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Prolactin in headache and migraine: A systematic review of preclinical studies

HEADACHE (2023)

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Article Clinical Neurology

Prolactin signaling modulates stress-induced behavioral responses in a preclinical mouse model of migraine

Bianca N. Mason et al.

Summary: The study aimed to determine if prolactin signaling modulates stress-induced behavioral responses in a preclinical migraine model. It was found that prolactin plays a female-specific role in stress-induced behavioral responses through activation of Prlr on sensory neurons in the preclinical migraine model. This suggests a potential therapeutic strategy in modulating prolactin signaling in some cases of migraine.

HEADACHE (2022)

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Article Clinical Neurology

A prolactin-dependent sexually dimorphic mechanism of migraine chronification

Daigo Ikegami et al.

Summary: The study revealed a sexually dimorphic mechanism of migraine progression involving down-regulation of PRLR-L and increased signaling of circulating prolactin at PRLR-S. These findings suggest potential for novel sex-specific therapies, such as gene editing through nasal delivery of CRISPR/Cas9 constructs, to target migraine pain specifically in females.

CEPHALALGIA (2022)

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Article Clinical Neurology

Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine

Moe Watanabe et al.

Summary: This study reveals the mechanism of stress-induced migraine by activating KOR in the hypothalamus, increasing circulating prolactin, and sensitizing prolactin receptors in the trigeminal nerve. This sexually dimorphic mechanism helps explain the higher prevalence of migraine in females.

BRAIN (2022)

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Article Clinical Neurology

Meningeal CGRP-Prolactin Interaction Evokes Female-Specific Migraine Behavior

Amanda Avona et al.

Summary: This study found an interaction between prolactin and CGRP in the meninges of rodents, leading to female-specific migraine behaviors, potentially explaining the higher prevalence of migraines in women.

ANNALS OF NEUROLOGY (2021)

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Article Clinical Neurology

Opening of ATP sensitive potassium channels causes migraine attacks with aura

Mohammad Al-Mahdi Al-Karagholi et al.

Summary: This study found that the ATP-sensitive potassium channel opener levcromakalim may be a novel substance that induces migraine aura in humans. These findings highlight the ATP-sensitive potassium channel as a shared target in migraine aura and migraine headache. Opening of the ATP-sensitive potassium channel likely leads to triggering of aura and headache via distinct mechanisms.

BRAIN (2021)

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Review Medicine, General & Internal

Migraine: epidemiology and systems of care

Messoud Ashina et al.

Summary: Migraine is a global neurovascular disorder that has negative impacts on patients, families, and society. Integrated and coordinated care systems can help reduce this burden. Low and middle-income countries face challenges in migraine care due to inadequate public health education and access to medication.

LANCET (2021)

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Article Anesthesiology

Opening of BKCa channels causes migraine attacks: a new downstream target for the treatment of migraine

Mohammad Al-Mahdi Al-Karagholi et al.

Summary: This study found that BKCa channel opening may trigger migraine attacks, and BKCa channel blockers could be potential candidates for novel antimigraine drugs.

PAIN (2021)

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Targeting BKCa Channels in Migraine: Rationale and Perspectives

Mohammad Al-Mahdi Al-Karagholi et al.

CNS DRUGS (2020)

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The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females

Yanxia Chen et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Medicine, General & Internal

Migraine

Messoud Ashina

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Clinical Neurology

Opening of ATP-sensitive potassium channels causes migraine attacks: a new target for the treatment of migraine

Mohammad Al-Mahdi Al-Karagholi et al.

BRAIN (2019)

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Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent

Mayur Patil et al.

JOURNAL OF NEUROENDOCRINOLOGY (2019)

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Prolactin Regulates Pain Responses via a Female-Selective Nociceptor-Specific Mechanism

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ISCIENCE (2019)

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Review Clinical Neurology

The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

Mohammad Al-Mahdi Al-Karagholi et al.

JOURNAL OF HEADACHE AND PAIN (2017)

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Prolactin potentiates the activity of acid-sensing ion channels in female rat primary sensory neurons

Ting-Ting Liu et al.

NEUROPHARMACOLOGY (2016)

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Article Endocrinology & Metabolism

Prolactin regulates TRPV1, TRPA1, and TRPM8 in sensory neurons in a sex-dependent manner: Contribution of prolactin receptor to inflammatory pain

Mayur J. Patil et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)

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Article Biochemistry & Molecular Biology

Mechanisms of Transient Signaling via Short and Long Prolactin Receptor Isoforms in Female and Male Sensory Neurons

Sergei Belugin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Cell Biology

Prolonged stimulation with thyrotropin-releasing hormone and pituitary adenylate cyclase-activating polypeptide desensitize their receptor functions in prolactin-producing GH3 cells

Tselmeg Mijiddorj et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2013)

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SEX-DEPENDENT ROLES OF PROLACTIN AND PROLACTIN RECEPTOR IN POSTOPERATIVE PAIN AND HYPERALGESIA IN MICE

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Prolactin Regulates Tuberoinfundibular Dopamine Neuron Discharge Pattern: Novel Feedback Control Mechanisms in the Lactotrophic Axis

David J. Lyons et al.

JOURNAL OF NEUROSCIENCE (2012)

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Article Cell Biology

Stimulatory effect of pituitary adenylate-cyclase activating polypeptide (PACAP) and its PACAP type I receptor (PAC1R) on prolactin synthesis in rat pituitary somatolactotroph GH3 cells

Tselmeg Mijiddorj et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

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Article Clinical Neurology

The PACAP Receptor: A Novel Target for Migraine Treatment

Henrik W. Schytz et al.

NEUROTHERAPEUTICS (2010)

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Review Medicine, General & Internal

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

Alessandro Liberati et al.

PLOS MEDICINE (2009)

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Article Neurosciences

Prolactin modulates TRPV1 in female rat trigeminal sensory neurons

Anibal Diogenes et al.

JOURNAL OF NEUROSCIENCE (2006)

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Article Medicine, General & Internal

Serum prolactin and migraine

SA Masoud et al.

ANNALS OF SAUDI MEDICINE (2005)

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Article Physiology

PGE2 action in human coronary artery smooth muscle:: Role of potassium channels and signaling cross-talk

S Zhu et al.

JOURNAL OF VASCULAR RESEARCH (2002)

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