☆ 4.7 Review

Indoleamine 2,3-dioxygenase 1 in circumventing checkpoint inhibitor responses: Updated

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Medicine, Research & Experimental

Bypassing anti-PD-(L)1 therapy: Mechanisms and management strategies

Keywan Mortezaee et al.

Summary: Resistance to immune checkpoint inhibitors is a major challenge in cancer immunotherapy, as immune evasion is a complex event that occurs in cold immune environments. More research is needed to understand the mechanisms of immune escape in different types of tumors and develop strategies to enhance tumor sensitivity to anti-PD-(L)1 therapy.

BIOMEDICINE & PHARMACOTHERAPY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma

Tyler Risom et al.

Summary: This study used MIBI-TOF and antibody staining methods to analyze the changes in the tumor microenvironment (TME) between DCIS and IBC. Four coordinated transitions between TME states were identified. The study also found that myoepithelial disruption was more advanced in DCIS patients who did not develop IBC, suggesting a potential protective effect against recurrence.

CELL (2022)

添加到收藏夹

Article Immunology

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

Kebria Hezaveh et al.

Summary: The study demonstrates the critical role of AhR in the function of tumor-associated macrophages (TAMs) in PDAC, showing that deletion of Ahr reduces PDAC growth, increases the frequency of IFN CD8(+) T cells, and dietary tryptophan metabolism affects AhR activity through the conversion of tryptophan to indoles by Lactobacillus. High AHR expression in PDAC patients is associated with disease progression, mortality, and an immune-suppressive TAM phenotype, indicating a conserved regulatory axis in human disease.

IMMUNITY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Development and validation of a prognostic and predictive 32-gene signature for gastric cancer

Jae-Ho Cheong et al.

Summary: The ability to predict the survival and response to treatment of gastric cancer patients can be improved by generating a 32 gene signature. This study identifies four prognostic molecular subtypes through genomic profiling and shows that the 32-gene signature is a promising prognostic and predictive biomarker for guiding the clinical care of gastric cancer patients.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer

Alok Kumar Singh et al.

Summary: This study re-engineered the BCG vaccine to express high levels of the PAMP molecule c-di-AMP, leading to augmented immune responses, enhanced induction of trained immunity, and improved antitumor efficacy in pre-clinical models of bladder cancer.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Cell Biology

Metabolic adaptation of ovarian tumors in patients treated with an IDO1 inhibitor constrains antitumor immune responses

Kunle Odunsi et al.

Summary: The study reveals that inhibition of IDO1 in ovarian cancer may result in metabolic adaptation and undermine antitumor T cell responses in the tumor microenvironment.

SCIENCE TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2,3-dioxygenase-blockade tumor immunotherapy

Liangliang Dai et al.

Summary: This study reports on the co-delivery of glucose oxidase and IDO inhibitor using a metal-organic framework-based nanoreactor, showing an amplified release for tumor starvation/oxidation immunotherapy. The nanosystem overcomes biobarriers associated with tumor penetration, rapidly disassembles and releases cargoes in response to intracellular reactive oxygen species. The combined IDO-blockade immunotherapy enhances immune response and inhibits tumor growth significantly.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Cell Biology

A pan-cancer metabolic atlas of the tumor microenvironment

Neha Rohatgi et al.

Summary: Through a tumor transcriptome deconvolution approach, we identified fundamental differences in metabolic states of cancer and stromal cells inside tumors, including the upregulation of deoxythymidine triphosphate (dTTP) and overexpression of tryptophan catabolism rate-limiting enzymes in stroma. Furthermore, we found that oxidative phosphorylation is more upregulated in cancer cells in vivo compared to stromal cells and a large atlas of cancer cell lines, suggesting a less pronounced Warburg effect in cancer cells.

CELL REPORTS (2022)

添加到收藏夹

Review Oncology

Checkpoint inhibitor/interleukin-based combination therapy of cancer

Keywan Mortezaee et al.

