Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn's disease highlight earliest events of pathogenesis

Article Gastroenterology & Hepatology

A Role for CXCR3 Ligands as Biomarkers of Post-Operative Crohn's Disease Recurrence

Margaret Walshe et al.

Summary: Blood-based biomarkers, particularly CXCR3 ligands, are associated with Crohn's disease recurrence following ileocolic resection. These markers improve the ability to identify CD recurrence.

JOURNAL OF CROHNS & COLITIS (2022)

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Article Gastroenterology & Hepatology

The Effect of Phenotype and Genotype on the Plasma Proteome in Patients with Inflammatory Bowel Disease

Arno R. Bourgonje et al.

Summary: This study reveals a strong association between genotype and multiple disease phenotypes with the plasma inflammatory proteome in patients with IBD, identifying disease-associated pathways that may help improve disease management in the future.

JOURNAL OF CROHNS & COLITIS (2022)

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Review Biochemistry & Molecular Biology

Antibody signatures in inflammatory bowel disease: current developments and future applications

Arno R. Bourgonje et al.

Summary: The adequate functioning of the intestinal barrier is crucial for protecting against pathogens and tolerating microbiota and self-antigens. Inflammatory bowel diseases (IBDs) are characterized by a disrupted intestinal barrier integrity, resulting in an abnormal immune response. Recent innovative antibody profiling technologies have the potential to provide a comprehensive understanding of humoral immunity and its applications in disease diagnosis, therapy, and prevention in IBD.

TRENDS IN MOLECULAR MEDICINE (2022)

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Article Gastroenterology & Hepatology

Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis

Heather J. Galipeau et al.

Summary: Increased fecal proteolytic activity was found before the clinical diagnosis of UC, which may serve as a noninvasive biomarker of inflammation associated with changes in gut microbiota. The study suggests potential therapeutic targets for at-risk populations based on antiprotease treatments.

GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease

R. Kalla et al.

Summary: Personalized medicine success in complex diseases relies on biomarker discovery. A study identified serum proteins distinguishing IBD from non-IBD, as well as predicting escalation with specific protein combinations. The research also highlighted proteins associated with genetic variations, urging further validation in prospective studies.

JOURNAL OF CROHNS & COLITIS (2021)

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Review Biochemistry & Molecular Biology

On the Road to Accurate Protein Biomarkers in Prostate Cancer Diagnosis and Prognosis: Current Status and Future Advances

Yiwu Yan et al.

Summary: Prostate cancer is a leading cause of morbidity and mortality among men worldwide, and advancements in multiple protein biomarkers offer hope for its diagnosis and prognosis. The identification of multi-protein biomarkers with high sensitivity and specificity, as well as their integration with clinicopathologic parameters, imaging, and other molecular biomarkers, can help achieve optimal personalized management for PC patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Gastroenterology & Hepatology

Oncostatin M Is a Biomarker of Diagnosis, Worse Disease Prognosis, and Therapeutic Nonresponse in Inflammatory Bowel Disease

Sare Verstockt et al.

Summary: The study found that Oncostatin M (OSM) can serve as a diagnostic biomarker in the tissue and serum of IBD patients, as well as predict prognosis and response to biologic therapies. Elevated ileal OSM/OSMR levels were significantly associated with postoperative recurrent CD. Serum OSM levels were increased in newly diagnosed patients and postoperative patients with recurrent CD. In families with IBD, higher serum levels were observed in first-degree relatives (FDRs) than in control families.

INFLAMMATORY BOWEL DISEASES (2021)

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Article Gastroenterology & Hepatology

TREM-1+ Macrophages Define a Pathogenic Cell Subset in the Intestine of Crohn's Disease Patients

Charles Caer et al.

Summary: The study showed that high expression of intestinal TREM-1 in IBD patients is associated with a high frequency of TREM-1(+) immature macrophages and TREM-1(+)CD11b(+) granulocytes, which contribute to the deleterious inflammatory microenvironment. Blocking the TREM-1 pathway, especially simultaneously with anti-TNF therapy, has potential as a new therapy for IBD.

JOURNAL OF CROHNS & COLITIS (2021)

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Article Gastroenterology & Hepatology

Development and Validation of Test for Leaky Gut Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults

Katayoun Khoshbin et al.

