Glycemic Excursion and Insulin Action Revealed in a Rare Case of Type 1 Diabetes Complicated with Short Bowel Syndrome

We herein report a 52-year-old woman with a rare combination of short bowel syndrome due to massive resection of the small intestine and complete loss of endogenous insulin due to type 1 diabetes. To provide nutritional support, she was treated with total parenteral nutrition with co-administration of insulin, requiring careful matching of insulin and glucose levels. This case report provides insights on glycemic excursion and insulin action in type 1 diabetes, even when both insulin and glucose are administered directly into circulation, and the usual obstacles caused by subcutaneous injection of insulin and oral intake of nutrients are eliminated.

Automated summary

In this case report, we present a 52-year-old woman with a rare combination of short bowel syndrome and complete loss of endogenous insulin due to type 1 diabetes. The patient was treated with total parenteral nutrition and co-administration of insulin, which provided insights on glycemic excursion and insulin action in type 1 diabetes without the usual obstacles of subcutaneous injection of insulin and oral intake of nutrients.