☆ 4.8 Article

AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma

HEPATOLOGY (2023)

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HEPATOLOGY (2021)

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Trial Design and Endpoints in Hepatocellular Carcinoma: AASLD Consensus Conference

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Patient-Reported Barriers Are Associated With Receipt of Hepatocellular Carcinoma Surveillance in a Multicenter Cohort of Patients With Cirrhosis

Amit G. Singal et al.

Summary: The study found that patient-reported barriers such as knowledge deficits, costs, difficulty scheduling, and transportation significantly impact less frequent receipt of HCC surveillance. This indicates a need for patient-centered interventions, such as patient navigation.

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A novel model for predicting posthepatectomy liver failure based on liver function and degree of liver resection in patients with hepatocellular carcinoma

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HPB (2021)

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Proton beam radiotherapy vs. radiofrequency ablation for recurrent hepatocellular carcinoma: A randomized phase III trial

Tae Hyun Kim et al.

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Letter Surgery

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Small single perivascular hepatocellular carcinoma: comparisons of radiofrequency ablation and microwave ablation by using propensity score analysis

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Francis Y. Yao et al.

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Personalised versus standard dosimetry approach of selective internal radiation therapy in patients with locally advanced hepatocellular carcinoma (DOSISPHERE-01): a randomised, multicentre, open-label phase 2 trial

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Diagnostic efficacy of contrast-enhanced ultrasound versus MRI Liver Imaging Reporting and Data System (LI-RADS) for categorising hepatic observations in patients at risk of hepatocellular carcinoma

S. Li et al.

Summary: The study found that the CEUS LI-RADS scheme is an effective diagnostic tool for HCC with substantial intra-observer reliability. The diagnostic performance of CEUS LI-RADS for determining HCC was comparable to MRI LI-RADS, and the specificity of CEUS LR-5 was significantly higher.

CLINICAL RADIOLOGY (2021)

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Article Gastroenterology & Hepatology

International Liver Cancer Association (ILCA) White Paper on Biomarker Development for Hepatocellular Carcinoma

Amit G. Singal et al.

GASTROENTEROLOGY (2021)

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Review Gastroenterology & Hepatology

Abbreviated MRI for hepatocellular carcinoma screening: A systematic review and meta-analysis

Pankaj Gupta et al.

Summary: Abbreviated MRI (AMRI) is suggested as an alternative for hepatocellular carcinoma (HCC) screening. Our study showed that AMRI has high sensitivity and specificity for HCC screening. Different AMRI protocols have comparable diagnostic performance.

JOURNAL OF HEPATOLOGY (2021)

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Article Oncology

Postoperative imaging surveillance for hepatocellular carcinoma: How much is enough?

Rayyan S. Mirdad et al.

Summary: The study found that usage of high-intensity surveillance imaging decreased over time following liver-directed therapy for HCC, and that the intensity of surveillance did not have any impact on long-term survival.

JOURNAL OF SURGICAL ONCOLOGY (2021)

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Article Gastroenterology & Hepatology

Comparison of preoperative two-dimensional shear wave elastography, indocyanine green clearance test and biomarkers for post hepatectomy liver failure prediction in patients with hepatocellular carcinoma

Rong Fu et al.

Summary: In patients with hepatocellular carcinoma, liver stiffness value measured by 2D-SWE may demonstrate better efficacy for preoperative prediction of post hepatectomy liver failure compared to ICG-R15 and ALBI scores.

BMC GASTROENTEROLOGY (2021)

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Review Gastroenterology & Hepatology

AGA Clinical Practice Update on Palliative Care Management in Cirrhosis: Expert Review

Puneeta Tandon et al.

Summary: Palliative Care is an approach focusing on improving the quality of life for patients facing life-limiting illness, applicable in cirrhosis patients. However, there is limited guidance and promotion of PC in patients with cirrhosis.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

State-Level HCC Incidence and Association With Obesity and Physical Activity in the United States

Yi-Te Lee et al.

Summary: This study identified wide state-level racial/ethnic disparities in HCC incidence, with over half of the states experiencing increasing rates. Additionally, there were moderate correlations between HCC incidence trends and state-level obesity as well as lack of physical activity, suggesting interventions targeting these factors may help curb rising HCC incidence.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Yttrium-90 Radioembolization for the Treatment of Solitary, Unresectable HCC: The LEGACY Study

Riad Salem et al.

