4.7 Article

Polymeric encapsulation of anti-larval essential oil nanoemulsion for controlled release of bioactive compounds

期刊

INORGANIC CHEMISTRY COMMUNICATIONS
卷 150, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.inoche.2023.110507

关键词

Lemongrass Essential oil; Nanoemulsion; Encapsulation; Controlled release; Chitosan

向作者/读者索取更多资源

Polymeric encapsulation of lemongrass oil nanoemulsion was performed to achieve controlled release of bioactive compounds. The nanoemulsion was prepared from lemongrass essential oil, polysorbate 80, and water. The optimized nanoemulsion was encapsulated with chitosan polymer through cross-linking using glutaraldehyde. The encapsulated lemongrass oil showed better larvicidal activity against malaria vectors due to controlled release of bioactive components.
In the present study, polymeric encapsulation of lemongrass oil nanoemulsion was done for the controlled release of bioactive compounds. O/W nanoemulsion was prepared from lemongrass essential oil, non-ionic surfactant polysorbate80 and water by spontaneous emulsification method. Geranial and neral were found to be the major bioactive compounds, constituting 45.1 % and 31.1 % of total lemongrass essential oil. The optimized lemongrass oil nanoemulsion was formulated with the droplet diameter of 14.4 nm and polydispersity index of 0.111. Transmission electron micrographs revealed that the nanoemulsion droplets were spherical in morphology and were in the size range of 10-100 nm. The optimized nanoemulsion was encapsulated with chitosan polymer by using glutaraldehyde as a cross-linking agent. Encapsulation of essential oil nanoemulsion was optimized for the process parameters such as chitosan concentration and nanoemulsion concentration in order to obtain applicable encapsulation with enhanced release of lemongrass oil. The essential oil-loaded microcapsules were spherical and smooth in shape as revealed by phase contrast microscopy and scanning electron microscopy (SEM) with the diameter of 0.53 +/- 0.02 mm. Mosquito larvicidal activity of encapsulated essential oil nanoemulsion was better against malaria vectors Anopheles stephensi and Anopheles culicifacies when compared to non-encapsulated nanoemulsion, due to the controlled release of the bioactive components. The results of this study will be helpful for future vector control strategies as we provided a practical combined technique of nanoemulsion formulation and polymeric encapsulation as potential delivery system of hydrophobic bioactive compounds against mosquito vector.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据