Microglia play beneficial roles in multiple experimental seizure models

Seizure disorders are common, affecting both the young and the old. Currently available antiseizure drugs are ineffective in a third of patients and have been developed with a focus on known neurocentric mechanisms, raising the need for investigations into alternative and complementary mechanisms that contribute to seizure generation or its containment. Neuroinflammation, broadly defined as the activation of immune cells and molecules in the central nervous system (CNS), has been proposed to facilitate seizure generation, although the specific cells involved in these processes remain inadequately understood. The role of microglia, the primary inflammation-competent cells of the brain, is debated since previous studies were conducted using approaches that were less specific to microglia or had inherent confounds. Using a selective approach to target microglia without such side effects, we show a broadly beneficial role for microglia in limiting chemoconvulsive, electrical, and hyperthermic seizures and argue for a further understanding of microglial contributions to contain seizures.

Automated summary

Seizure disorders are common and current antiseizure drugs are ineffective for a third of patients. Neuroinflammation, the activation of immune cells and molecules in the central nervous system, is proposed to facilitate seizure generation. The role of microglia in this process is debated, but using a selective approach, it has been shown that microglia have a beneficial role in limiting seizures and further understanding is needed.