Summary: The LEGACY study evaluated the efficacy of yttrium-90 glass microspheres in treating solitary, unresectable HCC <= 8 cm, showing promising response rates and durable responses in a multicenter setting.

HEPATOLOGY (2021)

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Article Oncology

Cancer statistics for the year 2020: An overview

Jacques Ferlay et al.

Summary: The study briefly reviews the methods and data sources used in compiling the IARC GLOBOCAN cancer statistics for 2020 and summarizes the main results. It estimated that there were nearly 19.3 million new cancer cases and almost 10 million cancer deaths worldwide in 2020, with the most commonly diagnosed cancers being female breast cancer and lung cancer, and the most common causes of cancer death being lung cancer and liver cancer.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Multicenter Evaluation of Survival and Toxicities of Hepatocellular Carcinoma following Radioembolization: Analysis of the RESiN Registry

Shelby Frantz et al.

Summary: The study aimed to determine overall survival (OS), progression-free survival (PFS), and toxicity in hepatocellular carcinoma (HCC) patients using transarterial radioembolization (TARE) with resin microspheres in a multicenter, real-world data registry. The results showed that TARE provided comparable OS to other studies in this frequently pretreated patient cohort with disease burden in 81% beyond the Milan criteria.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2021)

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Article Surgery

Dynamic α-Fetoprotein Response and Outcomes After Liver Transplant for Hepatocellular Carcinoma

Karim J. Halazun et al.

Summary: This study validates the importance of AFP-R in selecting patients with HCC for liver transplant, showing its accurate prediction of recurrence and overall survival. AFP-R is a truly objective pre-transplant biological characteristic, and its incorporation into selection criteria allows for safe expansion of existing models and offers transplant opportunities to patients with acceptable tumor characteristics who might otherwise be denied potential cure.

JAMA SURGERY (2021)

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Article Oncology

Comparison of Surgical Resection and Systemic Treatment for Hepatocellular Carcinoma with Vascular Invasion: National Cancer Database Analysis

Rajalakshmi Govalan et al.

Summary: The study suggests that surgical resection may provide better outcomes compared to systemic therapy for HCC patients with vascular invasion. Factors such as ethnicity, clinical characteristics, and treating facility type and region were associated with the likelihood of receiving surgical resection.

LIVER CANCER (2021)

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Article Surgery

Liver Venous Deprivation or Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy? A Retrospective Multicentric Study

Alexandre Chebaro et al.

Summary: This study compared the effects of simultaneous portal vein embolization and hepatic vein embolization techniques on remnant liver hypertrophy in candidates for extended hepatectomy, specifically LVD and ALPPS procedures. Results showed that ALPPS led to faster hypertrophy and higher successful resection rates compared to LVD. While LVD had advantages in terms of operative duration, blood losses, and length-of-stay, ALPPS demonstrated potential benefits in patient management.

ANNALS OF SURGERY (2021)

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Article Oncology

Adiposity, Adulthood Weight Change, and Risk of Incident Hepatocellular Carcinoma

Tracey G. Simon et al.

Summary: The study found that individuals with weight gain of less than 10 kg had a lower risk for hepatocellular carcinoma, while those with weight gain of 20 kg or more had a higher risk for the disease.

CANCER PREVENTION RESEARCH (2021)

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Review Gastroenterology & Hepatology

Evidence-Based Management of Hepatocellular Carcinoma: Systematic Review and Meta-analysis of Randomized Controlled Trials (2002-2020)

Philipp K. Haber et al.

Summary: A review of 49 high-quality phase III randomized controlled trials in hepatocellular carcinoma conducted between 2002 and 2020 found that 9 had positive results, suggesting that immunotherapies may be more effective in viral etiologies.

GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Downstaging Outcomes for Hepatocellular Carcinoma: Results From the Multicenter Evaluation of Reduction in Tumor Size before Liver Transplantation (MERITS-LT) Consortium

Neil Mehta et al.

Summary: This study is the first multiregional study based on UNOS-DS criteria, showing a successful downstaging rate of >80% and similar efficacy of chemoembolization and yttrium-90 radioembolization as the initial downstaging treatment. Despite a 2-year post-LT survival rate of 95%, a high rate of tumor understaging was observed.

GASTROENTEROLOGY (2021)

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Review Gastroenterology & Hepatology

Review of Use of Y90 as a Bridge to Liver Resection and Transplantation in Hepatocellular Carcinoma

Motaz Qadan et al.