Summary: This review discusses the potential of using ILs and IL-targeting drugs in combination with ICI in cancer immunotherapy, and describes recent advances in the field using PEGylated ILs and fusion proteins. The key focus in this area is to reduce adverse events and increase the efficacy and durability of combination therapy.

CANCER MEDICINE (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Immunogenomic landscape analyses of immune molecule signature-based risk panel for patients with triple-negative breast cancer

Cun Liu et al.

Summary: Molecular-based phenotypic characterization of TNBC tumors and their immunity can provide useful prognostic signatures and play an important role in clinical decision-making for TNBC patients.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

添加到收藏夹

Review Medicine, Research & Experimental

VISTA immune regulatory effects in bypassing cancer immunotherapy: Updated

Keywan Mortezaee et al.

Summary: VISTA, as a member of the CD28/B7 family, is highly expressed in the TME, shaping an immunosuppressive environment by blunting the activity of immune cells and strengthening tumor cells. Combination of anti-VISTA with ICIs can enhance T cell effector activity and tumor immunogenicity, leading to more pronounced responses.

LIFE SCIENCES (2022)

添加到收藏夹

Article Oncology

Anti-TGF-beta/PD-L1 bispecific antibody promotes T cell infiltration and exhibits enhanced antitumor activity in triple-negative breast cancer

Ming Yi et al.

Summary: In this study, a bispecific antibody targeting TGF-beta and human PD-L1 was developed and showed strong antitumor effects in triple-negative breast cancer (TNBC). The bispecific antibody exhibited high binding affinity to its targets and effectively counteracted immunosuppressive signaling pathways. In vivo experiments demonstrated that the bispecific antibody had superior antitumor activity compared to monotherapies targeting the individual targets. The improved tumor microenvironment contributed to its potent antitumor effects. This study suggests that the bispecific antibody may be a promising agent for TNBC treatment.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

添加到收藏夹

Review Medicine, Research & Experimental

Cancer stem cells in immunoregulation and bypassing anti-checkpoint therapy

Elnaz Rouzbahani et al.

Summary: The tumor microenvironment plays a critical role in tumor resistance to immune checkpoint inhibitors. Cancer stem cells suppress the infiltration of CD8+ T cells and promote the recruitment of certain immune cells, such as macrophages and neutrophils. This study indicates that targeting cancer stem cells is a key step in effectively breaking down the tumor and reducing tumor recurrence after immunotherapy.

BIOMEDICINE & PHARMACOTHERAPY (2022)

添加到收藏夹

Review Oncology

Extracellular vesicle-based checkpoint regulation and immune state in cancer

Keywan Mortezaee et al.

Summary: Tumor cells exploit various mechanisms, such as equipping extracellular vesicles with checkpoints, to evade immune surveillance and promote metastasis. Evaluating circulatory exosomal PD-L1 can serve as a prognostic biomarker for tumor diagnosis and responses to immune checkpoint inhibitor therapy. Harvesting and modifying EVs from tumors may be a promising strategy in cancer immunotherapy.

MEDICAL ONCOLOGY (2022)

添加到收藏夹

Article Oncology

Comprehensive assessment of multiple tryptophan metabolites as potential biomarkers for immune checkpoint inhibitors in patients with non-small cell lung cancer

M. Karayama et al.

Summary: The study found significant differences in tryptophan metabolite levels between patients with non-small cell lung cancer and healthy volunteers, with 3-HAA levels correlating with treatment outcomes. Analysis of 3-HAA values can predict the efficacy of ICIs treatment.

CLINICAL & TRANSLATIONAL ONCOLOGY (2021)

添加到收藏夹

Review Cell Biology

Redox tolerance and metabolic reprogramming in solid tumors

Keywan Mortezaee

Summary: Tumor cells need to acquire characteristics more potent than normal cells in order to survive and grow in the host environment. This includes having stronger redox tolerance and adaptive metabolic processes. Without these characteristics, tumors are prone to disruption.

