期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 54, 期 -, 页码 93-105出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2015.09.017
关键词
CABG; Bypass graft; Stress homeostasis; Mechanical compatibility
资金
- NIH INBRE Grant for South Carolina [P20GM103499]
- BMEN
- Office of Integrative Activities
- Office Of The Director [1317771] Funding Source: National Science Foundation
- Office Of The Director
- Office of Integrative Activities [GRANTS:13630810] Funding Source: National Science Foundation
Coronary artery bypass grafting (CABG) acutely disturbs the homeostatic state of the transplanted vessel making retention of graft patency dependent on chronic remodeling processes. The time course and extent to which remodeling restores vessel homeostasis will depend, in part, on the nature and magnitude of the mechanical disturbances induced upon transplantation. In this investigation, biaxial mechanical testing and histology were performed on the porcine left anterior descending artery (LAD) and analogs of common autografts, including the internal thoracic artery (ITA), radial artery (RA), great saphenous vein (GSV) and lateral saphenous vein (LSV). Experimental data were used to quantify the parameters of a structure-based constitutive model enabling prediction of the acute vessel mechanical response pre-transplantation and under coronary loading conditions. A novel metric Xi was developed to quantify mechanical differences between each graft vessel in situ and the LAD in situ, while a second metric Omega compares the graft vessels in situ to their state under coronary loading. The relative values of these metrics among candidate autograft sources are consistent with vessel specific variations in CABG clinical success rates with the ITA as the superior and GSV the inferior graft choices based on mechanical performance. This approach can be used to evaluate other candidate tissues for grafting or to aid in the development of synthetic and tissue engineered alternatives. (C) 2015 Elsevier Ltd. All rights reserved.
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