Monocyte chemokine receptors as therapeutic targets in cardiovascular diseases

Chemokine receptors are fundamental in many processes related to cardiovascular diseases, such as monocyte migration to vessel walls, cell adhesion, and angiogenesis, among others. Even though many experimental studies have shown the utility of blocking these receptors or their ligands in the treatment of atherosclerosis, the findings in clinical research are still poor. Thus, in the current review we aimed to describe some promising results concerning the blockade of chemokine receptors as therapeutic targets in the treatment of cardiovascular diseases and also to discuss some challenges that need to be overcome before using these strategies in clinical practice.

Automated summary

Chemokine receptors play a fundamental role in various processes related to cardiovascular diseases, but the translation of experimental studies to clinical applications remains challenging. This review explores promising results and discusses obstacles that need to be overcome before utilizing chemokine receptor blockade as a therapeutic target in cardiovascular disease treatment.