CELL BIOLOGY INTERNATIONAL (2021)

添加到收藏夹

Article Immunology

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor

Yuying Liu et al.

Summary: IL-2 acts as an environmental cue to induce CD8(+) T cell exhaustion within tumor microenvironments by activating STAT5, inducing tryptophan hydroxylase 1, and subsequently causing T cell dysfunction.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity

Madhav D. Sharma et al.

Summary: Pharmacologic inhibition of BTK and IDO pathways or deletion of Btk or Ido1 promotes differentiation of inflammatory DCs during chemotherapy, inhibiting tumor growth and enhancing antitumor T cell responses. Immature precursor cells can differentiate into mature DCs through epigenetic profiles similar to conventional DCs.

IMMUNITY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Inhibition of indoleamine 2,3-dioxygenase 1 synergizes with oxaliplatin for efficient colorectal cancer therapy

Xiaofei Miao et al.

Summary: Oxaliplatin induces immunogenic cell death in murine colorectal cancer, greatly relying on the host immune response. Oxaliplatin also promotes BMDC maturation and CD8(+) T cell expansion, while inhibition of IDO1 significantly enhances the therapeutic effects of oxaliplatin against colorectal cancer.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

添加到收藏夹

Article Microbiology

Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice

Se-Hoon Lee et al.

Summary: Specific strains of Bifidobacterium bifidum can reduce tumor burden synergistically with PD-1 blockade or oxaliplatin treatment by eliciting an antitumor host immune response, indicating their potential therapeutic use.

NATURE MICROBIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A phase 1/2 trial of an immune-modulatory vaccine against IDO/PD-L1 in combination with nivolumab in metastatic melanoma

Julie Westerlin Kjeldsen et al.

Summary: The IO102/IO103 vaccine targeting IDO/PD-L1, combined with nivolumab, showed favorable safety and clinical efficacy in treating metastatic melanoma, with an 80% objective response rate and 43% complete responses. This immunomodulatory approach warrants further validation in larger randomized trials to confirm its clinical potential.

NATURE MEDICINE (2021)

添加到收藏夹

Article Oncology

The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1

Ming Yi et al.

Summary: The bispecific antibody YM101 can simultaneously target the TGF-beta and PD-L1 pathways, demonstrating superior anti-tumor efficacy. YM101 enhances the anti-tumor immune response by increasing the numbers of tumor infiltrating lymphocytes and dendritic cells, elevating the ratio of M1/M2, and enhancing cytokine production in T cells.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response

Yu-Ting Yen et al.

Summary: This study demonstrates that inactivation of protein phosphatase 2A (PP2A) converts cold microsatellite-stable (MSS) tumors into microsatellite-instable (MSI) tumors, promoting cytotoxic T cell infiltration and response to immune checkpoint blockade (ICB).

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells

Alice Clare Newman et al.

Summary: Cancer cells adapt their metabolism to meet the increased demands for synthesis. Recent research has focused on nutrients that supply one-carbon units to the folate cycle, particularly serine. Tryptophan can serve as a theoretical source of one-carbon units through metabolism by IDO1, and cancer cells release tryptophan-derived formate that can be utilized by other cells.

MOLECULAR CELL (2021)

添加到收藏夹

Article Cell Biology

Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy

Nicholas C. DeVito et al.

Summary: Inhibition of Wnt signaling pathway can enhance the sensitivity of cancer patients to immune checkpoint blockade by reversing immune suppression cells in the tumor microenvironment. These findings provide a rationale for Wnt ligand-focused treatment approaches in future immunotherapy clinical trials and suggest a strategy for selecting tumors more responsive to Wnt inhibition.

