Letter to the Editor: Is lifestyle modification effective for individuals with high fibrosis-4 index without an additional second-tier test?

Summary: This study aimed to determine the cost-effectiveness of combination testing involving VCTE versus MRE as a frontline imaging strategy for NAFLD patients with advanced fibrosis. The results showed that MRE was not only more cost-effective than VCTE but also remained cost-effective when used as a follow-up in instances of VCTE failure to diagnose.