4.1 Article

CircRTN1 stimulates HMGB1 to regulate the malignant progression of papillary thyroid cancer by sponging miR-101-3p

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Peripheral Vascular Disease

Peritumoral B cells drive proangiogenic responses in HMGB1-enriched esophageal squamous cell carcinoma

Ngar Woon Kam et al.

Summary: Different functions and profiles of B-cell subsets in various cancers have been reported. In esophageal squamous cell carcinoma (ESCC), proliferating B cells are predominantly found in the peritumoral region with high expression of HMGB1. Cancer-derived HMGB1 modulates B cells to promote angiogenesis in ESCC microenvironment.

ANGIOGENESIS (2022)

Article Biochemistry & Molecular Biology

Evaluation of recurrence risk in patients with papillary thyroid cancer through tumor-node- metastasis staging: A single-center observational study in Taiwan

Jui-Hung Sun et al.

Summary: This study retrospectively analyzed 829 patients with papillary thyroid cancer and found significant differences in recurrence rate and mortality rate between early and advanced TNM stages. The major impact factors on tumor recurrence in early TNM stage were distant metastasis and lymph node metastasis, while in advanced TNM stage were distant metastasis, male gender, total thyroidectomy with limited lymph node dissection, and a high serum Tg level.

BIOMEDICAL JOURNAL (2022)

Article Oncology

circ_0067934 promotes the progression of papillary thyroid carcinoma cells through miR-1301-3p/HMGB1 axis

Liang-Peng Dong et al.

Summary: The study found that circ_0067934 was upregulated in PTC tissues and cell lines, and its knockdown inhibited the growth, migration, invasion, and induced apoptosis of PTC cells. It was found that circ_0067934 acted as a molecular sponge for miR-1301-3p, inhibiting HMGB1 expression and PI3K/Akt and MAPK activation. circ_0067934 may serve as a prognostic marker or therapeutic target for PTC treatment.

NEOPLASMA (2022)

Article Biochemistry & Molecular Biology

LncRNA XIST Promotes Migration and Invasion of Papillary Thyroid Cancer Cell by Modulating MiR-101-3p/CLDN1 Axis

Yong-Liang Du et al.

Summary: In papillary thyroid carcinoma (PTC), the long non-coding RNA XIST is upregulated and promotes migration and invasion of PTC cells by directly regulating the miR-101-3p/CLDN1 axis. This study provides a novel mechanistic insight into the role of XIST in PTC metastasis.

BIOCHEMICAL GENETICS (2021)

Article Biotechnology & Applied Microbiology

Circular RNA 0081146 facilitates the progression of gastric cancer by sponging miR-144 and up-regulating HMGB1

Qihua Xu et al.

Summary: The study reveals that circ_0081146 is upregulated in gastric cancer and acts as an oncogene by promoting cell growth, migration, and invasion through modulating the miR-144/HMGB1 axis.

BIOTECHNOLOGY LETTERS (2021)

Article Cell Biology

Circ-CSPP1 knockdown suppresses hepatocellular carcinoma progression through miR-493-5p releasing-mediated HMGB1 downregulation

Ganghua Yang et al.

Summary: This study demonstrated the crucial role of circ-CSPP1 in hepatocellular carcinoma (HCC) by regulating the expression of miR-493-5p and HMGB1, thereby suppressing HCC development both in vitro and in vivo.

CELLULAR SIGNALLING (2021)

Review Biochemistry & Molecular Biology

Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies

Sumeng Wang et al.

Summary: Cancer is a major cause of death worldwide, prompting research into novel biomarkers for diagnosis. Circulating circRNAs, stably present in body fluids, exhibit distinct expression patterns that can be used to monitor cancer development and progression.

MOLECULAR CANCER (2021)

Review Endocrinology & Metabolism

Current practice in patients with differentiated thyroid cancer

Martin Schlumberger et al.

Summary: Considerable changes have occurred in the management of differentiated thyroid cancer (DTC) over the past four decades, with improved diagnostic tools and prognostic classifications available. Low-risk patients make up the majority with good outcomes, while high-risk patients require more aggressive treatment and follow-up due to frequent recurrences.

NATURE REVIEWS ENDOCRINOLOGY (2021)

Article Oncology

Circular RNA hsa_circ_0001666 sponges miR-330-5p, miR-193a-5p and miR-326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4

Ying Qi et al.

Summary: The study revealed that upregulated circular RNA hsa_circ_0001666 in papillary thyroid carcinoma (PTC) is associated with lymph node metastasis and promotes cancer aggressiveness. Knocking down hsa_circ_0001666 inhibits cell proliferation and induces apoptosis in PTC. Furthermore, hsa_circ_0001666 promotes PTC tumorigenesis through the miR-330-5p/miR-193a-5p/miR-326/ETV4 pathway, suggesting its potential as a therapeutic target for PTC.

ONCOLOGY REPORTS (2021)

Article Medicine, Research & Experimental

HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer

Jianming Lu et al.

Summary: This study demonstrated the biological relevance of circCSPP1 and HnRNP-L in the progression of prostate cancer, indicating that increased circCSPP1 in prostate cancer cells regulated by HnRNP-L can induce autophagy, leading to enhanced proliferation, migration, and invasion. Furthermore, a potential competing endogenous RNA network involving circCSPP1, miR-520h, and EGR1 was revealed in prostate cancer cells, suggesting its significance in prostate cancer progression.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Article Endocrinology & Metabolism

Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma

Yichao Wang et al.

