期刊
INFECTION GENETICS AND EVOLUTION
卷 108, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.meegid.2022.105399
关键词
Bats-borne viruses; Coronaviruses; MERS; Zoonotic diseases; Molecular detection
Bats serve as reservoirs for highly contagious and pathogenic viral families. Recent spillover events of viral species from bats, such as SARS-CoV, MERS-CoV and SARS-CoV2, have caused severe outbreaks. Detecting and studying these viral species in bats is crucial for early pandemic potential identification.
Bats remains as reservoirs for highly contagious and pathogenic viral families including the Coronaviridae, Filoviridae, Paramyxoviruses, and Rhabdoviridae. Spill over of viral species (SARS-CoV, MERS-CoV & SARS-CoV2) from bats (as a possible potential reservoirs) have recently caused worst outbreaks. Early detection of viral species of pandemic potential in bats is of great importance. We detected beta coronaviruses in the studied bats population (positive samples from Rousettus leschenaultia) and performed the evolutionary analysis, amino acid sequence alignment, and analysed the 3-Dimentional protein structure. We detected the coronaviruses for the first time in bats from Pakistan. Our analysis based on RdRp partial gene sequencing suggest that the studied viral strains are closely related to MERS-CoV-like viruses as they exhibit close structure similarities (with few sub-stitutions) and also observed a substitution in highly conserved SDD in the palm subdomain of motif C to ADD, when compared with earlier reported viral strains. It could be concluded from our study that coronaviruses are circulating among the bat's population in Pakistan. Based on the current findings, we suggest large scale screening procedures of bat virome across the country to detect potential pathogenic viral species.
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