Summary: This study aimed to obtain normative data on small intestinal and colonic permeability. Results showed that C-13-mannitol is the preferred probe for small intestinal permeability, while C-12-mannitol is not suitable for use.

GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration Across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis

Meghali Nighot et al.

Summary: This study demonstrates the important role of MMP-12 in intestinal TJ barrier function and inflammation, showing that MMP-12(-/-) mice have increased tolerance to DSS colitis. Macrophage transmigration across the epithelial layer is MMP-12 dependent, highlighting MMP-12-mediated degradation of basement membrane laminin as a key pathogenic factor for intestinal inflammation.

JOURNAL OF CROHNS & COLITIS (2021)

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Article Multidisciplinary Sciences

Serum biomarkers confirming stable remission in inflammatory bowel disease

Christoph Kessel et al.

Summary: Crohn's disease (CD) and ulcerative colitis (UC) have a chronic-remittent course. Optimal management of inflammatory bowel diseases (IBD) relies on early intervention, treat-to-target strategies and a tight disease control. However, it is challenging to assess the risk of relapses in individual patients. We investigated blood-based biomarkers for the confirmation of disease remission in patients with IBD. Our study identified serum biomarkers with the potential to indicate unstable disease control in IBD, which may help to steer individual therapies to maintain remission.

SCIENTIFIC REPORTS (2021)

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Review Medicine, General & Internal

The Charming World of the Extracellular Matrix: A Dynamic and Protective Network of the Intestinal Wall

Simona Pompili et al.

Summary: The intestinal extracellular matrix (ECM) is a complex network of proteins that plays a crucial role in maintaining tissue structure and function. Interaction between ECM and cells is essential for cell development, proliferation, and apoptosis.

FRONTIERS IN MEDICINE (2021)

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Article Gastroenterology & Hepatology

Anti-Microbial Antibody Response is Associated With Future Onset of Crohn's Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk

Sun-Ho Lee et al.

Summary: High baseline total positive antibody response is associated with an increased risk of developing CD in the future, independently of abnormal gut barrier function, subclinical inflammation, and CD-related genetic risks. Causal mediation analysis showed that the effect of high AS on future CD development is partially mediated through preclinical gut inflammation.

GASTROENTEROLOGY (2021)

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Article Gastroenterology & Hepatology

Systemic Inflammation in Preclinical Ulcerative Colitis

Daniel Bergemalm et al.

Summary: In preclinical ulcerative colitis, several inflammatory proteins are up-regulated years before diagnosis, which can effectively predict the risk of developing ulcerative colitis. These proteins are highly indicative of an ulcerative colitis diagnosis and show early upregulation upon exposure to genetic and environmental risk factors.

GASTROENTEROLOGY (2021)

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Review Immunology

Regulation of inflammation by the antioxidant haem oxygenase 1

Nicole K. Campbell et al.

Summary: HO-1, known for its antioxidant properties, has also been shown to have anti-inflammatory effects, making it a potential treatment for chronic inflammatory and autoimmune diseases. Inducing HO-1 has therapeutic potential, but there are challenges to translating this treatment to clinical use.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Gastroenterology & Hepatology

Serum Biomarkers Identify Patients Who Will Develop Inflammatory Bowel Diseases Up to 5 Years Before Diagnosis

Joana Torres et al.

GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

Increased Intestinal Permeability Is Associated With Later Development of Crohn 's Disease

Williams Turpin et al.

GASTROENTEROLOGY (2020)

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Letter Gastroenterology & Hepatology

TREM-1, the ideal predictive biomarker for endoscopic healing in anti-TNF-treated Crohn's disease patients?

Bram Verstockt et al.

GUT (2019)

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Article Gastroenterology & Hepatology

Su1928 – Tofacitinib Improves Clinical Disease Activity in a Real-World Population of Patients with Moderate-Severe Ulcerative Colitis and Crohn’s Disease

Kindra D. Clark-Snustad et al.

GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

Analysis of Genetic Association of Intestinal Permeability in Healthy First-degree Relatives of Patients with Crohn's Disease

Williams Turpin et al.

