The SNP rs4591246 in pri-miR-1-3p is associated with abdominal aortic aneurysm risk by regulating cell phenotypic transformation via the miR-1-3p/TLR4 axis

Review Cell Biology

Aortic Wall Inflammation in the Pathogenesis, Diagnosis and Treatment of Aortic Aneurysms

Georgia Skotsimara et al.

Summary: Inflammation plays a crucial role in the development of aortic aneurysms. Serum biomarkers and imaging techniques can be used for early diagnosis and treatment of this disease.

INFLAMMATION (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

AAA Revisited: A Comprehensive Review of Risk Factors, Management, and Hallmarks of Pathogenesis

Veronika Kessler et al.

Summary: Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular condition, with a prevalence of about 2-3% in the industrialized world. Older men with a history of smoking are at a higher risk for developing AAA. Screening programs can help detect and prevent ruptures of the aorta, which have a high associated death rate.

BIOMEDICINES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

LncRNA H19 Regulates Proliferation, Apoptosis and ECM Degradation of Aortic Smooth Muscle Cells Via miR-1-3p/ADAM10 Axis in Thoracic Aortic Aneurysm

Zhineng Fan et al.

Summary: In patients with Thoracic aortic aneurysm (TAA), the overexpression of long non-coding RNA H19 was found to inhibit VSMC proliferation, accelerate apoptosis and ECM degradation. Changes in miR-1-3p and ADAM10 were also observed in TAA, with H19 influencing ADAM10 expression by targeting miR-1-3p.

BIOCHEMICAL GENETICS (2022)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Systematic review of genome-wide association studies of abdominal aortic aneurysm

Tejas P. Singh et al.

Summary: This study systematically reviewed previous AAA GWAS and identified 33 SNPs associated with AAA diagnosis at genome-wide significance. However, the association between SNPs and AAA growth was not adequately examined. Previous GWAS have various design limitations, such as inconsistent case and control ascertainment and limited phenotyping of the AAAs.

ATHEROSCLEROSIS (2021)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Abdominal aortic aneurysms

John Anagnostakos et al.

Summary: Abdominal aortic aneurysms (AAA) are common in older adults and can lead to serious morbidity and mortality if not treated promptly. The causes include trauma, infection, and inflammatory disorders, with risk factors such as smoking, advanced age, dyslipidemia, hypertension, and coronary artery disease. The pathophysiology involves arterial insult leading to inflammation and weakening of the arterial wall, requiring monitoring of size and growth rate to prevent rupture. Management options include controlling risk factors, surgical intervention based on risk assessment, and post-operative monitoring for complications. Advancements in technology have improved the diagnosis and treatment of AAA in recent years.

PROGRESS IN CARDIOVASCULAR DISEASES (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

The elevated expression of TLR4 and MMP9 in human abdominal aortic aneurysm tissues and its implication

Tan Li et al.

Summary: This study revealed the increased expression of TLR4 and MMP9 in human AAA tissues, with lymphocytes showing a higher positive rate. TLR4 and MMP9 levels were related to circulating CRP, and high TLR4 expression was associated with larger AAA while high MMP9 expression was linked to thrombus presence within AAA.

BMC CARDIOVASCULAR DISORDERS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

rs41291957 controls miR-143 and miR-145 expression and impacts coronary artery disease risk

Ignacio Fernando Hall et al.

Summary: The study identifies a SNP, rs41291957 (A), near the miR-143/145 cluster that upregulates miR-143 and miR-145, modulating vascular smooth cell phenotype and acting as a protective factor against coronary artery disease.

EMBO MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A non-coding genetic variant associated with abdominal aortic aneurysm alters ERG gene regulation

Judith Marsman et al.

HUMAN MOLECULAR GENETICS (2020)

添加到收藏夹

Review Genetics & Heredity

Genetic and epigenetic regulation of abdominal aortic aneurysms

Kevin D. Mangum et al.

CLINICAL GENETICS (2020)

添加到收藏夹

Article Hematology

ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)-Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm

Sayantan Jana et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm

Rijan Gurung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation

Naijin Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

MicroRNAs and regulation of cardiometabolic phenotypes: novel insights into the complexity of genome-wide association studies loci

Mete Civelek et al.

CARDIOVASCULAR RESEARCH (2019)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Postpartum profiling of microRNAs involved in pathogenesis of cardiovascular/cerebrovascular diseases in women exposed to pregnancy-related complications

Ilona Hromadnikova et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Vascular smooth muscle-MAPK14 is required for neointimal hyperplasia by suppressing VSMC differentiation and inducing proliferation and inflammation

Wen Wu et al.

