期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 241, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.124548
关键词
Multimeric G-quadruplex; Telomere; Triazole; Breast cancer; Selective
This study proposed a strategy to design small-molecule ligands with selective binding to multimeric G-quadruplexes (G4s), and synthesized a library of multi-aryl compounds by attaching triazole rings to the quinoxaline skeleton. Among them, QTR-3 was identified as the most promising selective ligand that may bind at the G4-G4 interface, thereby stabilizing multimeric G4s and inducing DNA damage in the telomeric region, leading to cell cycle arrest and apoptosis. Importantly, QTR-3 exhibited more significant inhibition on breast cancer cells compared to normal mammary cells.
The telomeric 3 '-overhang had potential to form into higher-order structures termed multimeric G-quadruplexes (G4s), which may mainly exist in telomeres, representing an attractive drug target for development of anticancer agents with few side effects. However, only a few molecules that selectively bind to multimeric G4s have been found by random screening, which means a lot of room for improvement. In this study, we raised a feasible strategy to design small-molecule ligands with possible selectivity to multimeric G4s, and then synthesized a focused library of multi-aryl compounds by attaching triazole rings to the quinoxaline skeleton. Among them, QTR-3 was identified as the most promising selective ligand that may bind at the G4-G4 interface, which accordingly stabilized multimeric G4s and induced DNA damage in telomeric region, thereby leading to cell cycle arrest and apoptosis. Notably, QTR-3 showed more significant inhibition on breast cancer cells against normal mammary cells.
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