Summary: Y90 radioembolization has shown a high safety profile and increasing utility in bridging and downstaging HCC patients for liver resection or transplant. Continuous advancements in treatment strategies and radiation dosimetry have paved the way for the incorporation of Y90 in different stages of HCC with various intents.

JOURNAL OF GASTROINTESTINAL SURGERY (2021)

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Article Gastroenterology & Hepatology

Epidemiology and risk-stratification of NAFLD-associated HCC

George N. Ioannou

Summary: NAFLD is projected to be the leading cause of hepatocellular carcinoma and is associated with risk factors such as obesity, diabetes, Hispanic ethnicity, and genetic polymorphisms. Lipotoxicity and oxidative DNA damage may lead to hepatocarcinogenesis, especially in the absence of cirrhosis. Validated models to identify high-risk patients for hepatocellular carcinoma in NAFLD are currently unavailable.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Prevention of NAFLD-associated HCC: Role of lifestyle and chemoprevention

Naomi F. Lange et al.

Summary: This review highlights the increasing burden of hepatocellular carcinoma associated with nonalcoholic fatty liver disease and non-alcoholic steatohepatitis worldwide. Preventive strategies including lifestyle factors and chemopreventive treatments are crucial in combating this trend. The role of adjuvant therapies for tertiary prevention of HCC is briefly reviewed.

JOURNAL OF HEPATOLOGY (2021)

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Article Oncology

Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study

Harriet Rumgay et al.

Summary: Alcohol use is causally linked to multiple cancers globally, with 741,300 new cancer cases attributable to alcohol consumption in 2020. Male accounted for the majority of alcohol-attributable cancer cases, with heavy drinking and risky drinking contributing most to the burden. Regional variations exist in the burden of alcohol-attributable cancers.

LANCET ONCOLOGY (2021)

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Review Gastroenterology & Hepatology

Hepatitis B virus infection and hepatocellular carcinoma in sub-Saharan Africa: Implications for elimination of viral hepatitis by 2030?

Edina Amponsah-Dacosta

Summary: Eliminating viral hepatitis in sub-Saharan Africa by 2030 is challenging due to the high burden of chronic HBV carriers and the risk of HCC. Increasing coverage of HBV vaccination and improving early diagnosis and care for high-risk individuals is crucial in reducing new cases. Without intervention, HCC incidence and mortality rates in the region are projected to double by 2040, highlighting the urgent need for public health attention.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Review Gastroenterology & Hepatology

Outcomes after curative therapy for hepatocellular carcinoma in patients with non-alcoholic fatty liver disease: a meta-analysis and review of current literature

Ken M. Chin et al.

Summary: The study found that NAFLD-HCC patients undergoing curative therapy, such as liver resection, had improved disease-free survival and overall survival compared to non-NAFLD HCC patients. However, there were higher rates of peri-and post-operative complications reported in NAFLD-HCC patients, and significant inter-study heterogeneity limited further analysis.

HPB (2021)

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Article Gastroenterology & Hepatology

Non-invasive imaging criteria for the diagnosis of hepatocellular carcinoma in non-cirrhotic patients with chronic hepatitis B

Carlos Moctezuma-Velazquez et al.

Summary: The study evaluated the performance of EASL and LI-RADS criteria for diagnosing HCC in non-cirrhotic patients with chronic HBV infection. The criteria showed a positive predictive value comparable to that seen in patients with cirrhosis when the pre-test probability of HCC is >70%. These criteria could be used for diagnosing HCC in non-cirrhotic patients with HBV.

JHEP REPORTS (2021)

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Article Oncology

Neoadjuvant cabozantinib and nivolumab convert locally advanced hepatocellular carcinoma into resectable disease with enhanced antitumor immunity

Won Jin Ho et al.

Summary: A study evaluating neoadjuvant cabozantinib and nivolumab in patients with hepatocellular carcinoma (HCC) showed that 80% of patients successfully underwent hepatic resection surgery, with 42% having major pathological responses. An in-depth biospecimen profiling indicated an orchestrated contribution of B cells to antitumor immunity in HCC, with effector T cells, tertiary lymphoid structures, CD138(+) plasma cells, and a distinct spatial arrangement of B cells being enriched in responders compared to nonresponders.

NATURE CANCER (2021)

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Article Gastroenterology & Hepatology

Liver resection for hepatocellular carcinoma in patients with clinically significant portal hypertension

Daniel Azoulay et al.

Summary: In highly specialised liver centres, patients with cirrhosis, hepatocellular carcinoma, and HVPG >= 10 mmHg can undergo liver resection with acceptable mortality, morbidity, and liver decompensation rates. The laparoscopic approach is the sole predictor of achieving a textbook outcome.