Summary: This study identified C4A and PLG in serum as potential biomarkers for predicting PTC, with high sensitivity and specificity. The AUC for C4A and PLG were 0.97 +/- 0.02 and 0.89 +/- 0.05, indicating their strong diagnostic value for PTC.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Oncology

CircANTXR1 Contributes to the Malignant Progression of Hepatocellular Carcinoma by Promoting Proliferation and Metastasis

Changshan Huang et al.

Summary: The study revealed that circANTXR1 is a stable and highly expressed circRNA in HCC, promoting the progression of HCC through the miR-532-5p/XRCC5 axis. CircANTXR1 may serve as a potential serum biomarker and therapeutic target for HCC patients.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

Article Biochemistry & Molecular Biology

CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis

Min Li et al.

Summary: The study demonstrates the regulatory relationship between circPTK2, miR-181c-5p, and HMGB1 in microglia and sepsis mice. HMGB1 and circPTK2 were upregulated, while miR-181c-5p was downregulated in response to LPS induction in microglia. Targeting circPTK2/miR-181c-5p/HMGB1 signaling pathway may offer potential therapeutic targets for sepsis-induced cognitive dysfunction and neuronal apoptosis.

MOLECULAR MEDICINE (2021)

Review Oncology

Circular RNAs: characteristics, biogenesis, mechanisms and functions in liver cancer

Hao Shen et al.

Summary: Circular RNAs (circRNAs) are a novel class of noncoding RNAs that play a significant role in the initiation and progression of HCC, but their internal mechanisms and clinical applications require further investigation.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Review Surgery

Clinicopathological Significance of Papillary Thyroid Carcinoma Located in the Isthmus: A Meta-Analysis

Young Sang Lyu et al.

Summary: The meta-analysis found that there was no significant difference in lymphovascular invasion between isthmus PTC and PTC at other sites, but isthmus PTC had a higher risk of central lymph node metastasis and a slightly higher recurrence rate compared to PTC at other sites.

WORLD JOURNAL OF SURGERY (2021)

Article Mathematical & Computational Biology

Five genes involved in circular RNA-associated competitive endogenous RNA network correlates with metastasis in papillary thyroid carcinoma

Jie Qiu et al.

Summary: This study identified potential circRNAs, miRNAs, and mRNAs in papillary thyroid carcinoma through multiomics analysis, revealing their regulatory networks. Key genes were found to be associated with patient prognosis and clinical characteristics, with LPAR5 potentially affecting patient survival and other genes potentially correlated with PTC metastasis.

MATHEMATICAL BIOSCIENCES AND ENGINEERING (2021)

Article Oncology

MiR-101-3p Suppresses Progression of Cervical Squamous Cell Carcinoma by Targeting and Down-Regulating KPNA2

Hong Wang et al.

Summary: The study revealed that in cervical squamous cell carcinoma, microRNA-101-3p is lowly expressed while KPNA2 is highly expressed, with a direct targeting relationship between the two. The microRNA-101-3p/KPNA2 axis can suppress the growth of cervical squamous cell carcinoma by targeting KPNA2.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

Review Biochemistry & Molecular Biology

Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression

Chen Xue et al.

Summary: Circular RNAs (circRNAs) are covalently closed noncoding RNAs that regulate target gene expression and play important roles in cancer progression through the circRNA/PI3K/AKT axis. Aberrant regulation of circRNA expression is significantly associated with clinicopathological characteristics and plays crucial roles in biological functions.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Biochemistry & Molecular Biology

Multikinase Inhibitor Treatment in Thyroid Cancer

Ole Vincent Ancker et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Editorial Material Endocrinology & Metabolism

Therapeutic breakthroughs for metastatic thyroid cancer

Vera Tiedje et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

Article Medicine, Research & Experimental

MiR-let-7e inhibits invasion and magration and regulates HMGB1 expression in papillary thyroid carcinoma

Chao Ding et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Review Genetics & Heredity

The biogenesis, biology and characterization of circular RNAs

Lasse S. Kristensen et al.

NATURE REVIEWS GENETICS (2019)

Review Biochemistry & Molecular Biology

Circular RNAs function as ceRNAs to regulate and control human cancer progression

Yaxian Zhong et al.

MOLECULAR CANCER (2018)

Review Oncology

Function and clinical significance of circRNAs in solid tumors

Yiting Geng et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Review Biochemistry & Molecular Biology

Flavonoids, Thyroid Iodide Uptake and Thyroid Cancer-A Review

Carlos E. L. Goncalves et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Endocrinology & Metabolism

Epigenetic Modifications: Novel Therapeutic Approach for Thyroid Cancer

Xuguang Zhu et al.

ENDOCRINOLOGY AND METABOLISM (2017)

Review Medicine, General & Internal

Thyroid cancer

Maria E. Cabanillas et al.

LANCET (2016)

Review Genetics & Heredity

NON-CODING RNA Towards a molecular understanding of microRNA-mediated gene silencing

Stefanie Jonas et al.

NATURE REVIEWS GENETICS (2015)