CELL REPORTS (2021)

添加到收藏夹

Review Cell Biology

Normalization in tumor ecosystem: Opportunities and challenges

Keywan Mortezaee

Summary: Current research in cancer therapy focuses on reversing abnormalities within the tumor stroma by strategies such as vascular normalization, metabolic modulation, balancing cellular dispersion, and pH and O-2 delivery balance to restore the ecosystem balance for long-lasting effects on tumors.

CELL BIOLOGY INTERNATIONAL (2021)

添加到收藏夹

Article Immunology

Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

Kevin Mulder et al.

Summary: This study integrated a large number of mononuclear phagocytes from 13 tissues to generate a MNP single-cell RNA compendium, revealing conserved gene signatures and specialized cell subsets across multiple tissues. Specific macrophage populations were found to be expanded in cancer and inflammation, with tumor-associated macrophage populations present in all neoplastic tissues.

IMMUNITY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The current knowledge concerning solid cancer and therapy

Masoud Najafi et al.

Summary: Solid cancers pose a significant global health burden, with various treatment strategies available. Surgical resection, radiotherapy, and chemotherapy are common approaches, but there are challenges in achieving optimal outcomes, leading to ongoing research and the exploration of alternative therapies like immunotherapy and EV therapy.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

添加到收藏夹

Letter Oncology

The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia

Xing-chen Ding et al.

Summary: The study showed a positive correlation between PD-L1 and HIF-1α in glioma, with their overexpression associated with poor survival. HIF-1α was found to induce PD-L1 expression under hypoxic conditions, which could be abrogated by inhibiting HIF-1α. Combination therapy of HIF-1α inhibitor and anti-PD-L1 antibody demonstrated enhanced tumor growth suppression and improved immune activation.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Myeloid-derived suppressor cells in cancer immunotherapy-clinical perspectives

Keywan Mortezaee

Summary: Myeloid-derived suppressor cells (MDSCs) are a group of immature immune cells that significantly increase in cancer patients, releasing factors that impact tumor-related events such as metastasis and immune evasion, and can serve as an indicator of tumor prognosis. They can be targeted in combination with current immunotherapies to enhance the immune system's response against tumors.

LIFE SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics

Veerle W. Daniels et al.

Summary: Cancer cells, particularly triple-negative breast cancer cells, were found to exhibit increased mitochondrial apoptotic priming and sensitivity to BH3 mimetics when treated with NAMPT inhibitors. These findings suggest a close interaction between metabolic vulnerabilities and mitochondrial apoptotic signaling pathways in some TNBC cells, providing new insights into potential targeted therapy for this subtype of breast cancer.

SCIENCE SIGNALING (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?

Niklas Joisten et al.

Summary: The dysregulation of the kynurenine pathway in tryptophan metabolism is associated with inflammation-driven pathologies, making it a potential therapeutic target for diseases such as cancer and brain disorders. It is important to consider both compensatory mechanisms and bioenergetic roles of KP metabolites in designing effective therapeutic approaches to attenuate disease progression.

TRENDS IN MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Profiling the inhibitory receptors LAG-3, TIM-3, and TIGIT in renal cell carcinoma reveals malignancy

Kimiharu Takamatsu et al.

Summary: Targeting inhibitory receptors (IRs) LAG-3, TIM-3, and TIGIT in immunotherapy for human renal cell carcinoma is promising, with individual IR levels serving as potential biomarkers for analysis. The immunogenomic landscape of the disease can be investigated through automated single-cell counting for these IRs.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression

I-Na Lu et al.

Summary: HSPCs in glioblastoma tumor tissues are associated with malignant and immunosuppressive phenotypes, predicting patient survival and potentially serving as a target for brain tumor immunotherapies. A deeper understanding of the immune cell profile within the brain cancer tumor microenvironment could lead to improved immunotherapy efficacy.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Oncology

Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas

Mirco Friedrich et al.