JHEP REPORTS (2021)

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Article Surgery

Laparoscopic and open liver resection for hepatocellular carcinoma with Child-Pugh B cirrhosis: multicentre propensity score-matched study

R. Troisi et al.

Summary: For patients with Child-Pugh B cirrhosis undergoing liver resection for HCC, laparoscopic surgery is associated with lower blood loss, lower morbidity, and shorter hospital stay compared to open surgery. However, the 5-year overall and disease-free survival rates do not significantly differ between the two approaches. Patients without preoperative portal hypertension and Child-Pugh B7 cirrhosis may benefit most from laparoscopic liver surgery.

BRITISH JOURNAL OF SURGERY (2021)

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Article Oncology

Preoperative Portal Vein Embolization for Liver Resection: An updated meta-analysis

Yu Huang et al.

Summary: Portal vein embolization (PVE) is a safe and effective procedure for inducing liver volume remnant increase in liver tumor patients, which can elevate the resection rate. Careful patient cohort selection is crucial to avoid overuse of PVE. Further central clinical trials are needed to provide guidelines for surgeons.

JOURNAL OF CANCER (2021)

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Article Gastroenterology & Hepatology

National Experience on Down-Staging of Hepatocellular Carcinoma Before Liver Transplant: Influence of Tumor Burden, Alpha-Fetoprotein, and Wait Time

Neil Mehta et al.

HEPATOLOGY (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Prevalence and clinical significance of discordant LI-RADS (R) observations on multiphase contrast-enhanced MRI in patients with cirrhosis

Takeshi Yokoo et al.

ABDOMINAL RADIOLOGY (2020)

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Review Gastroenterology & Hepatology

Contemporary Epidemiology of Chronic Liver Disease and Cirrhosis

Andrew M. Moon et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2020)

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Article Oncology

International trends in hepatocellular carcinoma incidence, 1978-2012

Jessica L. Petrick et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

A nomogram to predict survival of patients with intermediate-stage hepatocellular carcinoma after transarterial chemoembolization combined with microwave ablation

Jia-yan Ni et al.

EUROPEAN RADIOLOGY (2020)

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Article Gastroenterology & Hepatology

AGA Clinical Practice Update on Screening and Surveillance for Hepatocellular Carcinoma in Patients with Nonalcoholic Fatty Liver Disease: Expert Review

Rohit Loomba et al.

GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

Hepatocellular Carcinoma Demonstrates Heterogeneous Growth Patterns in a Multicenter Cohort of Patients With Cirrhosis

Nicole E. Rich et al.

HEPATOLOGY (2020)

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Article Gastroenterology & Hepatology

Liver Transplantation Outcomes in a US Multicenter Cohort of 789 Patients With Hepatocellular Carcinoma Presenting Beyond Milan Criteria

Ani Kardashian et al.

HEPATOLOGY (2020)

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Article Oncology

Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial

Richard S. Finn et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Gastroenterology & Hepatology

mRECIST for HCC: Performance and novel refinements

Josep M. Llovet et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Immunology

Surveillance for HCC After Liver Transplantation: Increased Monitoring May Yield Aggressive Treatment Options and Improved Postrecurrence Survival

David D. Lee et al.

TRANSPLANTATION (2020)

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Article Oncology

Biomarkers for the Early Detection of Hepatocellular Carcinoma

Neehar D. Parikh et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2020)

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Editorial Material Gastroenterology & Hepatology

Risk Factors for Cirrhosis in Contemporary Hepatology Practices-Findings From the Texas Hepatocellular Carcinoma Consortium Cohort

Hashem B. El-Serag et al.

GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

A nomogram based on liver stiffness predicts postoperative complications in patients with hepatocellular carcinoma

Matteo Serenari et al.

JOURNAL OF HEPATOLOGY (2020)

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Review Oncology

Statin Use and the Risk of Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies

Md. Mohaimenul Islam et al.

CANCERS (2020)

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Article Medicine, General & Internal

Association of Aspirin with Hepatocellular Carcinoma and Liver-Related Mortality

Tracey G. Simon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Gastroenterology & Hepatology

Cost-Effectiveness of Hepatocellular Carcinoma Surveillance: An Assessment of Benefits and Harms

Neehar D. Parikh et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2020)

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Article Oncology

Usefulness of Tumor Tissue Biopsy for Predicting the Biological Behavior of Hepatocellular Carcinoma

Taro Shioga et al.

