Porcine Oocytes

Wenhui Li et al.

Summary: The study demonstrated that 200 μM GSP cotreatment effectively alleviated the toxic effects of FB1 exposure, promoting first polar body extrusion and improving subsequent cleavage and blastocyst development rates.

TOXINS (2021)

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Article Biochemistry & Molecular Biology

SMAD4 Feedback Activates the Canonical TGF-β Family Signaling Pathways

Lu Liu et al.

Summary: The study illustrates a novel mechanism in which SMAD4, as the only Co-SMAD, positively regulates the canonical TGF-beta family signaling pathways in granulosa cells (GCs) by interacting with the core promoters of upstream receptors through the recruitment of three coactivators (c-JUN, CREB1, and SP1). Different interaction modes between SMAD4 and coactivators were identified through reciprocal ChIP assays, expanding the understanding of the feedback regulation modes of TGF-beta family signaling pathways in ovarian GCs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Geriatrics & Gerontology

TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration

Wen Luo et al.

Summary: TMEM182 is specifically expressed in skeletal muscle and adipose tissue, regulated transcriptionally by MyoD1. Functionally, TMEM182 inhibits myoblast differentiation and fusion. In vivo studies show that TMEM182 induces muscle fibre atrophy and delays muscle regeneration, while TMEM182 knockout results in increased body weight, muscle mass, and accelerated skeletal muscle regeneration. Moreover, TMEM182 interacts with ITGB1 to modulate ITGB1 activation and downstream signaling pathways during myogenesis.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

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Article Agriculture, Dairy & Animal Science