Summary: The study identifies different states of myeloid cells in gliomas and demonstrates that IDH-mutant tumors re-educate infiltrating macrophages through tryptophan metabolism, resulting in the formation of an immunosuppressive microenvironment. This suggests that targeting tryptophan metabolism could be a potential immunotherapy strategy for IDH-mutant tumors.

NATURE CANCER (2021)

添加到收藏夹

Article Oncology

Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells

Yun Wang et al.

Summary: The study demonstrates that the EP4 inhibitor MF-766 synergizes with anti-PD-1 therapy to enhance anti-tumor activity by modulating infiltration profiles of myeloid cells, NK cells, cDCs, and T-cells in the tumor microenvironment (TME).

ONCOIMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencing

Xudong Xing et al.

Summary: This study provides single-cell transcriptomic profiling of SSN and their TME, revealing that cytotoxic natural killer/I cells dominate the TME of SSN, and malignant cells in SSN undergo metabolic reprogramming and immune stress. Furthermore, the subtype composition of endothelial cells in SSN is similar to that in mLUAD, while the subtype distribution of fibroblasts is more like that in nLung.

SCIENCE ADVANCES (2021)

添加到收藏夹

Article Oncology

High Stromal TGFBI in Lung Cancer and Intratumoral CD8-Positive T Cells were Associated with Poor Prognosis and Therapeutic Resistance to Immune Checkpoint Inhibitors

Nobuhiro Nakazawa et al.

ANNALS OF SURGICAL ONCOLOGY (2020)

添加到收藏夹

Review Oncology

Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization

Keywan Mortezaee et al.

CURRENT CANCER DRUG TARGETS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase

Xuexiang Han et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

添加到收藏夹

Article Oncology

Peptide vaccination directed against IDO1-expressing immune cells elicits CD8+and CD4+T-cell-mediated antitumor immunity and enhanced anti-PD1 responses

Souvik Dey et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

Luis Felipe Campesato et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Medicine, Research & Experimental

The role of curcumin/curcuminoids during gastric cancer chemotherapy: A systematic review of non-clinical study

Masoud Najafi et al.

LIFE SCIENCES (2020)

添加到收藏夹

Article Cell Biology

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

Yang Gao et al.

NATURE CELL BIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells

Valenti Gomez et al.

SCIENCE SIGNALING (2020)

添加到收藏夹

Article Cell Biology

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation

Bruno Lamas et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Anti-tumour immunity induces aberrant peptide presentation in melanoma

Osnat Bartok et al.

NATURE (2020)

添加到收藏夹

Article Oncology

Phase I Study of the Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Navoximod (GDC-0919) Administered with PD-L1 Inhibitor (Atezolizumab) in Advanced Solid Tumors

Kyung Hae Jung et al.

CLINICAL CANCER RESEARCH (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

The landscape of cancer cell line metabolism

Haoxin Li et al.

NATURE MEDICINE (2019)

添加到收藏夹

Article Oncology

Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study

Georgina Long et al.

LANCET ONCOLOGY (2019)

添加到收藏夹

Meeting Abstract Oncology

Identification of BAY-218, a potent and selective small-molecule AhR inhibitor, as a new modality to counteract tumor immunosuppression

Norbert Schmees et al.

CANCER RESEARCH (2019)

添加到收藏夹

Article Multidisciplinary Sciences

In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis

Uma S. Gautam et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Bertrand Routy et al.

SCIENCE (2018)

添加到收藏夹

Article Oncology

Tumor-Repopulating Cells Induce PD-1 Expression in CD8(+) T Cells by Transferring Kynurenine and AhR Activation

Yuying Liu et al.

CANCER CELL (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme

Todd A. Triplett et al.

NATURE BIOTECHNOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

Ludivine Laurans et al.

NATURE MEDICINE (2018)

添加到收藏夹

Article Multidisciplinary Sciences

The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients

Vyara Matson et al.

SCIENCE (2018)

添加到收藏夹

Article Oncology

A Longitudinal Analysis of IDO and PDL1 Expression during Immune- or Targeted Therapy in Advanced Melanoma

Lukas Krahenbuhl et al.