ANTICANCER RESEARCH (2020)

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Article Oncology

A differential risk assessment and decision model for Transarterial chemoembolization in hepatocellular carcinoma based on hepatic function

Joon Yeul Nam et al.

BMC CANCER (2020)

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Article Oncology

A Comparison of Biannual Two-Phase Low-Dose Liver CT and US for HCC Surveillance in a Group at High Risk of HCC Development

Jeong Hee Yoon et al.

LIVER CANCER (2020)

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Article Gastroenterology & Hepatology

Association of inflammatory biomarkers with clinical outcomes in nivolumab-treated patients with advanced hepatocellular carcinoma

Bruno Sangro et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Surgery

Overall Tumor Burden Dictates Outcomes for Patients Undergoing Resection of Multinodular Hepatocellular Carcinoma Beyond the Milan Criteria

Diamantis Tsilimigras et al.

ANNALS OF SURGERY (2020)

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Article Surgery

mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors

Andreas A. Schnitzbauer et al.

ANNALS OF SURGERY (2020)

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Article Oncology

Liver transplantation in hepatocellular carcinoma after tumour downstaging (XXL): a randomised, controlled, phase 2b/3 trial

Vincenzo Mazzaferro et al.

LANCET ONCOLOGY (2020)

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Article Multidisciplinary Sciences

Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring

Na Sun et al.

NATURE COMMUNICATIONS (2020)

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Review Gastroenterology & Hepatology

Radiation-induced liver disease in the era of SBRT: a review

Carolina De La Pinta Alonso

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Oncology

Efficacy and Safety of Nivolumab Plus Ipilimumab in Patients With Advanced Hepatocellular Carcinoma Previously Treated With Sorafenib The CheckMate 040 Randomized Clinical Trial

Thomas Yau et al.

JAMA ONCOLOGY (2020)

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Review Radiology, Nuclear Medicine & Medical Imaging

TACE combined with microwave a blation therapy vs. TACE alone for treatment of early- and intermediate-stage hepatocellular carcinomas larger than 5 cm: a meta-analysis

Chong Liu et al.

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY (2020)

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Review Gastroenterology & Hepatology

Lifestyle and Environmental Approaches for the Primary Prevention of Hepatocellular Carcinoma

Tracey G. Simon et al.

CLINICS IN LIVER DISEASE (2020)

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Article Gastroenterology & Hepatology

Nonalcoholic Steatohepatitis Is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates

Zobair Younossi et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Primary Care Provider Practice Patterns and Barriers to Hepatocellular Carcinoma Surveillance

Okeefe L. Simmons et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Longitudinal Assessment of Three Serum Biomarkers to Detect Very Early-Stage Hepatocellular Carcinoma

Jonggi Choi et al.

HEPATOLOGY (2019)

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Article Oncology

Long-Term Survival Outcome Between Living Donor and Deceased Donor Liver Transplant for Hepatocellular Carcinoma: Intention-to-Treat and Propensity Score Matching Analyses

Tiffany C. L. Wong et al.

ANNALS OF SURGICAL ONCOLOGY (2019)

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Article Gastroenterology & Hepatology

Are There Upper Limits in Tumor Burden for Down-Staging of Hepatocellular Carcinoma to Liver Transplant? Analysis of the All-Comers Protocol

Jasmine Sinha et al.

HEPATOLOGY (2019)

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Article Multidisciplinary Sciences

Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy

Chunfeng Qu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Gastroenterology & Hepatology

The predictive value of future liver remnant function after liver resection for HCC in noncirrhotic and cirrhotic patients

Elisabeth Bluethner et al.

HPB (2019)

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Meeting Abstract Oncology

A multicenter randomized controlled trial to evaluate the efficacy of surgery vs. radiofrequency ablation for small hepatocellular carcinoma (SURF trial).

Namiki Izumi et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Meeting Abstract Oncology

Phase 3 (COSMIC-312) study of cabozantinib (C) in combination with atezolizumab (A) versus sorafenib (S) in patients (pts) with advanced hepatocellular carcinoma (aHCC) who have not received previous systemic anticancer therapy.

Robin Kate Kelley et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Gastroenterology & Hepatology

Direct-acting antivirals after successful treatment of early hepatocellular carcinoma improve survival in HCV-cirrhotic patients

Giuseppe Cabibbo et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Models estimating risk of hepatocellular carcinoma in patients with alcohol or NAFLD-related cirrhosis for risk stratification

George N. Ioannou et al.

