4.7 Article

Anticonvulsant effect of quercetin in pentylenetetrazole (PTZ)-induced seizures in male mice: The role of anti-neuroinflammatory and anti-oxidative stress

期刊

INTERNATIONAL IMMUNOPHARMACOLOGY
卷 116, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.intimp.2023.109772

关键词

Quercetin; Seizures; Inflammation; Oxidative stress; Pentylenetetrazole

向作者/读者索取更多资源

This study aimed to evaluate the effect of quercetin on PTZ-induced seizures in mice and focus on its potential anti-neuroinflammatory and anti-oxidative stress properties. The results showed that quercetin increased the seizure threshold, enhanced total antioxidant capacity, and reduced levels of malondialdehyde as well as the expression of inflammatory genes in the prefrontal cortex.
Background: Epilepsy is one of the major neurological disorders. The inflammatory process and oxidative stress are closely related to seizure progression. Quercetin is a flavonoid with anti-inflammatory and antioxidant properties as well as neuroprotective effects. We aimed to evaluate the effect of quercetin on pentylenetetrazole(PTZ-) induced seizures in male mice focusing on its possible anti-neuroinflammatory and anti-oxidative stress. Methods: In this study, 50 male NMRI mice were divided into five groups (n = 10) and given the following treatments: normal saline, quercetin at doses of 10, 20, and 40 mg/kg, and diazepam at a dose of 10 mg/kg. In order to induce seizures, PTZ was administered intravenously. Drugs were administered intravenously 60 min before the seizure induction. The seizure threshold was measured, and finally, malondialdehyde (MDA), total antioxidant capacity (TAC), and the gene expression of IL-1 beta, TNF-alpha, NLRP3, and iNOS were determined in the prefrontal cortex. Results: It was confirmed that quercetin increased the seizure threshold. And quercetin increased TAC, and decreased levels of MDA as well as gene expression of TNF- alpha, NLRP3, IL-1 beta, and iNOS in the prefrontal cortex at the time of seizure induction. Conclusion: It was suggested that the anticonvulsant effect of quercetin in PTZ-induced seizures in mice may be due to the reduction of inflammatory responses and oxidative stress in the prefrontal cortex.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据