4.7 Review

Schiff bases and their metal Complexes: A review on the history, synthesis, and applications

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Synthesis of Pd +2 complexes of Schiff bases containing methyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate and spectral and catalytic activities

Kenan Buldurun et al.

Summary: In this study, ONS-donor atom containing Schiff base ligands (1, 2) were utilized to synthesize complexes 1a and 2a. The ligands were prepared using 2-hydroxy-3-methoxybenzaldehyde and 4-benzoxybenzaldehyde with a precursor in an ethanol medium. Pd(II) complexes (1a, 2a) were then formed by reacting the corresponding [PdCl2(CH3CN)2] with the Schiff base ligands in a 1:1 molar proportion. The molecular structures of the Schiff bases (1, 2) and their Pd(II) complexes (1a, 2a) were characterized using various analytical/spectroscopic techniques. The results demonstrated that the presence of complexes 1a and 2a as catalysts could facilitate Suzuki-Miyaura and Mizoroki-Heck cross-coupling reactions, leading to high-yield coupling products.

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Binuclear Zn(II) Schiff base complexes: Synthesis, spectral characterization, theoretical studies and antimicrobial investigations

Hadi Kargar et al.

Summary: Binuclear zinc(II) Schiff base complexes were synthesized and characterized through spectroscopic analysis, revealing their centrosymmetric nature and enhanced antimicrobial activity compared to the ligands. Additionally, theoretical calculations using density functional theory supported the experimental findings.

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Green synthesis approach for new Schiff's-base complexes; theoretical and spectral based characterization with in-vitro and in-silico screening

Arwa Alharbi et al.

Summary: Ball milling was utilized to synthesize new Schiff-base complexes from Co(II), Fe(III), Ni(II), and Zn(II) ions in solid form, with various spectroscopic and analytical methods used to determine their geometries. The complexes exhibited activity against microorganisms and liver cancer cells, supporting further development of potential medications. Computational treatments involving in-vitro and in-silico analyses demonstrated high consistency and provided insights for future drug development.

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Pd(II) and Ni(II) complexes containing ONNO tetradentate Schiff base ligand: Synthesis, crystal structure, spectral characterization, theoretical studies, and use of PdL as an efficient homogeneous catalyst for Suzuki-Miyaura cross-coupling reaction

Hadi Kargar et al.

Summary: Two new palladium(II) and nickel(II) Schiff base complexes were synthesized and characterized through CHN analysis, FT-IR, and H-1 NMR techniques. The crystal structure of the palladium(II) complex was determined using single crystal X-ray diffraction analysis. The theoretical calculations based on density functional theory agreed well with the experimental data.

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Synthesis, spectral characterization, crystal structures, biological activities, theoretical calculations and substitution effect of salicylidene ligand on the nature of mono and dinuclear Zn(II) Schiff base complexes

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Summary: Two new zinc(II) Schiff base complexes were synthesized and characterized, showing the influence of the Schiff base ligands on the structures of the complexes. The metal complexes exhibited higher antibacterial potential compared to free ligands, as demonstrated by inhibition zone assessments.

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Microwave-Assisted Synthesis of Schiff Base Metal-Ligand Complexes with Copper and Nickel Centres for Electrochemical In Vitro Sensing of Nitric Oxide in an Aqueous Solution

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Summary: The article discusses the important role of nitric oxide (NO) and the use of Schiff base complex electrochemical sensors for NO detection. Metal-ligand complexes of Cu and Ni were synthesized using coordination chemistry methods, demonstrating their efficacy in NO detection.

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Microwave-Assisted Synthesis: Can Transition Metal Complexes Take Advantage of This Green Method?

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Summary: This article reviews the various aspects and applications of Schiff-base ligands and their metal complexes. Significant advancements have been made in recent years, indicating promising future prospects.

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Synthesis, characterization, crystal structure, DNA and human serum albumin interactions, as well as antiproliferative activity of a Cu(II) complex containing a Schiff base ligand formed in situ from the Cu(II)-induced cyclization of 1,5-bis(salicylidene)thiocarbohydrazide

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Summary: A new dinuclear copper complex formed in solution and a tetranuclear compound in solid, exhibiting efficient DNA binding and anticancer activities. The complex showed strong binding affinity to human serum albumin and induced apoptosis in cancer cells.