JOURNAL OF HEPATOLOGY (2019)

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Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Role of US LI-RADS in the LI-RADS Algorithm

Shuchi K. Rodgers et al.

RADIOGRAPHICS (2019)

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Article Gastroenterology & Hepatology

Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients With Baseline Cirrhosis or High FIB-4 Scores

George N. Ioannou et al.

GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection Is Associated With Increased Survival in Patients With a History of Hepatocellular Carcinoma

Amit G. Singal et al.

GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

A new ALBI-based model to predict survival after transarterial chemoembolization for BCLC stage B hepatocellular carcinoma

I-Cheng Lee et al.

LIVER INTERNATIONAL (2019)

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Article Oncology

Lenvatinib as an Initial Treatment in Patients with Intermediate-Stage Hepatocellular Carcinoma Beyond Up-To-Seven Criteria and Child-Pugh A Liver Function: A Proof-Of-Concept Study

Masatoshi Kudo et al.

CANCERS (2019)

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Article Medicine, General & Internal

Lipophilic Statins and Risk for Hepatocellular Carcinoma and Death in Patients With Chronic Viral Hepatitis: Results From a Nationwide Swedish Population

Tracey G. Simon et al.

ANNALS OF INTERNAL MEDICINE (2019)

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Review Gastroenterology & Hepatology

Management of patients with hepatocellular carcinoma and portal vein tumour thrombosis: comparing east and west

Jian Lu et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Cost Effectiveness of Hepatocellular Carcinoma Surveillance After a Sustained Virologic Response to Therapy in Patients With Hepatitis C Virus Infection and Advanced Fibrosis

Hooman Farhang Zangneh et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

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Review Gastroenterology & Hepatology

Accuracy of the Liver Imaging Reporting and Data System in Computed Tomography and Magnetic Resonance Image Analysis of Hepatocellular Carcinoma or Overall Malignancy-A Systematic Review

Christian B. van der Pol et al.

GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

Magnetic Resonance Imaging Is Cost-Effective for Hepatocellular Carcinoma Surveillance in High-Risk Patients With Cirrhosis

Hye-Lin Kim et al.

HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

An Eastern Hepatobiliary Surgery Hospital/Portal Vein Tumor Thrombus Scoring System as an Aid to Decision Making on Hepatectomy for Hepatocellular Carcinoma Patients With Portal Vein Tumor Thrombus: A Multicenter Study

Xiu-Ping Zhang et al.

HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Alpha-Fetoprotein Decrease from > 1,000 to < 500 ng/mL in Patients with Hepatocellular Carcinoma Leads to Improved Posttransplant Outcomes

Neil Mehta et al.

HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Live donor liver transplantation for patients with hepatocellular carcinoma offers increased survival vs. deceased donation

Nicolas Goldaracena et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Outcomes of radiofrequency ablation as first-line therapy for hepatocellular carcinoma less than 3 cm in potentially transplantable patients

Adam Doyle et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Gastroenterology & Hepatology

Sorafenib with or without concurrent transarterial chemoembolization in patients with advanced hepatocellular carcinoma: The phase III STAH trial

Joong-Won Park et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Oncology

Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial

Andrew X. Zhu et al.

LANCET ONCOLOGY (2019)

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Article Medicine, General & Internal

Projected US State-Level Prevalence of Adult Obesity and Severe Obesity

Zachary J. Ward et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Y90 Radioembolization Significantly Prolongs Time to Progression Compared With Chemoembolization in Patients With Hepatocellular Carcinoma

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Total tumor volume and alpha-fetoprotein for selection of transplant candidates with hepatocellular carcinoma: A prospective validation

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Serum alpha-fetoprotein level independently predicts posttransplant survival in patients with hepatocellular carcinoma

Kristin Berry et al.

LIVER TRANSPLANTATION (2013)

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Article Gastroenterology & Hepatology

Identification of Liver Transplant Candidates With Hepatocellular Carcinoma and a Very Low Dropout Risk: Implications for the Current Organ Allocation Policy

Neil Mehta et al.

LIVER TRANSPLANTATION (2013)

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Article Surgery

Usefulness of the Kyoto criteria as expanded selection criteria for liver transplantation for hepatocellular carcinoma

Toshimi Kaido et al.

SURGERY (2013)

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Article Surgery

Outcomes of Living and Deceased Donor Liver Transplant Recipients With Hepatocellular Carcinoma: Results of the A2ALL Cohort

L. M. Kulik et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2012)

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Article Gastroenterology & Hepatology

How Much Remnant Is Enough in Liver Resection?

