Folate and cardiovascular disease

Article Nutrition & Dietetics

Associations of Serum Folate and Homocysteine Concentrations with All-Cause, Cardiovascular Disease, and Cancer Mortality in Men and Women in Korea: the Cardiovascular Disease Association Study

Sihan Song et al.

Summary: This study examined the associations between serum folate and homocysteine concentrations and the risk of all-cause, CVD, and cancer mortality in Korean adults. The findings suggest that higher serum homocysteine and lower serum folate concentrations are associated with an increased risk of all-cause, CVD, and cancer-related mortality.

JOURNAL OF NUTRITION (2023)

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Article Peripheral Vascular Disease

Non-linear associations of serum and red blood cell folate with risk of cardiovascular and all-cause mortality in hypertensive adults

Jing Xu et al.

Summary: This study aims to assess the associations between serum and red blood cell folate levels and cardiovascular and all-cause mortality in hypertensive adults. The findings suggest non-linear associations between serum and RBC folate levels and the risk of cardiovascular and all-cause mortality in hypertensive adults.

HYPERTENSION RESEARCH (2023)

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Article Medicine, General & Internal

Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes

Yujie Liu et al.

Summary: This prospective cohort study found that both low and high serum levels of vitamin B-12 as well as low serum levels of folate were significantly associated with higher risk of cardiovascular disease mortality among individuals with type 2 diabetes.

JAMA NETWORK OPEN (2022)

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Article Nutrition & Dietetics

Associations of Serum and Red Blood Cell Folate With All-Cause and Cardiovascular Mortality Among Hypertensive Patients With Elevated Homocysteine

Long Zhou et al.

Summary: This study found that elevated levels of red blood cell folate are associated with an increased risk of cardiovascular mortality among hypertensive patients with elevated homocysteine, while serum folate has no such effects.

FRONTIERS IN NUTRITION (2022)

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Review Biochemistry & Molecular Biology

Hyperhomocysteinemia and Cardiovascular Disease: Is the Adenosinergic System the Missing Link?

Franck Paganelli et al.

Summary: The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. While HHCy is associated with inflammation and atherosclerosis, lowering homocysteine (HCy) levels does not significantly impact cardiovascular risk. However, the HCy degradation product hydrogen sulfide (H2S) may play a cardioprotective role in the cardiovascular system.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Nutrition & Dietetics