期刊
IMMUNOLOGY
卷 169, 期 3, 页码 245-259出版社
WILEY
DOI: 10.1111/imm.13633
关键词
apoptosis; cancer; caspase-6; necroptosis; PANoptosis; pyroptosis
类别
Caspase-6, a member of the caspase family, plays a vital role in mediating cell death. Recent studies have shown that it mediates PANoptosis and is involved in tumorigenesis and anti-tumor immunity. Understanding the function of caspase-6 in PANoptosis is important for cancer prevention and treatment.
Cysteinyl aspartate specific proteinase (caspase)-6 belongs to the caspase family and plays a vital role in mediating cell death. Under certain conditions, three pathways of programmed cell death (PCD), including apoptosis, necroptosis and pyroptosis (PANoptosis), transform one way into another, with enormous therapeutic potential. Initially, scholars reported that caspase-6 is a caspase executor that mediates apoptosis. With the ceaseless exploration of the PCD types, studies have demonstrated that caspase-6 mediates pyroptosis by regulating gasdermin D and mediates necroptosis by regulating mixed lineage kinase domain-like. By regulating PANoptosis, caspase-6 plays a crucial role in tumorigenesis in humans and mediates anti-tumour immunity. Therefore, a comprehensive understanding of caspase-6 function in cancer via PANoptosis is important for the prevention and therapy of tumours. This article summarized the function of caspase-6 in PANoptosis and its impact on cancer development, providing targets and strategies for tumour treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据