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Summary: Schiff bases and their metal complexes are versatile compounds synthesized by condensation, with broad applications in biology, medicine, catalysis, and industry. They also serve as precursors for the synthesis of various metal oxides, which play important roles in catalysis and biological activity.

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Post-Synthesis modification of metal-organic frameworks using Schiff base complexes for various catalytic applications

Manpreet Kaur et al.

Summary: Metal-organic frameworks (MOFs) are porous crystalline materials built through the interconnection between metal clusters and organic linkers, with controllable structures and distribution of catalytically active sites via post-synthesis modification (PSM) using Schiff base. Schiff base complex-anchored MOFs play a significant role in various catalytic reactions, offering a promising strategy to develop highly effective and stable catalysts. These catalysts help overcome the limitations of homogeneous and heterogeneous catalysis, making them valuable for diverse catalytic applications.

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Recent progresses in Schiff bases as aqueous phase corrosion inhibitors: Design and applications

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A new Schiff base containing 5-FU and its metal Complexes: Synthesis, Characterization, and biological activities

Ahmet Savci et al.

Summary: The present study focused on synthesizing Schiff-based metal complexes derived from 5-Fluorouracil and characterizing their structures and properties through various spectroscopic methods. The metal complexes exhibited higher antioxidant activity compared to the ligand, with the Ru (II) metal complex showing the highest activity. However, 5-Fluorouracil demonstrated better antimicrobial activity than the synthesized compounds.

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Hadi Kargar et al.

Summary: A new dioxomolybdenum(VI) complex with tridentate ONO-donor Schiff base ligand derived from isoniazid was synthesized and characterized, showing efficient catalytic performance in oxidizing different sulfides in ethanol. Theoretical calculations confirmed the experimental results, and the complex achieved high yield and full selectivity in a short reaction time.

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Nickel(II), copper(II) and zinc(II) complexes containing symmetrical Tetradentate Schiff base ligand derived from 3,5-diiodosalicylaldehyde: Synthesis, characterization, crystal structure and antimicrobial activity

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Some new Cu(II) complexes containing O,N-donor Schiff base ligands derived from 4-aminoantipyrine: synthesis, characterization, crystal structure and substitution effect on antimicrobial activity

Hadi Kargar et al.

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Oxovanadium and dioxomolybdenum complexes: synthesis, crystal structure, spectroscopic characterization and applications as homogeneous catalysts in sulfoxidation

Hadi Kargar et al.

Summary: New oxovanadium and dioxomolybdenum Schiff base complexes were synthesized and characterized by various analytical techniques. Distorted octahedral geometry around the central metal ions was observed in both complexes as revealed by X-ray diffraction studies.

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Synthesis, spectral characterization, crystal structure determination and antimicrobial activity of Ni(II), Cu(II) and Zn(II) complexes with the Schiff base ligand derived from 3,5-dibromosalicylaldehyde

Hadi Kargar et al.

Summary: Three new mononuclear metal complexes with Salen-type tetradentate Schiff base ligand have been synthesized and characterized, showing significant antibacterial activities against various bacterial strains. Nickel and copper complexes have monoclinic crystal system, while zinc complex has orthorhombic crystal system, all with specific coordination geometries.

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Synthesis, crystal structure, theoretical calculation, spectroscopic and antibacterial activity studies of copper(II) complexes bearing bidentate schiffbase ligands derived from 4-aminoantipyrine: Influence of substitutions on antibacterial activity

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Summary: A series of novel Cu(II) complexes with four bis-N,O-bidentate Schiffbase ligands were synthesized and characterized. The crystal structures of some complexes were determined by single crystal X-ray analysis, confirming the coordination mode. Theoretical calculations and biological activity evaluation showed promising results for potential antimicrobial agents.

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Selective oxidation of benzyl alcohols to benzaldehydes catalyzed by dioxomolybdenum Schiff base complex: synthesis, spectral characterization, crystal structure, theoretical and computational studies

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