NEOPLASIA (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

Franz L. Ricklefs et al.

SCIENCE ADVANCES (2018)

添加到收藏夹

Article Oncology

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

Asha Nayak-Kapoor et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

添加到收藏夹

Article Oncology

Epacadostat Plus Pembrolizumab in Patients With Advanced Solid Tumors: Phase I Results From a Multicenter, Open-Label Phase I/II Trial (ECHO-202/KEYNOTE-037)

Tara C. Mitchell et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

添加到收藏夹

Meeting Abstract Oncology

Epacadostat plus nivolumab for advanced melanoma: Updated phase 2 results of the ECHO-204 study

Adil Daud et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

添加到收藏夹

Article Oncology

Epacadostat plus pembrolizumab in patients with advanced melanoma and select solid tumors: Updated phase 1 results from ECHO-202/KEYNOTE-037

T.C. Gangadhar et al.

ANNALS OF ONCOLOGY (2017)

添加到收藏夹

Article Immunology

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells

Giada Mondanelli et al.

IMMUNITY (2017)

添加到收藏夹

Article Pathology

Negative immune checkpoint regulation by VISTA: a mechanism of acquired resistance to anti-PD-1 therapy in metastatic melanoma patients

Hojabr Kakavand et al.

MODERN PATHOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer

Jianjun Gao et al.

NATURE MEDICINE (2017)

添加到收藏夹

Article Chemistry, Medicinal

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (ID01) Inhibitor for Immunooncology

Eddy W. Yue et al.

ACS MEDICINAL CHEMISTRY LETTERS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1

Ariel Lewis-Ballester et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression

Jianqin Lu et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Oncology

Prostaglandin E2 and PD-1 mediated inhibition of antitumor CTL responses in the human tumor microenvironment

Jie Miao et al.

ONCOTARGET (2017)

添加到收藏夹

Meeting Abstract Oncology

Combination immunotherapy with IDO vaccine and PD-1 inhibitors in advanced NSCLC.

Anders Mellemgaard et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

添加到收藏夹

Meeting Abstract Oncology

A phase Ib dose escalation study of combined inhibition of IDO1 (GDC-0919) and PD-L1 (atezolizumab) in patients (pts) with locally advanced or metastatic solid tumors

Howard A. Burris et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

添加到收藏夹

Meeting Abstract Oncology

Interim analysis of the Phase 2 clinical trial of the IDO pathway inhibitor indoximod in combination with pembrolizumab for patients with advanced melanoma

Yousef Zakharia et al.

CANCER RESEARCH (2017)

添加到收藏夹

Meeting Abstract Oncology

BMS-986205, an optimized indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, is well tolerated with potent pharmacodynamic (PD) activity, alone and in combination with nivolumab (nivo) in advanced cancers in a phase 1/2a trial

Lillian L. Siu et al.

CANCER RESEARCH (2017)

添加到收藏夹

Article Oncology

First-in-Human Phase I Study of the Oral Inhibitor of Indoleamine 2,3-Dioxygenase-1 Epacadostat (INCB024360) in Patients with Advanced Solid Malignancies

Gregory L. Beatty et al.

CLINICAL CANCER RESEARCH (2017)

添加到收藏夹

Meeting Abstract Oncology

Epacadostat plus pembrolizumab in patients with advanced RCC: Preliminary phase I/II results from ECHO-202/KEYNOTE-037.

Primo Lara et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

The aryl hydrocarbon receptor links integrin signaling to the TGF-β pathway

M. Silginer et al.

ONCOGENE (2016)

添加到收藏夹

Meeting Abstract Oncology

Updated results from a phase 1/2 study of epacadostat (INCB024360) in combination with ipilimumab in patients with metastatic melanoma

G. Gibney et al.

EUROPEAN JOURNAL OF CANCER (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Marie Vetizou et al.