Alfredo Guglielmi et al.

DIGESTIVE SURGERY (2012)

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Article Gastroenterology & Hepatology

Liver Transplantation for Hepatocellular Carcinoma: A Model Including α-Fetoprotein Improves the Performance of Milan Criteria

Christophe Duvoux et al.

GASTROENTEROLOGY (2012)

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Article Gastroenterology & Hepatology

A randomized controlled trial of radiofrequency ablation and surgical resection in the treatment of small hepatocellular carcinoma

Kai Feng et al.

JOURNAL OF HEPATOLOGY (2012)

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Article Gastroenterology & Hepatology

Hepatocelluar nodules in liver cirrhosis: hemodynamic evaluation (angiography-assisted CT) with special reference to multi-step hepatocarcinogenesis

Osamu Matsui et al.

ABDOMINAL IMAGING (2011)

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Review Radiology, Nuclear Medicine & Medical Imaging

Value of PET/CT in the Management of Primary Hepatobiliary Tumors, Part 2

Ari Sacks et al.

AMERICAN JOURNAL OF ROENTGENOLOGY (2011)

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Article Gastroenterology & Hepatology

Management of Hepatocellular Carcinoma in Japan: Consensus-Based Clinical Practice Guidelines Proposed by the Japan Society of Hepatology (JSH) 2010 Updated Version

Masatoshi Kudo et al.

DIGESTIVE DISEASES (2011)

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Article Oncology

Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma

Masatoshi Kudo et al.

EUROPEAN JOURNAL OF CANCER (2011)

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Article Gastroenterology & Hepatology

Diagnostic Accuracy of Clathrin Heavy Chain Staining in a Marker Panel for the Diagnosis of Small Hepatocellular Carcinoma

Luca Di Tommaso et al.

HEPATOLOGY (2011)

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Article Gastroenterology & Hepatology

Ultrasonographic Surveillance of Hepatocellular Carcinoma in Cirrhosis: A Randomized Trial Comparing 3-and 6-Month Periodicities

Jean-Claude Trinchet et al.

HEPATOLOGY (2011)

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Article Gastroenterology & Hepatology

Feasibility of Conducting a Randomized Control Trial for Liver Cancer Screening: Is a Randomized Controlled Trial for Liver Cancer Screening Feasible or Still Needed?

Hossein Poustchi et al.

HEPATOLOGY (2011)

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Article Gastroenterology & Hepatology

Noninvasive diagnostic criteria for hepatocellular carcinoma in hepatic masses > 2 cm in a hepatitis B virus-endemic area

Sung Eun Kim et al.

LIVER INTERNATIONAL (2011)

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Article Gastroenterology & Hepatology

Is Tumor Biopsy Necessary?

Beat Muellhaupt et al.

LIVER TRANSPLANTATION (2011)

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Article Cardiac & Cardiovascular Systems

Prospective Randomized Study of Doxorubicin-Eluting-Bead Embolization in the Treatment of Hepatocellular Carcinoma: Results of the PRECISION V Study

Johannes Lammer et al.

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2010)

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Article Gastroenterology & Hepatology

Semiannual surveillance is superior to annual surveillance for the detection of early hepatocellular carcinoma and patient survival

Valentina Santi et al.

JOURNAL OF HEPATOLOGY (2010)

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Article Gastroenterology & Hepatology

Hepatocellular Carcinoma: Ablate and Wait Versus Rapid Transplantation

John P. Roberts et al.

LIVER TRANSPLANTATION (2010)

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Review Gastroenterology & Hepatology

Pathology of Early Hepatocellular Carcinoma: Conventional and Molecular Diagnosis

Tania Roskams et al.

SEMINARS IN LIVER DISEASE (2010)

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Review Gastroenterology & Hepatology

Modified RECIST (mRECIST) Assessment for Hepatocellular Carcinoma

Riccardo Lencioni et al.

SEMINARS IN LIVER DISEASE (2010)

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Article Surgery

A Prospective, Randomized, Controlled Trial of Preoperative Transarterial Chemoembolization for Resectable Large Hepatocellular Carcinoma

Wei-Ping Zhou et al.

ANNALS OF SURGERY (2009)

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Article Oncology

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

E. A. Eisenhauer et al.

EUROPEAN JOURNAL OF CANCER (2009)

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Article Gastroenterology & Hepatology

α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma

Jorge A. Marrero et al.

