The role of miR-155 on liver diseases by modulating immunity, inflammation and tumorigenesis

The liver is a well-known metabolic organ that can be susceptible to external stimuli to affect its normal physiological function. Worldwide, the morbidity and mortality of liver diseases are skyrocketing every year, causing human health crises. Recently, new approaches such as biotechnology have been introduced to achieve optimal treatment and prognostic management of liver diseases. microRNAs (miRNAs), a kind of small noncoding RNA molecule, have the advantages of biodiversity, wide distribution and numerous members. Among these miRNAs, miR-155 is an important regulator of inflammation, immunity and tumorigenesis. In this review, the PubMed and Web of Science databases were searched from 2009 to 2022. After inclusion and exclusion, 64 articles were selected for a systematic review to comprehensively summarize the mechanisms of miR-155 regulating inflammation, immunity and tumorigenesis in liver diseases and liver cancer, covering in vitro, in vivo and clinical studies. Existing preclinical studies and clinical trials have listed that the up-regulation and down-regulation of miR-155 are significant in alcoholic liver injury, viral hepatitis, autoimmune hepatitis, infectious liver injury, liver transplantation and liver cancer. The immune and inflammation effects of miR-155 are manifested by regulating macrophage polarization, NK cell killing, Th17 cell and Th1/Th2 cell differentiation. Additionally, miR-155 is also committed to participating in the cell cycle, invasion and metastasis, immune escape and other processes to promote and intensify the development of liver cancer. In conclusion, miR-155 is not only a biomarker for the diagnosis and prognosis of liver diseases, but also plays a therapeutic role via regulating immunity, inflammation and tumorigenesis.

Automated summary

The liver is susceptible to external stimuli and its dysfunction leads to liver diseases with increasing morbidity and mortality worldwide. miR-155, a small noncoding RNA molecule, regulates inflammation, immunity, and tumorigenesis in liver diseases and liver cancer. Through a systematic review of 64 articles, miR-155 is shown to be significantly involved in alcoholic liver injury, viral hepatitis, autoimmune hepatitis, infectious liver injury, liver transplantation, and liver cancer. It regulates macrophage polarization, NK cell killing, and Th17 cell differentiation, and participates in the development of liver cancer through cell cycle regulation, invasion, metastasis, and immune escape. miR-155 serves as a biomarker for diagnosis and prognosis, and also has therapeutic potential in liver diseases by modulating immunity, inflammation, and tumorigenesis.