IL-37 alleviates TNF-α-induced pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes by inhibiting the NF-κB/GSDMD signaling pathway

Article Allergy

IL-37 regulates allergic inflammation by counterbalancing pro-inflammatory IL-1 and IL-33

Alexandra Schroeder et al.

Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.

ALLERGY (2022)

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Article Cell Biology

A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics

Xin Peng et al.

Summary: A20 attenuates pyroptosis and apoptosis of NP cells by promoting mitophagy and stabilizing mitochondrial dynamics. It also reduces LPS-induced NP cell apoptosis by inhibiting NLRP3 inflammasome-mediated pyroptosis.

INFLAMMATION RESEARCH (2022)

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Article Rheumatology

Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor-Induced Caspase 3/Gasdermin E-Mediated Pyroptosis

Zeqing Zhai et al.

Summary: This study investigated the role of GSDME-mediated pyroptosis in the pathogenesis and progression of rheumatoid arthritis (RA). It was found that GSDME plays a pathogenic role in RA and TNF can induce pyroptosis in monocytes and macrophages by activating the caspase 3/GSDME pathway. Targeting GSDME may be a potential therapeutic approach for RA.

ARTHRITIS & RHEUMATOLOGY (2022)

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Article Cell Biology

A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol β deficiency

Lili Gu et al.

Summary: This study reveals the crucial role of DNA polymerase beta in rheumatoid arthritis pathogenesis and provides a detailed explanation for the induction of macrophage pyroptosis through the STING-NF-kappa B pathway.

CELL DEATH & DISEASE (2022)

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Article Gastroenterology & Hepatology

IL-37d Negatively Regulates NLRP3 Transcription via Receptor-mediated Pathway and Alleviates DSS-induced Colitis

Yuan Li et al.

Summary: IL-37d inhibits the overactivation of NLRP3 inflammasome by suppressing NF-κB activation, thereby reducing the expression of NLRP3 at the priming step, which ultimately leads to resistance against colitis.

INFLAMMATORY BOWEL DISEASES (2021)

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Article Immunology

Extracellular and nuclear roles of IL-37 after spinal cord injury

Jesus Amo-Aparicio et al.

Summary: The study showed that IL-37 exerts protective effects as an extracellular cytokine by activating receptors in the context of spinal cord injury (SCI), and translocation to the nucleus is not necessary for its beneficial actions post-injury. Further experiments demonstrated that the therapeutic effects of IL-37 protein rely on the presence of the extracellular receptor IL-1R8, emphasizing the importance of IL-37 extracellular signaling in mediating neuroprotective actions after SCI.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Oncology

Extracellular IL-37 promotes osteogenic and odontogenic differentiation of human dental pulp stem cells via autophagy

Na Li et al.

Summary: IL-37 enhances the osteogenic and odontogenic differentiation ability of dental pulp stem cells (DPSCs) without affecting their proliferation, and also activates cell autophagy. Activation of autophagy promotes osteogenesis and odontogenesis of DPSCs, while inhibition of autophagy suppresses their differentiation.

EXPERIMENTAL CELL RESEARCH (2021)

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Review Immunology

An Overview of the NF-kB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-kB ligand RANKL and related nutritional interventions

Desislava (Daisy) Ilchovska et al.

Summary: NF-kB and RANKL play important roles in RA, with potential side effects from long-term non-specific suppression of the NF-kB pathway. Vitamin D supplementation may help to lower RANKL levels, serving as a potential nutrition intervention for RA management.

AUTOIMMUNITY REVIEWS (2021)

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Review Immunology

Apoptosis, Autophagy, NETosis, Necroptosis, and Pyroptosis Mediated Programmed Cell Death as Targets for Innovative Therapy in Rheumatoid Arthritis

Jianan Zhao et al.

Summary: Rheumatoid arthritis is a chronic inflammatory joint disease characterized by chronic synovial inflammation and degeneration of bones and joints. Despite the variety of treatment options available, some patients still have a poor prognosis due to the complex mechanism of the disease. Programmed cell death has been identified as one of the essential pathological mechanisms of RA, contributing to its development through dysregulation in various cell types.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

LPS induces fibroblast-like synoviocytes RSC-364 cells to pyroptosis through NF-κB mediated dual signalling pathway

Panpan Yang et al.

Summary: Rheumatoid arthritis is a chronic, progressive, and systemic inflammatory joint disease. Synovitis may be associated with pyroptosis, which could be triggered during the occurrence of RA.

JOURNAL OF MOLECULAR HISTOLOGY (2021)

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Article Gastroenterology & Hepatology

IL-37d Negatively Regulates NLRP3 Transcription via Receptor-mediated Pathway and Alleviates DSS-induced Colitis

Yuan Li et al.

Summary: IL-37d inhibits the overactivation of NLRP3 inflammasome through regulating NLRP3 transcription in macrophages, mediated by IL-1R8 receptor signaling pathway, and alleviates DSS-induced colitis.

INFLAMMATORY BOWEL DISEASES (2021)

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Article Immunology