In this study, the researchers found that cytosolic LPS activates the NLRP3 inflammasome through a mechanism involving gasdermin D (GSDMD). They also identified the orphan nuclear receptor Nur77 as a mediator of NLRP3 activation, which senses LPS and GSDMD-dependent accumulation of cytosolic mtDNA.
Cytosolic LPS activates the NLRP3 inflammasome via a gasdermin D (GSDMD)-dependent mechanism. In this issue of Immunity, Zhu et al.(1) provide insight into the events linking these two steps, identifying the orphan nuclear receptor Nur77 as a mediator of NLRP3 activation that senses LPS and GSDMD-dependent accumulation of cytosolic mtDNA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据