SCIENCE (2015)

添加到收藏夹

Article Immunology

PGE2-Induced IDO1 Inhibits the Capacity of Fully Mature DCs to Elicit an In Vitro Antileukemic Immune Response

Sara Trabanelli et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2015)

添加到收藏夹

Article Multidisciplinary Sciences

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

Madhav D. Sharma et al.

SCIENCE ADVANCES (2015)

添加到收藏夹

Article Oncology

PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials

Jason Madore et al.

PIGMENT CELL & MELANOMA RESEARCH (2015)

添加到收藏夹

Article Dermatology

Peritumoral indoleamine 2,3-dioxygenase expression in melanoma: an early marker of resistance to immune control?

I. Chevolet et al.

BRITISH JOURNAL OF DERMATOLOGY (2014)

添加到收藏夹

Meeting Abstract Oncology

Synergistic antitumor effects of combinatorial immune checkpoint inhibition with anti-PD-1/PD-L antibodies and the IDO pathway inhibitors NLG-919 and indoximod in the context of active immunotherapy

Mario R. Mautino et al.

CANCER RESEARCH (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Diet rapidly and reproducibly alters the human gut microbiome

Lawrence A. David et al.

NATURE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

Alban Bessede et al.

NATURE (2014)

添加到收藏夹

Article Oncology

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment

Stefani Spranger et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase

Kyung Tae Noh et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)

添加到收藏夹

Article Immunology

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

Rikke B. Holmgaard et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

添加到收藏夹

Article Cell Biology

Up-Regulation of PD-L1, IDO, and Tregs in the Melanoma Tumor Microenvironment Is Driven by CD8+ T Cells

Stefani Spranger et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

添加到收藏夹

Article Oncology

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

Seng-Ryong Woo et al.

CANCER RESEARCH (2012)

添加到收藏夹

Article Oncology

Indoleamine 2,3-dioxygenase, a new prognostic marker in sentinel lymph nodes of melanoma patients

Reinhart Speeckaert et al.

EUROPEAN JOURNAL OF CANCER (2012)

添加到收藏夹

Article Immunology

Activated CD69+ T Cells Foster Immune Privilege by Regulating IDO Expression in Tumor-Associated Macrophages

Qiyi Zhao et al.

JOURNAL OF IMMUNOLOGY (2012)

添加到收藏夹

Article Immunology

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

Maria T. Pallotta et al.

NATURE IMMUNOLOGY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Curcumin Suppresses the Induction of Indoleamine 2,3-Dioxygenase by Blocking the Janus-activated Kinase-Protein Kinase Cδ-STAT1 Signaling Pathway in Interferon-γ-stimulated Murine Dendritic Cells

Young-Il Jeong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Aryl hydrocarbon receptor inhibition downregulates the TGF-β/Smad pathway in human glioblastoma cells

D. Gramatzki et al.

ONCOGENE (2009)

添加到收藏夹

Article Hematology

CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition

Michael S. von Bergwelt-Baildon et al.

BLOOD (2006)

添加到收藏夹

Article Multidisciplinary Sciences

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

E Sato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

添加到收藏夹

Article Immunology

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase

DH Munn et al.

IMMUNITY (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

AJ Muller et al.

NATURE MEDICINE (2005)

添加到收藏夹

Article Immunology

Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells

DH Munn et al.

JOURNAL OF IMMUNOLOGY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

C Uyttenhove et al.

NATURE MEDICINE (2003)

添加到收藏夹

Article Immunology

CTLA-4-Ig regulates tryptophan catabolism in vivo

U Grohmann et al.

NATURE IMMUNOLOGY (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

T cell apoptosis by tryptophan catabolism

I Fallarino et al.

CELL DEATH AND DIFFERENTIATION (2002)

添加到收藏夹

Article Immunology

Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells:: Mediation of suppression by tryptophan metabolites

P Terness et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.