GASTROENTEROLOGY (2009)

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Article Gastroenterology & Hepatology

Pathologic Diagnosis of Early Hepatocellular Carcinoma: A Report of the International Consensus Group for Hepatocellular Neoplasia

Masamichi Kojiro et al.

HEPATOLOGY (2009)

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Article Gastroenterology & Hepatology

The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma

Luca Di Tommaso et al.

JOURNAL OF HEPATOLOGY (2009)

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Article Oncology

Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis

Vincenzo Mazzaferro et al.

LANCET ONCOLOGY (2009)

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Article Oncology

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

Ann-Lii Cheng et al.

LANCET ONCOLOGY (2009)

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Article Surgery

Liver Transplantation for Hepatocellular Carcinoma: Results of Down-Staging in Patients Initially Outside the Milan Selection Criteria

M. Ravaioli et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2008)

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Article Gastroenterology & Hepatology

Cost Effectiveness of Alternative Surveillance Strategies for Hepatocellular Carcinoma in Patients With Cirrhosis

Karin L. Andersson et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2008)

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Article Gastroenterology & Hepatology

Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis

M. A. Silva et al.

GUT (2008)

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Article Surgery

A novel prognostic nomogram is more accurate than conventional staging systems for predicting survival after resection of hepatocellular carcinoma

Clifford S. Cho et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2008)

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Article Medicine, General & Internal

Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

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Article Surgery

Liver transplantation for hepatocellular carcinoma: Validation of the UCSF-Expanded criteria based on preoperative imaging

F. Y. Yao et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2007)

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Article Gastroenterology & Hepatology

Surveillance for early diagnosis of hepatocellular carcinoma:: Is it effective in intermediate/advanced cirrhosis?

Franco Trevisani et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2007)

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Article Surgery

Hepatocellular carcinoma recurrence and death following living and deceased donor liver transplantation

R. A. Fisher et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2007)

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Article Gastroenterology & Hepatology

The utility of Lens culinaris agglutinin-reactive α-fetoprotein in the diagnosis of hepatocellular carcinoma:: Evaluation in a United States referral population

Apinya Leerapun et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2007)

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Article Surgery

Living donor versus deceased donor liver transplantation for early irresectable hepatocellular carcinoma

C. M. Lo et al.

BRITISH JOURNAL OF SURGERY (2007)

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A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma

MS Chen et al.

ANNALS OF SURGERY (2006)

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Article Gastroenterology & Hepatology

Randomised controlled trial comparing percutaneous radiofrequency thermal ablation, percutaneous ethanol injection, and percutaneous acetic acid injection to treat hepatocellular carcinoma of 3 cm or less

SM Lin et al.

GUT (2005)

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Article Gastroenterology & Hepatology

Characterization of small nodules in cirrhosis by assessment of vascularity: The problem of hypovascular hepatocellular carcinoma

L Bolondi et al.

HEPATOLOGY (2005)

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Article Gastroenterology & Hepatology

A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma

S Shiina et al.

GASTROENTEROLOGY (2005)

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Hepatectomy for hepatocellular carcinoma with major portal or hepatic vein invasion: Results of a multicenter study

TM Pawlik et al.

SURGERY (2005)

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Article Radiology, Nuclear Medicine & Medical Imaging

Radiofrequency ablation of hepatocellular carcinoma: Treatment success as defined by histologic examination of the explanted liver

DSK Lu et al.

RADIOLOGY (2005)

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Article Oncology

Randomized controlled trial of screening for hepatocellular carcinoma

BH Zhang et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2004)

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Radiofrequency ablation of small hepatocellular carcinoma in cirrhotic patients awaiting liver transplantation -: A prospective study

V Mazzaferro et al.

ANNALS OF SURGERY (2004)

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Resection prior to liver transplantation for hepatocellular carcinoma

J Beighiti et al.

ANNALS OF SURGERY (2003)

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Article Radiology, Nuclear Medicine & Medical Imaging

Small hepatocellular carcinoma in cirrhosis: Randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection

RA Lencioni et al.

RADIOLOGY (2003)

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Review Gastroenterology & Hepatology

Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival

JM Llovet et al.

HEPATOLOGY (2003)

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Article Medicine, General & Internal

Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma:: a randomised controlled trial

JM Llovet et al.

LANCET (2002)

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Article Gastroenterology & Hepatology

Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma

CM Lo et al.

HEPATOLOGY (2002)

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