Significant underestimation of preventive effects in colorectal cancer screening trial

Article Gastroenterology & Hepatology

Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN

Eileen Morgan et al.

Summary: Colorectal cancer is the third most common cancer worldwide, with the highest incidence rates in Australia/New Zealand and Europe, and the lowest rates in Africa and Southern Asia. The burden of colorectal cancer is projected to increase by 2040, with the majority of cases predicted to occur in high HDI countries.

GUT (2023)

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Article Medicine, General & Internal

Long-Term Follow-up of the Italian Flexible Sigmoidoscopy Screening Trial

Carlo Senore et al.

Summary: The study demonstrates that a single FS screening has a long-term protective effect on both CRC incidence and mortality, lasting up to 15 and 19 years. There was a significant reduction in colorectal cancer mortality among men, while no significant effect was observed among women.

ANNALS OF INTERNAL MEDICINE (2022)

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Article Medicine, General & Internal

15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality A Pooled Analysis of Randomized Trials

Frederik E. Juul et al.

Summary: Pooled analysis of four large-scale randomized trials of sigmoidoscopy screening demonstrates a significant and sustained effect of sigmoidoscopy on reducing the incidence and mortality of colorectal cancer for 15 years.

ANNALS OF INTERNAL MEDICINE (2022)

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Article Medicine, General & Internal

Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death

M. Bretthauer et al.

Summary: This randomized trial found that participants who were invited to undergo screening colonoscopy had a lower risk of colorectal cancer within 10 years.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Oncology

Effects of screening for colorectal cancer: Development, documentation and validation of a multistate Markov model

Thomas Heisser et al.

Summary: Simulation models, such as the COSIMO model, are powerful tools for evaluating the effectiveness of colorectal cancer screening strategies. This specific model accurately predicted colorectal neoplasm prevalence and incidence in a German population for up to 25 years, showing potential for assessing comparative effectiveness of screening strategies.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Review Medicine, General & Internal

Colorectal Cancer Screening: An Updated Modeling Study for the US Preventive Services Task Force

Amy B. Knudsen et al.

Summary: This study provides updated model-based estimates of colorectal cancer screening strategies for individuals at average risk, aiming to identify efficient strategies that balance life-years gained and colonoscopy burden.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Gastroenterology & Hepatology