4.5 Review

Neutrophil sub-types in maintaining immune homeostasis during steady state, infections and sterile inflammation

期刊

INFLAMMATION RESEARCH
卷 72, 期 6, 页码 1175-1192

出版社

SPRINGER BASEL AG
DOI: 10.1007/s00011-023-01737-9

关键词

Neutrophils; Granulopoiesis; Heterogeneity; Auto immune diseases; Infections

向作者/读者索取更多资源

This review summarizes various studies on the heterogeneous nature of neutrophils and their associated functions in steady state and pathological conditions. Recent advances in high throughput technologies have revealed the existence of functionally diverse subsets of neutrophils in bone marrow, blood, and tissues. The proportions of these subsets significantly vary in pathological conditions, and specific signaling pathways in neutrophils have been identified.
IntroductionNeutrophils are component of innate immune system and a) eliminate pathogens b) maintain immune homeostasis by regulating other immune cells and c) contribute to the resolution of inflammation. Neutrophil mediated inflammation has been described in pathogenesis of various diseases. This indicates neutrophils do not represent homogeneous population but perform multiple functions through confined subsets. Hence, in the present review we summarize various studies describing the heterogeneous nature of neutrophils and associated functions during steady state and pathological conditions.MethodologyWe performed extensive literature review with key words 'Neutrophil subpopulations' 'Neutrophil subsets', Neutrophil and infections', 'Neutrophil and metabolic disorders', 'Neutrophil heterogeneity' in PUBMED.ResultsNeutrophil subtypes are characterized based on buoyancy, cell surface markers, localization and maturity. Recent advances in high throughput technologies indicate the existence of functionally diverse subsets of neutrophils in bone marrow, blood and tissues in both steady state and pathological conditions. Further, we found proportions of these subsets significantly vary in pathological conditions. Interestingly, stimulus specific activation of signalling pathways in neutrophils have been demonstrated.ConclusionNeutrophil sub-populations differ among diseases and hence, mechanisms regulating formation, sustenance, proportions and functions of these sub-types vary between physiological and pathological conditions. Hence, mechanistic insights of neutrophil subsets in disease specific manner may facilitate development of neutrophil-targeted therapies.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据