REDOX BIOLOGY (2019)

添加到收藏夹

Review Hematology

Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation Involvement of Vitamin K-Dependent Processes

Ploingarm Petsophonsakul et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

添加到收藏夹

Article Hematology

SM22α (Smooth Muscle 22α) Prevents Aortic Aneurysm Formation by Inhibiting Smooth Muscle Cell Phenotypic Switching Through Suppressing Reactive Oxygen Species/NF-κB (Nuclear Factor-κB)

Lintao Zhong et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

添加到收藏夹

Article Medicine, General & Internal

Tissue-Specific miRNAs Regulate the Development of Thoracic Aortic Aneurysm: The Emerging Role of KLF4 Network

Stase Gasiule et al.

JOURNAL OF CLINICAL MEDICINE (2019)

添加到收藏夹

Review Health Care Sciences & Services

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

Imadeldin Elfaki et al.

JOURNAL OF PERSONALIZED MEDICINE (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Correlation of the predisposition of Chinese children to cerebral palsy with nucleotide variation in pri-miR-124 that alters the non-canonical apoptosis pathway

Hui Li et al.

ACTA PHARMACOLOGICA SINICA (2018)

添加到收藏夹

Article Physiology

Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1

Justin R. Sysol et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Genetic polymorphisms offer insight into the causal role of microRNA in coronary artery disease

Andrea Borghini et al.

ATHEROSCLEROSIS (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Comparing miRNA structure of mirtrons and non-mirtrons

Igor I. Titov et al.

BMC GENOMICS (2018)

添加到收藏夹

Article Medical Laboratory Technology

Serum Toll-like receptor 4: A novel and promising biomarker for identification of aortic aneurysmal diseases

Tan Li et al.

CLINICA CHIMICA ACTA (2018)

添加到收藏夹

Review Genetics & Heredity

microRNA single polynucleotide polymorphism influences on microRNA biogenesis and mRNA target specificity

Jaroslaw Kroliczewski et al.

GENE (2018)

添加到收藏夹

Article Medicine, Research & Experimental

MiR-1-3p that correlates with left ventricular function of HCM can serve as a potential target and differentiate HCM from DCM

Mengmeng Li et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2018)

添加到收藏夹

Review Immunology

Modulation of Immune-Inflammatory Responses in Abdominal Aortic Aneurysm: Emerging Molecular Targets

Hanrong Li et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Novel determinants of mammalian primary microRNA processing revealed by systematic evaluation of hairpin-containing transcripts and human genetic variation

Christine Roden et al.

GENOME RESEARCH (2017)

添加到收藏夹

Editorial Material Hematology

Aortic Aneurysm In Defense of the Vascular Smooth Muscle Cell

Ha Won Kim et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Toll-Like Receptor 4 Is Essential in the Development of Abdominal Aortic Aneurysm

Chao-Han Lai et al.

PLOS ONE (2016)

添加到收藏夹

Article Peripheral Vascular Disease

TMEM16A and Myocardin Form a Positive Feedback Loop That Is Disrupted by KLF5 During Ang II-Induced Vascular Remodeling

Xin-hua Zhang et al.

HYPERTENSION (2015)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Angiotensin II-induced TLR4 mediated abdominal aortic aneurysm in apolipoprotein E knockout mice is dependent on STAT3

Zhexue Qin et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

添加到收藏夹

Article Oncology

A single nucleotide polymorphism in primary-microRNA-146a reduces the expression of mature microRNA-146a in patients with Alzheimer's disease and is associated with the pathogenesis of Alzheimer's disease

Bin Zhang et al.

MOLECULAR MEDICINE REPORTS (2015)

添加到收藏夹

Review Genetics & Heredity

Genetic variants in microRNA genes: impact on microRNA expression, function, and disease

Sophia Cammaerts et al.

FRONTIERS IN GENETICS (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA

Ranhui Duan et al.

HUMAN MOLECULAR GENETICS (2007)

添加到收藏夹

Article Multidisciplinary Sciences

The functions of animal microRNAs

V Ambros

NATURE (2004)

添加到收藏夹

Review Physiology

Molecular regulation of vascular smooth muscle cell differentiation in development and disease

GK Owens et al.

PHYSIOLOGICAL REVIEWS (2004)

添加到收藏夹

The SNP rs4591246 in pri-miR-1-3p is associated with abdominal aortic aneurysm risk by regulating cell phenotypic transformation via the miR-1-3p/TLR4 axis

相关参考文献

导出引文

分享论文