INFLAMMATORY BOWEL DISEASES (2019)

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Review Gastroenterology & Hepatology

Expert opinion for use of faecal calprotectin in diagnosis and monitoring of inflammatory bowel disease in daily clinical practice

Catherine Reenaers et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2018)

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Review Immunology

Heme Oxygenase-1 as a Modulator of Intestinal Inflammation Development and Progression

Valentina P. Sebastian et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease

Nathaniel R. West et al.

NATURE MEDICINE (2017)

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Article Multidisciplinary Sciences

Subphenotypes of inflammatory bowel disease are characterized by specific serum protein profiles

Erik Andersson et al.

PLOS ONE (2017)

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Article Gastroenterology & Hepatology

Serologic microbial associated markers can predict Crohn's disease behaviour years before disease diagnosis

R. S. Choung et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2016)

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Article Cell Biology

Heme oxygenase 1 controls early innate immune response of macrophages to Salmonella Typhimurium infection

Anna-Maria Mitterstiller et al.

CELLULAR MICROBIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Chemokine and cytokine levels in inflammatory bowel disease patients

Udai P. Singh et al.

CYTOKINE (2016)

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Review Gastroenterology & Hepatology

Preclinical and Undiagnosed Crohn's Disease: The Submerged Iceberg

Dario Sorrentino

INFLAMMATORY BOWEL DISEASES (2016)

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Article Genetics & Heredity

Association of host genome with intestinal microbial composition in a large healthy cohort

Williams Turpin et al.

NATURE GENETICS (2016)

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Article Gastroenterology & Hepatology

Determinants of Intestinal Permeability in Healthy First-Degree Relatives of Individuals with Crohn's Disease

David Kevans et al.

INFLAMMATORY BOWEL DISEASES (2015)

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Article Gastroenterology & Hepatology

A novel gas chromatography mass spectrometry-based serum diagnostic and assessment approach to ulcerative colitis

Michitaka Kohashi et al.

JOURNAL OF CROHNS & COLITIS (2014)

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Article Genetics & Heredity

Complex host genetics influence the microbiome in inflammatory bowel disease

Dan Knights et al.

GENOME MEDICINE (2014)

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Article Immunology

C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection

Le-Le Zhu et al.

IMMUNITY (2013)

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Article Immunology

C-type Lectin MCL Is an FcRγ-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord Factor

Yasunobu Miyake et al.

IMMUNITY (2013)

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Article Biochemistry & Molecular Biology

Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems

Des Raj Kashyap et al.

NATURE MEDICINE (2011)

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Article Biochemistry & Molecular Biology

Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood

Martin Lundberg et al.

NUCLEIC ACIDS RESEARCH (2011)

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Article Pharmacology & Pharmacy

Review article: Intestinal permeability in Crohn's disease

J. B. MEDDINGS

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2010)

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Review Gastroenterology & Hepatology

Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease

Noah P. Zimmerman et al.

INFLAMMATORY BOWEL DISEASES (2008)

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Article Gastroenterology & Hepatology

Diagnostic precision of fecal calprotectin for inflammatory bowel disease and colorectal malignancy

Alexander C. von Roon et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2007)

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Review Biochemistry & Molecular Biology

Matrix metalloproteinases (MMPs): Chemical-biological functions and (Q)SARs

Rajeshwar P. Verma et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

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Article Gastroenterology & Hepatology

Association of deficiency for mannan-binding lectin with anti-mannan antibodies in Crohn's disease: A family study

Frank Seibold et al.

INFLAMMATORY BOWEL DISEASES (2007)

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Article Gastroenterology & Hepatology

Immune sensitization to yeast antigens in ASCA-positive patients with Crohn's disease

A Konrad et al.

INFLAMMATORY BOWEL DISEASES (2004)

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Article Gastroenterology & Hepatology

Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario

JK Marshall et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2004)

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Article Medicine, Research & Experimental

Bacterial flagellin is a dominant antigen in Crohn disease

MJ Lodes et al.

JOURNAL OF CLINICAL INVESTIGATION (2004)

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Article Biochemistry & Molecular Biology

Peptidoglycan recognition proteins - A novel family of four human innate immunity pattern recognition molecules

C Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn's disease highlight earliest events of pathogenesis

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