期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 54, 期 -, 页码 82-92出版社
ELSEVIER
DOI: 10.1016/j.jmbbm.2015.09.016
关键词
Polylactide; Ceramic fillers; Biodegradable bone replacement
资金
- Federal Ministry of Education and Research [13N12131]
Recently a tri-phase material consisting of poly-(D,L-lactide) (PDLLA), beta-tricaldum phosphate (beta-TCP), and calcium carbonate (CC) was proposed as a novel bone substitute candidate. beta-TCP is suitable because of its bone-like mineral phase, PDLLA is introduced as a biodegradable adhesive phase, and CC is essential for buffering the acidic degradation of the lactate component. We hypothesize that the amounts of the three different components in the composite material must be carefully balanced in order to avoid issues such as accelerated degradation or pronounced volumetric swelling. To prove this, granulates made of different mixing ratios of the tri-phase compound were prepared by grinding. Specimens of the different compounds were manufactured by a hot pressing process. The bending strength of the specimens was determined before and after storing in demineralized water and phosphate buffered saline (PBS). The particle size of the compound granulates was smaller than 100 mu m. A ratio of 60 wt% of the PDLLA component indicated the best compromise between stability of test specimens based on a strong melting network and bone-like properties. The specimens exhibited a bending strength up to 90 MPa. The strength increased with an increasing ratio of beta-TCP to calcium carbonate (based on 60 wt% PDLLA). A vast volumetric swelling up to 40%, and thus a huge reduction of the bending strength, was observed during the storage of specimens in PBS. A swelling and thus a volume increase could be critical, especially for using the tri-phase bone substitute compound as 3D scaffold with defined dimensions. This must be considered with regard to the composition of the compound and the scaffold design. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据