4.6 Article

Effect of bevacizumab in advanced low grade serous ovarian cancer: Data from the MITO 22 trial

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GYNECOLOGIC ONCOLOGY
卷 172, 期 -, 页码 72-77

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ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygyno.2023.03.011

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The study aimed to explore the efficacy of Bevacizumab (Bev) in the treatment of advanced low grade serous ovarian cancer (LGSOC) in both first-line and recurrent settings. The results showed that Bev combined with chemotherapy significantly improved progression-free survival (PFS) in LGSOC patients compared to chemotherapy alone, both in first-line and recurrent treatments. These findings suggest that Bev may be an effective treatment option for LGSOC.
Objective. The aim of the present analysis was to explore the efficacy of Bevacizumab (Bev) on survival out-come in advanced low grade serous ovarian cancer (LGSOC) both in first line and in recurrent setting.Methods. In retrospective observational multicenter study, we described the outcome of LGSOC patients en-rolled in the MITO 22 study and treated with chemotherapy (CT) with or without Bev. Patients receiving Bev in first-line or in recurrence were considered and compared with patients receiving CT alone (stage III and IV in first line; platinum based-CT in second line). Descriptive and survival analyses were performed for each group.Results. Out of 128 patients included in MITO 22, 46 LGSOC patients receiving Bev in first line setting or at the time of first recurrence were identified. In first line, 30 patients received Bev + CT and 65 CT alone and the median PFS were 47.86 months (95% CI: 31.48 -NR) and 22.63 months (95% CI 15-39.24) (p-value 0.0392), respectively. In the recurrent setting, 16 patients who received Bev + CT were compared to 33 women treated with platinum -based CT alone. Median PFS were 37.1 months (95% CI: 13.42-40.56) and 11.22 months (95% CI: 8.26-15.63) (p -value 0.013), respectively.Conclusions. Our study suggests that Bev might be effective in LGSOC both at diagnosis and at the time of relapse. These data warrants further studies.(c) 2023 Published by Elsevier Inc.

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