期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 45, 期 5, 页码 1281-1287出版社
WILEY
DOI: 10.1002/hed.27344
关键词
CD8; cetuximab; HPV; oropharynx; TILs
This study characterized the early changes in CD8(+) tumor-infiltrating lymphocytes and tumor transcriptomes after induction cetuximab. It was found that cetuximab can stimulate immune cell and cellular signaling changes within a short period of time.
BackgroundWe sought to characterize early changes in CD8(+) tumor-infiltrating lymphocytes and tumor transcriptomes after induction cetuximab in a cohort with p16-positive oropharyngeal cancer on a phase II clinical de-escalation trial. MethodsTumor biopsies were obtained before and 1 week after a single cetuximab loading dose in eight patients enrolled in a phase II trial of cetuximab and radiotherapy. Changes in CD8(+) tumor-infiltrating lymphocytes and transcriptomes were assessed. ResultsOne week after cetuximab, five patients (62.5%) had an increase in CD8(+) cell infiltration with a median (range) fold change of +5.8 (2.5-15.8). Three (37.5%) had unchanged CD8(+) cells (median [range] fold change of -0.85 [0.8-1.1]). In two patients with evaluable RNA, cetuximab induced rapid tumor transcriptome changes in cellular type 1 interferon signaling and keratinization pathways. ConclusionsWithin 1 week, cetuximab induced measurable changes in pro-cytotoxic T-cell signaling and immune content.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据